Výsledky vyhledávání - "Karen A. Canella"

Identification of individual benzo[c]phenanthrenedihydrodiol epoxide-DNA adducts by the phosphorus-32-postlabeling assay

Autor: Kimmo Peltonen, Anthony Dipple, Haruhiko Yagi, Karen A. Canella, Donald M. Jerina

Publikováno v: Chemical Research in Toxicology. 5:685-690

Purine deoxyribonucleoside 3'-phosphates were reacted separately with the four configurational isomers of benzo[c]phenanthrene 3,4-dihydrodiol 1,2-epoxide. Products resulting from the cis and trans opening of the epoxide ring by the exocyclic amino g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea308e5feeea2f15a45e7829336b575e
https://doi.org/10.1021/tx00029a015

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DNA polymerase action on benzo[a]pyrene—DNA adducts

Autor: Andrew M. Hruszkewycz, Karen A. Canella, Anthony Dipple, Leena Kotrappa, Kimmo Peltonen

Publikováno v: Carcinogenesis. 13:2347-2352

A 16mer oligonucleotide containing a single guanine residue at nucleotide 13 from the 3' end was treated with the (+)-enantiomer of the 7,8-dihydrodiol 9,10-epoxide of benzo[a]pyrene (B[a]P). Oligonucleotides containing either an adduct in which the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf4e5ac01bf6bf0b777977cc4c9f963
https://doi.org/10.1093/carcin/13.12.2347

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Identification of (+) and (−) anti benzo[a]pyrene dihydrodiol epoxide–nucleic acid adducts by the 32P-postlabeling assay

Autor: Anthony Dipple, Kimmo Peltonen, Karen A. Canella

Publikováno v: Carcinogenesis. 12:1109-1114

Purine deoxyribonucleoside 3'-phosphates were reacted with the (+)- and (-)-enantiomers of the anti dihydrodiol epoxide of benzo[a]pyrene. Products from cis and trans opening of the epoxide ring were separated by HPLC and they were identified by comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2169f69d48ba0bc084f4d58e64848f
https://doi.org/10.1093/carcin/12.6.1109

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Synthesis and enantiomeric resolution of tritiated (D,L)-3-hydroxykynurenine

Autor: John R. Lever, Karen A. Canella, Clifford L. Eastman, Tomás R. Guilarte

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 28:1331-1339

The synthesis, purification and enantiomeric resolution of tritiated (D,L)-3-hydroxykynurenine are described. Bromination of racemic 3-hydroxykynurenine, catalytic dehalotritiation and purification by ion pair, reverse phase HPLC afforded tritiated m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70ee3a08bdb2bcc271a5ca0a547dcf12
https://doi.org/10.1002/jlcr.2580281113

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Mutation spectra in supF: approaches to elucidating sequence context effects

Autor: Michael M. Seidman, Karen A Canella

Publikováno v: Mutation research. 450(1-2)

Shuttle vectors carrying the supF suppressor tRNA gene were originally developed for mutagenesis experiments in primate and human cells. Since then, the supF gene has been used as a mutation reporter in other mammalian cells, yeast, Escherichia coli,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d32a8c52a7c3178f3152540253851f
https://pubmed.ncbi.nlm.nih.gov/10838134

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Benzo[c]phenanthrene-DNA adducts in mouse epidermis in relation to the tumorigenicities of four configurationally isomeric 3,4-dihydrodiol 1,2-epoxides

Autor: Donald M. Jerina, Haruhiko Yagi, Anthony Dipple, Rajiv Agarwal, Karen A. Canella

Publikováno v: Chemical research in toxicology. 9(3)

P-Postlabeling assays were used to monitor the binding to epidermal DNA that resulted from the application of each of the four configurational isomers of benzo[c]phenanthrene 3,4-dihydrodiol 1,2-epoxide to mouse skin in vivo. For three of these confi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d4efa90d62790bcdabb25d46b426db
https://pubmed.ncbi.nlm.nih.gov/8728502

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High-performance liquid chromatographic separation of purine deoxyribonucleoside monophosphate-benzo[a]pyrene adducts

Autor: Anthony Dipple, Karen A. Canella, Kimmo Peltonen

Publikováno v: Journal of chromatography. 623(2)

Chromatographic methods that allow the separation of adducts of purine nucleoside 3′-phosphates with the pure enantiomers of the anti -dihydrodiol epoxide of benzo[ a ]pyrene are developed. The optimization procedure includes evaluation of the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79af6b4f81734f0a7fa27549442616f2
https://pubmed.ncbi.nlm.nih.gov/1460077

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DNA polymerase-mediated nucleotide incorporation adjacent to hydrocarbon-deoxyadenosine and hydrocarbon-deoxyguanosine adducts

Autor: Karen A. Canella, Anthony Dipple, Andrew M. Hruszkewycz

Publikováno v: Carcinogenesis. 12(9)

To examine the effect of DNA adducts on nucleotide incorporation by DNA polymerase at 3' neighboring bases, synthetic oligonucleotides (16mers) containing a purine at position 13 from the 3' end and any one of the four possible bases at position 12 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ecdf1bc8766e70422fc4ae89a1413e
https://pubmed.ncbi.nlm.nih.gov/1893525

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