Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Karen A Ryall"'
Autor:
Manuel A Silva, Karen A Ryall, Claudia Wilm, Jenifer Caldara, Hans Juergen Grote, Janet C Patterson-Kane
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0196464 (2018)
Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death globally, and new immunotherapies developed and under development targeting PD-1/PD-L1 checkpoint inhibition require accurate patient selection to assure good clinical outcome. P
Externí odkaz:
https://doaj.org/article/0ab364424d8a443ab0080ee4078a44f9
Autor:
Scott A. Simpson, Christian R.R. Goans, Ryan M. Loh, Karen A. Ryall, Molly Middleton, Alicia Dalton
Publikováno v:
Journal of the Academy of Consultation-Liaison Psychiatry. 64:3-12
Suicidality alone is insensitive to suicide risk among emergency department (ED) patients.We describe the performance of adding an objective assessment of agitation to a suicide screening instrument for predicting suicide and self-harm after an ED en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1881a493b75cafb13f29fc59b626868
https://doi.org/10.1016/j.jaclp.2022.07.004
https://doi.org/10.1016/j.jaclp.2022.07.004
Autor:
Rhianna C. Laker, Joshua C. Drake, Rebecca J. Wilson, Vitor A. Lira, Bevan M. Lewellen, Karen A. Ryall, Carleigh C. Fisher, Mei Zhang, Jeffrey J. Saucerman, Laurie J. Goodyear, Mondira Kundu, Zhen Yan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 si
Externí odkaz:
https://doaj.org/article/45800b0013144c79a5f7f403114864d6
Autor:
John Schwarz, Gregory P. Dooley, Michael J. Kosnett, Ashley Brooks-Russell, Benjamin Steinhart, Kyle Friedman, Julia Wrobel, Gary Milavetz, Karen A. Ryall, Elise Amioka, George Sam Wang, Tim Brown
Publikováno v:
Accid Anal Prev
Objective Daily cannabis users develop tolerance to some drug effects, but the extent to which this diminishes driving impairment is uncertain. This study compared the impact of acute cannabis use on driving performance in occasional and daily cannab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d723f0c671f56e2d4d3f3be5821fb1
https://europepmc.org/articles/PMC8409327/
https://europepmc.org/articles/PMC8409327/
Autor:
Bevan M. Lewellen, Vitor A. Lira, Carleigh C. Fisher, Mei Zhang, Zhen Yan, Mondira Kundu, Rebecca J. Wilson, Karen A. Ryall, Joshua C. Drake, Jeffrey J. Saucerman, Rhianna C. Laker, Laurie J. Goodyear
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Mitochondrial health is critical for skeletal muscle function and is improved by exercise training through both mitochondrial biogenesis and removal of damaged/dysfunctional mitochondria via mitophagy. The mechanisms underlying exercise-induced mitop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dce53f2e5ea1834793f5383cec9b977
http://link.springer.com/article/10.1038/s41467-017-00520-9
http://link.springer.com/article/10.1038/s41467-017-00520-9
Autor:
Karen A. Ryall, Jihye Kim, Trista K. Hinz, Jaewoo Kang, Minjae Yoo, Aik Choon Tan, Lynn E. Heasley, Jimin Shin
Publikováno v:
Bioinformatics. 31:3799-3806
Motivation: Targeted kinase inhibitors have dramatically improved cancer treatment, but kinase dependency for an individual patient or cancer cell can be challenging to predict. Kinase dependency does not always correspond with gene expression and mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba4d9eeb6c12a42a540948c9122c9df
https://doi.org/10.1093/bioinformatics/btv427
https://doi.org/10.1093/bioinformatics/btv427
Autor:
Peng Xu, Zhen Yan, Mei Zhang, Deena Damschroder, Robert Wessells, Paul N. Adler, Karen A. Ryall, Jeffrey J. Saucerman
Publikováno v:
Journal of molecular and cellular cardiology. 127
In yeast, the Atg2-Atg18 complex regulates Atg9 recycling from phagophore assembly site during autophagy; their function in higher eukaryotes remains largely unknown. In a targeted screening in Drosophila melanogaster, we show that Mef2-GAL4-RNAi-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3627b9409c5e09e946c0250c6b938041
https://pubmed.ncbi.nlm.nih.gov/30571977
https://pubmed.ncbi.nlm.nih.gov/30571977
Publikováno v:
Pharmacogenomics. 17:95-97
Kinase dependency in cancer Recent large-scale cancer genome projects such as The Cancer Genome Atlas and the International Cancer Genome Consortium have systematically characterized genes and pathways that are implicated in tumor initiation and prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a5653cfa463da4731fc9396d66f296
https://doi.org/10.2217/pgs.15.154
https://doi.org/10.2217/pgs.15.154
Autor:
S. Gail Eckhardt, Aik Choon Tan, Carol A. Sartorius, Karen A. Ryall, Anna Capasso, John J. Tentler, Anastasia A. Ionkina, Peter Kabos, Todd M. Pitts, Rebekah R. Howison, Jihye Kim, Jennifer R. Diamond
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 7 (2017)
Frontiers in Oncology, Vol 7 (2017)
Purpose Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis and for which there are limited therapeutic options. The purpose of this study was to evaluate the efficacy of ENMD-2076 in p53-mutated TNBC patient-derived xeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7741203e509e6646ed40ca48ec1629e0
https://pubmed.ncbi.nlm.nih.gov/28555173
https://pubmed.ncbi.nlm.nih.gov/28555173
Autor:
Jocelyn P, Wong, Jason R, Todd, Martina A, Finetti, Frank, McCarthy, Malgorzata, Broncel, Simon, Vyse, Maciej T, Luczynski, Stephen, Crosier, Karen A, Ryall, Kate, Holmes, Leo S, Payne, Frances, Daley, Patty, Wai, Andrew, Jenks, Barbara, Tanos, Aik-Choon, Tan, Rachael C, Natrajan, Daniel, Williamson, Paul H, Huang
Publikováno v:
Cell Reports
Summary Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::085992e8cf35649295eb7fcd57bdab74
https://pubmed.ncbi.nlm.nih.gov/27783942
https://pubmed.ncbi.nlm.nih.gov/27783942