Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Karen A. Fortner"'
Autor:
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes c
Externí odkaz:
https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
Autor:
Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta, Teresa C. Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C. Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective an
Externí odkaz:
https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
An effective adaptive immune response requires rapid T cell proliferation, followed by equally robust cell death. These two processes are coordinately regulated to allow sufficient magnitude of response followed by its rapid resolution, while also pr
Externí odkaz:
https://doaj.org/article/53b3e9e2f92e4f2fa428c8859288ca61
Autor:
Christopher D. Scharer, Scott Legunn, Ramiro Barrantes-Reynolds, Karen A. Fortner, Ralph C. Budd
Publikováno v:
Antioxid Redox Signal
SIGNIFICANCE: Numerous abnormalities in T cells have been described in patients with systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation, expression of endogenous retroviruses (ERVs), increased cell death, enlarged mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76dc22ca7bc4f26da09e3deab5aeda0
https://europepmc.org/articles/PMC8982120/
https://europepmc.org/articles/PMC8982120/
Autor:
Karen A. Fortner, Christopher D. Scharer, Julie A. Dragon, Ralph C. Budd, Scott Tighe, Jeremy M. Boss
Publikováno v:
ImmunoHorizons
Systemic lupus erythematosus (SLE) is characterized by increased DNA demethylation in T cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The process driving the DNA demethylation and the consequences on overall
Autor:
Rui Yang, David E. Levy, Felipe Valença-Pereira, Emily Giddings, Alejandro V. Villarino, Isabelle Marie, Yina H. Huang, Haitao Wen, Mercedes Rincon, David A. Frank, Karen A. Fortner, Qian Fang
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence
Autor:
Felipe, Valença-Pereira, Qian, Fang, Isabelle J, Marié, Emily L, Giddings, Karen A, Fortner, Rui, Yang, Alejandro V, Villarino, Yina H, Huang, David A, Frank, Haitao, Wen, David E, Levy, Mercedes, Rincon
Publikováno v:
Proc Natl Acad Sci U S A
Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence
Autor:
Devin P. Champagne, Karatatiwant Singh Sidhu, Robert W. Robey, Angelo D'Alessandro, Janice Y. Bunn, Susan E. Bates, Brian Silverstrim, Tina M. Thornton, Steven Fiering, Joshua M. Laffin, Karen A. Fortner, Dwight E. Matthews, Hugo Arias-Pulido, Felipe Valença-Pereira, Natalia Romero, Mercedes Rincon, Shana O. Kelley, Mark P. Pereira, Phoebe Cao, Domink Stich, Emily Giddings, Meng Han Wu, Yoonseok Kam, James East, Rachel Culp-Hill
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP binding cassette (ABC) transporters remains a significant problem. The development of safe and
Autor:
Zain Kassam, Mario Velez, Gary M. Mawe, Peter W. Callas, Wing Fei Wong, Ryan J. Elliott, Aaron H. Cohn, Peter L. Moses, Nathaniel D. Chu, Eric J. Alm, Ralph C. Budd, Elaine Vo, Karen A. Fortner, Le Thanh Tu Nguyen, Rebecca Wilcox, Roxana del Rio-Guerra, Jessica W. Crothers, Brigitte Lavoie, Cheryl Collins, Magen Phillips, Mark D. Smith
Publikováno v:
BMC Gastroenterology
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-16 (2021)
Background Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as a safety and feasibility study of long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5745725c752004be63176a5d63f1df46
https://doi.org/10.21203/rs.3.rs-62372/v1
https://doi.org/10.21203/rs.3.rs-62372/v1
Autor:
Javier Crespo, Virginia Gutiérrez-de Juan, Juan Anguita, Karen A. Fortner, Devin P. Champagne, Brock C. Christensen, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Dhaval Oza, María L. Martínez-Chantar, Youdinghuan Chen, Daniela Mestre, Qian Fang, Marta Varela-Rey, Paula Iruzubieta, Teresa C. Delgado, Lucía Barbier-Torres, Águeda González-Rodríguez, David Fernández-Ramos, Patricia Aspichueta, Beatriz Gomez-Santos, Carmelo García-Monzón, Felipe Valença-Pereira, Mercedes Rincon, Emily Giddings, Frederic Tremblay
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Universidad de Cantabria (UC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Universidad de Cantabria (UC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ (Methylation-Controlled J pr