Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen A, Cadwallader"'
Publikováno v:
Trends in Immunology. 26:434-439
Myeloid cells are key effectors of the innate immune response, and as such are often required to migrate to, and function within, sites that are markedly hypoxic. To adapt to such oxygen deplete environments they have developed functional and surviva
Autor:
Edo Vellenga, Gwenny M. Fuhler, Karen A. Cadwallader, A. Lyndsay Drayer, Gerlinde J. Knol, Edwin R. Chilvers
Publikováno v:
Journal of Leukocyte Biology, 76(1), 254-262. FEDERATION AMER SOC EXP BIOL
The production of reactive oxygen species (ROS) by human neutrophils is imperative for their bactericidal activity. Proinflammatory agents such as granulocyte macrophage-colony stimulating factor (GM-CSF) can prime ROS production in response to chemo
Autor:
Nicholas T. Ktistakis, Edwin R. Chilvers, Alison M. Condliffe, Jeremy N. Skepper, Mohib Uddin, Jessica F. White, Karen A. Cadwallader, Andrew S. Cowburn
Publikováno v:
European Journal of Biochemistry. 271:2755-2764
Phospholipase D (PLD) plays a major role in the activation of the neutrophil respiratory burst. However, the repertoire of PLD isoforms present in these primary cells, the precise mechanism of activation, and the impact of cell priming on PLD activit
Publikováno v:
Blood. 100:2607-2616
Phosphoinositide 3-kinase (PI3-kinase)-dependent phosphorylation of the proapoptotic Bcl-2 family member Bad has been proposed as an important regulator of apoptotic cell death. To understand the importance of this pathway in nontransformed hematopoi
Autor:
Benjamin J. Reed, Diana Bilton, Karen A. Cadwallader, Edwin R. Chilvers, Ravi Mahadeva, Mary T. Keogan, David A. Lomas, Jasvir Parmar, Neda Farahi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 26:723-730
Plasma deficiency of alpha(1)-antitrypsin is most commonly due to the Z mutation ((342)Glu--> Lys) and is associated with early-onset panlobular emphysema. The lung disease in these patients is attributed to the relative deficiency of circulating alp
Autor:
Andrew S. Cowburn, Karen A. Cadwallader, Robert C. Rintoul, Edwin R. Chilvers, Trevor R. Walker, Alison M. Condliffe
Publikováno v:
Respiratory Research
Condliffe, A M, Cadwallader, K A, Walker, T R, Rintoul, R C, Cowburn, A S & Chilvers, E R 2000, ' Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells ', Respiratory research, vol. 1, no. 1, pp. 24 . https://doi.org/10.1186/rr8
Respiratory Research, Vol 1, Iss 1, Pp 24-29 (2000)
Condliffe, A M, Cadwallader, K A, Walker, T R, Rintoul, R C, Cowburn, A S & Chilvers, E R 2000, ' Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells ', Respiratory research, vol. 1, no. 1, pp. 24 . https://doi.org/10.1186/rr8
Respiratory Research, Vol 1, Iss 1, Pp 24-29 (2000)
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of cellular responses including survival, a
Autor:
Charlotte Summers, Jessica F. White, Iain MacKenzie, Edwin R. Chilvers, Andrew S. Cowburn, Raaj K. Praseedom, A. Mike Peters, Karen A. Cadwallader
Publikováno v:
Japanese Clinical Medicine, Vol 4 (2011)
Journal of Cell Death, Vol 2011, Iss 4, Pp 1-5 (2011)
Journal of Cell Death, Vol 2011, Iss 4, Pp 1-5 (2011)
In contrast to radiolabelled erythrocytes and platelets, radiolabelled neutrophils leave the circulating blood in an exponential manner, indicating random rather than age-dependent removal. Neutrophils transit the spleen with a range of residence tim
Autor:
Diana Bilton, M. C. Pasteur, Karen A. Cadwallader, Saad F Idris, H. Barker, Charles S. Haworth, D. J. McKeon, Edwin R. Chilvers, Alison M. Condliffe, Andrew S. Cowburn
Publikováno v:
The European respiratory journal. 35(6)
Previous studies have identified abnormalities in the oxidative responses of the neutrophil in cystic fibrosis (CF), but it is unclear whether such changes relate to loss of membrane cystic fibrosis transmembrane conductance regulator (CFTR) or to th
Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils
Autor:
Andrew S. Cowburn, Joanna Murray, John Bradley, Anastasia Sobolewski, Ben J. Reed, Edwin R. Chilvers, John Deighton, Karen A. Cadwallader
Publikováno v:
The Journal of biological chemistry. 281(18)
Neutrophil apoptosis plays a central role in the resolution of granulocytic inflammation. We have shown previously that tumor necrosis factor-alpha (TNFalpha) enhances the rate of neutrophil apoptosis at early time points via a mechanism involving bo
Autor:
Karen A, Cadwallader, Mohib, Uddin, Alison M, Condliffe, Andrew S, Cowburn, Jessica F, White, Jeremy N, Skepper, Nicholas T, Ktistakis, Edwin R, Chilvers
Publikováno v:
European journal of biochemistry. 271(13)
Phospholipase D (PLD) plays a major role in the activation of the neutrophil respiratory burst. However, the repertoire of PLD isoforms present in these primary cells, the precise mechanism of activation, and the impact of cell priming on PLD activit