Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Karen, Seibert"'
Autor:
Amy Bellinghausen Stewart, Dana Villines, Tahira Yasmeen, Joel Saeedi, Michael D. Ries, Joumana Chaiban, Karen Seibert
Publikováno v:
Critical Care Medicine. 48:139-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567fe4063f3b5f0a8546ef8fbb7ace9f
https://doi.org/10.1097/01.ccm.0000619612.85254.ba
https://doi.org/10.1097/01.ccm.0000619612.85254.ba
Autor:
Karen Seibert, Christina M. Lockwood, Daniel Morgensztern, Kalin Guebert, Rakesh Nagarajan, Hussam Al-Kateb, Saiama N. Waqar, Catherine E. Cottrell, David H. Spencer, TuDung T. Nguyen, Maria Q. Baggstrom, John D. Pfeifer, Siddhartha Devarakonda, Ian S. Hagemann, Andrew J. Bredemeyer, Shashikant Kulkarni, Eric J. Duncavage, Ramaswamy Govindan
Publikováno v:
Cancer. 121:631-639
BACKGROUND A clinical assay was implemented to perform next-generation sequencing (NGS) of genes commonly mutated in multiple cancer types. This report describes the feasibility and diagnostic yield of this assay in 381 consecutive patients with non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0673d47ac8aa876846d26482e23a6b
https://doi.org/10.1002/cncr.29089
https://doi.org/10.1002/cncr.29089
Autor:
Justin T. Brown, Mark R. Johnson, Leslie D. McIntosh, Christina M. Lockwood, David H. Spencer, Stephanie M. O’Guin, Mark A. Watson, Catherine E. Cottrell, John D. Pfeifer, Christopher S. Sawyer, Jacqueline E. Payton, Jennifer L. Stratman, Jeffrey Milbrandt, Eric J. Duncavage, Herbert W. Virgin, Rakesh Nagarajan, Andrew J. Bredemeyer, Paul F. Cliften, Ian S. Hagemann, Bijoy George, Karen Seibert, Shashikant Kulkarni, TuDung T. Nguyen, Hussam Al-Kateb, Dayna M. Oschwald, Robi D. Mitra, Savita Shrivastava, Dorie A. Sher, Lauren C. Burcea, Seth D. Crosby, Richard D. Head, Haley J. Abel
Publikováno v:
The Journal of Molecular Diagnostics. 16:89-105
Currently, oncology testing includes molecular studies and cytogenetic analysis to detect genetic aberrations of clinical significance. Next-generation sequencing (NGS) allows rapid analysis of multiple genes for clinically actionable somatic variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fe3f5f6c32a4d707abcbb89e1ee648
https://doi.org/10.1016/j.jmoldx.2013.10.002
https://doi.org/10.1016/j.jmoldx.2013.10.002
Autor:
Louis C. Gerstenfeld, Deborah Phippard, Cindy Mielke, Thomas A. Einhorn, Karen Seibert, Dennis M. Cullinane, Mark Thiede, Bohus Svagr
Publikováno v:
Journal of Orthopaedic Research. 21:670-675
Non-steroidal anti-inflammatory drugs (NSAIDs) specifically inhibit cyclooxygenase (COX) activity and are widely used as anti-arthritics, post-surgical analgesics, and for the relief of acute musculoskeletal pain. Recent studies suggest that non-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108fb15bd6b6ed04f49b53f9b73790a6
https://doi.org/10.1016/s0736-0266(03)00003-2
https://doi.org/10.1016/s0736-0266(03)00003-2
Autor:
Paola Ciceri, Walter G. Smith, Kathleen M. Leahy, Karen Seibert, Peter C. Isakson, Yan Zhang, Alex Shaffer, Mark B. Woerner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:846-852
Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f10b64c5dfbafa5f45a1f8abb38ba4
https://doi.org/10.1124/jpet.302.3.846
https://doi.org/10.1124/jpet.302.3.846
Autor:
Ian S, Hagemann, Siddhartha, Devarakonda, Christina M, Lockwood, David H, Spencer, Kalin, Guebert, Andrew J, Bredemeyer, Hussam, Al-Kateb, TuDung T, Nguyen, Eric J, Duncavage, Catherine E, Cottrell, Shashikant, Kulkarni, Rakesh, Nagarajan, Karen, Seibert, Maria, Baggstrom, Saiama N, Waqar, John D, Pfeifer, Daniel, Morgensztern, Ramaswamy, Govindan
Publikováno v:
Cancer. 121(4)
A clinical assay was implemented to perform next-generation sequencing (NGS) of genes commonly mutated in multiple cancer types. This report describes the feasibility and diagnostic yield of this assay in 381 consecutive patients with non-small cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::798304cb82c8b437f57dbae370efb5b5
https://pubmed.ncbi.nlm.nih.gov/25345567
https://pubmed.ncbi.nlm.nih.gov/25345567
Autor:
Mark C. WALKER, Ravi G. KURUMBAIL, James R. KIEFER, Kirby T. MORELAND, Carol M. KOBOLDT, Peter C. ISAKSON, Karen SEIBERT, James K. GIERSE
Publikováno v:
Biochemical Journal. 357:709-718
Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms, which include simple competitive, as well as slow binding and irreversible inhibition. In ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9b9e573e979585f32e04be32523c50
https://doi.org/10.1042/bj3570709
https://doi.org/10.1042/bj3570709
Autor:
Mukesh K, Sharma, Joshua, Phillips, Saurabh, Agarwal, Wesley S, Wiggins, Savita, Shrivastava, Sunita B, Koul, Madhurima, Bhattacharjee, Caerie D, Houchins, Raghavendra R, Kalakota, Bijoy, George, Rekha R, Meyer, David H, Spencer, Christina M, Lockwood, Tudung T, Nguyen, Eric J, Duncavage, Hussam, Al-Kateb, Catherine E, Cottrell, Suhasini, Godala, Raviteja, Lokineni, Sameer M, Sawant, Vasudev, Chatti, Suresh, Surampudi, Raja Rao, Sunkishala, Ramakant, Darbha, Sharath, Macharla, Jeffrey D, Milbrandt, Herbert W, Virgin, Robi D, Mitra, Richard D, Head, Shashikant, Kulkarni, Andrew, Bredemeyer, John D, Pfeifer, Karen, Seibert, Rakesh, Nagarajan
Publikováno v:
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. 2013
The use of NextGen Sequencing clinically necessitates the need for informatics tools that support the complete workflow from sample accessioning to data analysis and reporting. To address this need we have developed Clinical Genomicist Workstation (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b593806009fe13345a823cedef468ea1
https://pubmed.ncbi.nlm.nih.gov/24303327
https://pubmed.ncbi.nlm.nih.gov/24303327
Autor:
Karen Seibert, Gary J. Kelloff, Claudio J. Conti, Herng-Hsang Lo, Gary Gordon, Ronald A. Lubet, Susan M. Fischer
Publikováno v:
Molecular Carcinogenesis. 25:231-240
Epidemiological and dietary studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer, possibly through a mechanism involving inhibition of cyclooxygenase (COX)-2, which is overexpressed in premalignant adenom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43713e11c5f280c98ce4067cca3a4e9
https://doi.org/10.1002/(sici)1098-2744(199908)25:4<231::aid-mc1>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199908)25:4<231::aid-mc1>3.0.co
Autor:
Jeffery S. Carter, John J. Talley, Karen Seibert, Stephen R. Bertenshaw, D. Joseph Rogier, Carol M. Koboldt, Graneto Matthew J, David L. Brown, Ben S. Zweifel, Jaime L. Masferrer, Bryan H. Norman
Publikováno v:
Medicinal Research Reviews. 19:199-208
A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe6962fa7e482f1968255b75b942a14
https://doi.org/10.1002/(sici)1098-1128(199905)19:3<199::aid-med1>3.0.co
https://doi.org/10.1002/(sici)1098-1128(199905)19:3<199::aid-med1>3.0.co