Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Karen, Vanhoorelbeke"'
Autor:
Nithya Prasannan, Bertina Dragunaite, Rens de Groot, Deepak Singh, Karen Vanhoorelbeke, Marie Scully
Publikováno v:
HemaSphere, Vol 7, p e3924819 (2023)
Externí odkaz:
https://doaj.org/article/58d1933445c74f06a4ccd5a7ac377d7f
Autor:
Edwige Tellier, Agnès Widemann, Raphaël Cauchois, Julien Faccini, Marie Lagarde, Marion Brun, Philippe Robert, Stéphane Robert, Richard Bachelier, Pascale Poullin, Elien Roose, Karen Vanhoorelbeke, Paul Coppo, Françoise Dignat-George, Gilles Kaplanski
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by a severe ADAMTS13 deficiency due to the presence of anti-ADAMTS13 auto-antibodies, with subsequent accumulation of circulating ultra-large von Willebrand factor (VWF) mult
Externí odkaz:
https://doaj.org/article/268edbcaee32430189336f9989489db4
Autor:
Mariangela J. Alfeo, Anna Pagotto, Giulia Barbieri, Timothy J. Foster, Karen Vanhoorelbeke, Vincenzo De Filippis, Pietro Speziale, Giampiero Pietrocola
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Staphylococcus aureus is the cause of a spectrum of diseases in humans and animals. The molecular basis of this pathogenicity lies in the expression of a variety of virulence factors, including proteins that mediate adherence to the host pla
Externí odkaz:
https://doaj.org/article/f7e8f93752b14d3a8ee37736626950c6
Autor:
Maya Imbrechts, Wim Maes, Louanne Ampofo, Nathalie Van den Berghe, Bas Calcoen, Dominique Van Looveren, Winnie Kerstens, Madina Rasulova, Thomas Vercruysse, Sam Noppen, Rana Abdelnabi, Caroline Foo, Kevin Hollevoet, Piet Maes, Xin Zhang, Dirk Jochmans, Karen Ven, Jeroen Lammertyn, Karen Vanhoorelbeke, Nico Callewaert, Paul De Munter, Dominique Schols, Hendrik Jan Thibaut, Johan Neyts, Paul Declerck, Nick Geukens
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104705- (2022)
Summary: Treatment with neutralizing monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to COVID-19 management. Unfortunately, SARS-CoV-2 variants escape several of these recently approved mA
Externí odkaz:
https://doaj.org/article/62ab4071a18b4ac48377864e5ae28caf
Autor:
Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Publikováno v:
Thrombosis Journal, Vol 19, Iss 1, Pp 1-7 (2021)
Abstract Background Mechanical removal of a thrombus by thrombectomy can be quite challenging. For reasons that are not fully understood, some thrombi require multiple passes to achieve successful recanalization, whereas other thrombi are efficiently
Externí odkaz:
https://doaj.org/article/022fd23ae42640719e4d28b7bbe959fb
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/b2974ca4f12940b7af1119cc52977053
Autor:
Kadri Kangro, Elien Roose, An‐Sofie Schelpe, Edwige Tellier, Gilles Kaplanski, Jan Voorberg, Simon F. De Meyer, Andres Männik, Karen Vanhoorelbeke
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 918-930 (2020)
Abstract Background In immune‐mediated thrombotic thrombocytopenic purpura (iTTP), patients develop an immune response against the multidomain enzyme ADAMTS13. ADAMTS13 consists of a metalloprotease (M) and disintegrin‐like (D) domain, 8 thrombos
Externí odkaz:
https://doaj.org/article/1b08d655e5664beab1e9d966ee70984e
Autor:
Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
The GPIbT-VWF A1 domain interaction is essential for platelet tethering under high shear. Synergy between GPIbα and GPVI signaling machineries has been suggested previously, however its molecular mechanism remains unclear. We generated a novel GPIb
Externí odkaz:
https://doaj.org/article/419fac8344784940b97373c9c7ae8edd
Autor:
Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The plasma metalloprotease ADAMTS13 regulates the platelet-tethering function of von Willebrand factor (VWF) in a shear-dependent manner. Here the authors present the ADAMTS13 crystal structure of the 70kDa N-terminal metalloprotease to spacer domain
Externí odkaz:
https://doaj.org/article/d27f55aa143e48378d1a3aee26caffd6
Autor:
Bas Calcoen, Nico Callewaert, Aline Vandenbulcke, Winnie Kerstens, Maya Imbrechts, Thomas Vercruysse, Kai Dallmeier, Johan Van Weyenbergh, Piet Maes, Xavier Bossuyt, Dorinja Zapf, Kersten Dieckmann, Kim Callebaut, Hendrik Jan Thibaut, Karen Vanhoorelbeke, Simon F. De Meyer, Wim Maes, Nick Geukens
Publikováno v:
Viruses, Vol 14, Iss 6, p 1257 (2022)
To mitigate the massive COVID-19 burden caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccination campaigns were initiated. We performed a single-center observational trial to monitor the mid- (3 months) and long-ter
Externí odkaz:
https://doaj.org/article/3f01fa74e2bc4897a3e3a5fcff302008