Výsledky vyhledávání - "Karen Rimmer"

Akademický článek

Home Mechanical Ventilation: A Canadian Thoracic Society Clinical Practice Guideline

Autor: Douglas A McKim, Jeremy Road, Monica Avendano, Steve Abdool, Fabien Côté, Nigel Duguid, Janet Fraser, François Maltais, Debra L Morrison, Colleen O’Connell, Basil J Petrof, Karen Rimmer, Robert Skomro, Canadian Thoracic Society Home Mechanical Ventilation Committee

Publikováno v: Canadian Respiratory Journal, Vol 18, Iss 4, Pp 197-215 (2011)

Increasing numbers of patients are surviving episodes of prolonged mechanical ventilation or benefitting from the recent availability of user-friendly noninvasive ventilators. Although many publications pertaining to specific aspects of home mechanic

Externí odkaz: https://doaj.org/article/60dcef673aca4844babb443293b5e0ca

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Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable 'Back-Up' Compound for N-tert-Butyl Isoquine

Publikováno v: Journal of Medicinal Chemistry. 52:1828-1844

On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydrox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2075934bbaca76abf6a07eb93897a
https://doi.org/10.1021/jm8012757

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Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

Autor: María Jesús, Gemma L. Ellis, Livia Vivas, Jill Davies, Emily Bongard, Alison E. Shone, Domingo Gargallo, Sarah C. Charnaud, Karen Rimmer, Richard Amewu, Paul M. O'Neill, Sunil Sabbani, Deborah Stanford, Peter Gibbons, Stephen A. Ward, Paul A. Stocks, Sonia Lozanom, Charlotte Hall

Publikováno v: Journal of Medicinal Chemistry. 51:2170-2177

A rapid, two-step synthesis of a range of dispiro-1,2,4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b9ed2f11ed04356cc9e1c48588770
https://doi.org/10.1021/jm701435h

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An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity

Autor: Paul M. O'Neill, Karen Rimmer, Steven A. Ward, Richard Amewu, Charlotte Hall, Gemma L. Ellis

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:1720-1724

Here we present an efficient route into synthetically challenging bridged 1,2,4,5-tetraoxanes. The key to the success of this route is the use of H2O2 and catalytic I-2 to form the gem-dihydroperoxide followed by a Ag2O mediated alkylation using 1,3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc187d458f862a1c30c6758b6439f522
https://doi.org/10.1016/j.bmcl.2008.01.053

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Is Your Patient Ready for Transport? Developing an ICU Patient Transport Decision Scorecard

Autor: Rosmin Esmail, Cheryl Cummings, Terrance Hulme, Judy Duffett-Martin, Teresa Thurber, Jonas Shultz, Karen Rimmer, Deborah Banack

Publikováno v: Healthcare Quarterly. 9:80-86

Transport of patients from the intensive care unit (ICU) to another area of the hospital can pose serious risks if the patient has not been assessed prior to transport. Recently, the Department of Critical Care Medicine, Calgary Health Region, experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fdeefa017334c64fcfa0cf72b97016
https://doi.org/10.12927/hcq.2013.18376

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Assessment and learning curve evaluation of endobronchial ultrasound skills following simulation and clinical training

Autor: David R, Stather, Paul, Maceachern, Karen, Rimmer, Christopher A, Hergott, Alain, Tremblay

Publikováno v: Respirology (Carlton, Vic.). 16(4)

Endobronchial ultrasound is a revolutionary diagnostic pulmonary procedure. The use of a computer endobronchial ultrasound simulator could improve trainee procedural skills before attempting to perform procedures on patients. This study aims to compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::042bb2949bdcbecf6bab7d6fce62f139
https://pubmed.ncbi.nlm.nih.gov/21355965

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