Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Karen Sermon"'
Autor:
Nuša Krivec, Edouard Couvreu de Deckersberg, Yingnan Lei, Diana Al Delbany, Marius Regin, Stefaan Verhulst, Leo A. van Grunsven, Karen Sermon, Claudia Spits
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-14 (2024)
Abstract Gain of 1q is a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of the three germ layers, leading to mis-specification to crani
Externí odkaz:
https://doaj.org/article/60a272474826499d95706714b1b9604e
Autor:
Marius Regin, Yingnan Lei, Edouard Couvreu De Deckersberg, Charlotte Janssens, Anfien Huyghebaert, Yves Guns, Pieter Verdyck, Greta Verheyen, Hilde Van de Velde, Karen Sermon, Claudia Spits
Publikováno v:
eLife, Vol 12 (2024)
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies in mouse embryos and human gastruloi
Externí odkaz:
https://doaj.org/article/d12baf7b12df4606b80bb96d4ee9e701
Autor:
Joke Mertens, Florence Belva, Aafke P. A. van Montfoort, Marius Regin, Filippo Zambelli, Sara Seneca, Edouard Couvreu de Deckersberg, Maryse Bonduelle, Herman Tournaye, Katrien Stouffs, Kurt Barbé, Hubert J. M. Smeets, Hilde Van de Velde, Karen Sermon, Christophe Blockeel, Claudia Spits
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to birthweight di
Externí odkaz:
https://doaj.org/article/cb9554f3c7f040908d255c9128715707
Autor:
Diana Al Delbany, Manjusha S. Ghosh, Nuša Krivec, Anfien Huyghebaert, Marius Regin, Mai Chi Duong, Yingnan Lei, Karen Sermon, Catharina Olsen, Claudia Spits
Publikováno v:
Cells, Vol 13, Iss 16, p 1395 (2024)
Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study analyzed ten human embryonic stem c
Externí odkaz:
https://doaj.org/article/f33b5cac2e3f4190848f9fe68bce0e32
Autor:
Dominika Dziedzicka, Mukul Tewary, Alexander Keller, Laurentijn Tilleman, Laura Prochazka, Joel Östblom, Edouard Couvreu De Deckersberg, Christina Markouli, Silvie Franck, Filip Van Nieuwerburgh, Claudia Spits, Peter W. Zandstra, Karen Sermon, Mieke Geens
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as wel
Externí odkaz:
https://doaj.org/article/9e385811ab3744d7a6a8dfcfa4c06319
Autor:
Filippo Zambelli, Joke Mertens, Dominika Dziedzicka, Johan Sterckx, Christina Markouli, Alexander Keller, Philippe Tropel, Laura Jung, Stephane Viville, Hilde Van de Velde, Mieke Geens, Sara Seneca, Karen Sermon, Claudia Spits
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 102-114 (2018)
Summary: In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed in the cells used to establish the lines. Early-pa
Externí odkaz:
https://doaj.org/article/8defa2d8cf0e42db869aab5bc5235d69
Publikováno v:
Bio-Protocol, Vol 9, Iss 13 (2019)
Detecting heteroplasmies in the mitochondrial DNA (mtDNA) has been a challenge for many years. In the past, Sanger sequencing was the main option to perform this analysis, however, this method could not detect low frequency heteroplasmies. Massive Pa
Externí odkaz:
https://doaj.org/article/aff9c16b6cc04710a2c5d5ccc5304d22
Autor:
Kurt Jacobs, Filippo Zambelli, Afroditi Mertzanidou, Ilse Smolders, Mieke Geens, Ha Thi Nguyen, Lise Barbé, Karen Sermon, Claudia Spits
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 330-341 (2016)
Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked
Externí odkaz:
https://doaj.org/article/4222fde08724456886ef948b0fcfc442
Autor:
Joke Mertens, Marius Regin, Neelke De Munck, Edouard Couvreu de Deckersberg, Florence Belva, Karen Sermon, Herman Tournaye, Christophe Blockeel, Hilde Van de Velde, Claudia Spits
Publikováno v:
Human Molecular Genetics. 31:3629-3642
Humans present remarkable diversity in their mitochondrial DNA (mtDNA) in terms of variants across individuals as well as across tissues and even cells within one person. We have investigated the timing of the first appearance of this variant-driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d3fa027bdd6b40488ff22d3a612a2c
https://doi.org/10.1093/hmg/ddac059
https://doi.org/10.1093/hmg/ddac059
Autor:
Joke Mertens, Florence Belva, Aafke van Montfoort, Filippo Zambelli, Sara Seneca, Edouard Couvreu de Deckersberg, Maryse Bonduelle, Herman Tournaye, Katrien Stouffs, Kurt Barbé, Hubert Smeets, Hilde Van de Velde, Karen Sermon, Christophe Blockeel, Claudia Spits
Children born using assisted reproductive technologies (ART) have an increased risk of a lower birth weight, the cause of which remains unclear. As a causative factor, we hypothesized that variants in the mitochondrial DNA (mtDNA) that are not associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e01419a27eeaaf11f58c030d58c66925
https://doi.org/10.21203/rs.3.rs-2337956/v1
https://doi.org/10.21203/rs.3.rs-2337956/v1
