Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen, Leavens"'
Autor:
Christopher J. Delves, Caroline O. S. Savage, Tim S. Schmidt, Lea Fortunato, Emilie Charles, Thomas Matthew Webb, Lia Liefaard, Nicolas Wisniacki, John Stone, Rainard Fuhr, Sara Brett, Stephen A. Hughes, Ruth M. Tarzi, Muna Albayaty, Christine Barrett, Ken Edwards, Karen Leavens, Katherine Nevin, Rabia Anselm, Joanne Ellis, Shuo Tang, Martin Coenen, T.G. Hopkins, N Srinivasan, Yi Cui, Daniel J.B. Marks, Anna Richards, Maria Feeney
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:1293-1303
Activated T cells drive a range of immune-mediated inflammatory diseases. LAG-3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We describe the engineering and first-in-human clinical study (NCT02195349) of GSK2831781 (an afucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62756dd9fb9176467d5ec91c6f2f47a
https://doi.org/10.1002/cpt.2091
https://doi.org/10.1002/cpt.2091
Autor:
Karen Leavens, Lucy C. Garner, Stephen A. Hughes, Kevin R. Page, D Krull, Stephanie Slevin, Kate D. Lynch, Ruth M. Tarzi, Carolina V. Arancibia-Cárcamo, Malcolm Tan, Conor Lahiff, B Greenaway, Katherine Nevin, Simon Travis, Helen Ferry, Alessandra Geremia, Lai Mun Wang, Satish Keshav, Marks Djb., Paul Klenerman, N Srinivasan
Publikováno v:
Journal of Crohn's & Colitis
Background and Aims Lymphocyte activation gene [LAG]-3 is an immune checkpoint and its expression identifies recently activated lymphocytes that may contribute to inflammation. We investigated the role of LAG-3 by analysing its expression and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4266795c27d581cd07e3b6ab24470a27
https://pubmed.ncbi.nlm.nih.gov/32179884
https://pubmed.ncbi.nlm.nih.gov/32179884
Autor:
Joanne, Ellis, Daniel, J B Marks, Naren, Srinivasan, Christine, Barrett, Thomas G, Hopkins, Anna, Richards, Rainard, Fuhr, Muna, Albayaty, Martin, Coenen, Lia, Liefaard, Karen, Leavens, Katherine L, Nevin, Shuo, Tang, Stephen A, Hughes, Léa, Fortunato, Ken, Edwards, Yi, Cui, Rabia, Anselm, Christopher J, Delves, Emilie, Charles, Maria, Feeney, Thomas M, Webb, Sara J, Brett, Tim S, Schmidt, John, Stone, Caroline O S, Savage, Nicolas, Wisniacki, Ruth M, Tarzi
Publikováno v:
Clinical Pharmacology and Therapeutics
Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We describe the engineering and first‐in‐human clinical study (NCT02195349) of GSK2831781 (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f23427490f0b1e1cb4970397cb5df0a0
https://pubmed.ncbi.nlm.nih.gov/33113155
https://pubmed.ncbi.nlm.nih.gov/33113155
Autor:
Ruth M. Tarzi, B Greenaway, Marks Djb., Stephen A. Hughes, Katherine Nevin, S Slevin, Kate D. Lynch, M Tan, N Srinivasan, Simon Travis, Conor Lahiff, Satish Keshav, Karen Leavens, Alessandra Geremia, Lai Mun Wang, C Arancibia
Publikováno v:
Journal of Crohn's and Colitis. 13:S033-S033
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfdf279a574a875a1f2908d332774a3
https://doi.org/10.1093/ecco-jcc/jjy222.046
https://doi.org/10.1093/ecco-jcc/jjy222.046
Autor:
Katherine Nevin, Karen Leavens, D Marks, Martin Coenen, J Stone, R Anselm, Anna Richards, Lia Liefaard, Stephen A. Hughes, N Srinivasan, Ruth M. Tarzi, Tim S. Schmidt, Rainard Fuhr, Nicolas Wisniacki, Muna Albayaty, Christine Barrett, Ken Edwards, T.G. Hopkins, S Tang, Joanne Ellis, Caroline O. S. Savage
Publikováno v:
Journal of Crohn's and Colitis. 13:S336-S336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb981551746698e9cd83aa72ab4681a
https://doi.org/10.1093/ecco-jcc/jjy222.573
https://doi.org/10.1093/ecco-jcc/jjy222.573
Autor:
Deborah Needham, Jason A. Holt, Stuart N. Farrow, Robert J. H. Austin, Keith Biggadike, Karen Leavens, Iain Uings, Davina C. Angell, Michael V. Haase, Joyce Lesley Matthews
Publikováno v:
British Journal of Pharmacology. 169:1389-1403
Background and Purpose Glucocorticoids are highly effective therapies for a range of inflammatory diseases. Advances in the understanding of the diverse molecular mechanisms underpinning glucocorticoid action suggest that anti-inflammatory molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25957fdf79777640947506765da7aa8d
https://doi.org/10.1111/bph.12232
https://doi.org/10.1111/bph.12232
Autor:
Nigel Deeks, Karen Leavens, Aarti Patel, Colin A. Campbell, Helen Garden, Jenni Cryan, Emmanuel Hubert Demont, Simon Taylor, Jason Witherington, Pam Gaskin, Andrea C. Haynes, Simon J. Dowell, Robert Willis, James Gray, Mary A. Morse
Publikováno v:
Xenobiotica. 42:671-686
Sphingosine-1-phosphate (S1P(1)) receptor agonists such as Fingolimod (FTY-720) are a novel class of immunomodulators that have clinical utility in the treatment of remitting relapsing multiples sclerosis. This class of compound act by inducing perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f59802bae55cbb59275cfe5a79ad2aa
https://doi.org/10.3109/00498254.2011.645908
https://doi.org/10.3109/00498254.2011.645908
Autor:
Philip Alan Skone, Donald O. Somers, Marion C. Dickson, Nick Smithers, Ann Louise Walker, Thomas George Christopher Hayhow, Stuart G. Leach, Karen Leavens, Clement Douault, Emma J. Jones, Dorothy Elwes, Robert J. Watson, Margarete Neu, Robert P. Davis, Matthew Gray, Neil Stuart Garton, Clare I. Hobbs, Alex Preston, Michael David Barker, Vipulkumar Kantibhai Patel, Cesar Ramirez-Molina, Paul S. Carter, Scott McCleary, Gordon G. Weingarten, Huw D. Lewis, Francis Louis Atkinson, John Liddle, Tracy Jane Shipley, Neil R. Curtis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6188-6194
The lead optimisation of the diaminopyrimidine carboxamide series of spleen tyrosine kinase inhibitors is described. The medicinal chemistry strategy was focused on optimising the human whole blood activity whilst achieving a sufficient margin over l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fce9afb90ca4e724d4726df2268b6f
https://doi.org/10.1016/j.bmcl.2011.07.082
https://doi.org/10.1016/j.bmcl.2011.07.082
Autor:
Slevin, Stephanie M1 (AUTHOR) carolina.arancibia@ndm.ox.ac.uk, Garner, Lucy C1 (AUTHOR), Lahiff, Conor1 (AUTHOR), Tan, Malcolm1 (AUTHOR), Wang, Lai Mun2 (AUTHOR), Ferry, Helen1 (AUTHOR), Greenaway, Borgel1 (AUTHOR), Lynch, Kate1 (AUTHOR), Geremia, Alessandra1 (AUTHOR), Hughes, Stephen3 (AUTHOR), Leavens, Karen3 (AUTHOR), Krull, David4 (AUTHOR), Marks, Daniel J B3 (AUTHOR), Nevin, Katherine3 (AUTHOR), Page, Kevin3 (AUTHOR), Srinivasan, Naren3 (AUTHOR), Tarzi, Ruth3 (AUTHOR), Klenerman, Paul1,5 (AUTHOR), Travis, Simon1 (AUTHOR), Arancibia-Cárcamo, Carolina V1 (AUTHOR) carolina.arancibia@ndm.ox.ac.uk
Publikováno v:
Journal of Crohn's & Colitis. Oct2020, Vol. 14 Issue 10, p1446-1461. 16p.
Autor:
Taylor, Simon1 (AUTHOR) Simon.5.taylor@gsk.com, Gray, James R. J.1 (AUTHOR), Willis, Robert1 (AUTHOR), Deeks, Nigel1 (AUTHOR), Haynes, Andrea1 (AUTHOR), Campbell, Colin1 (AUTHOR), Gaskin, Pam1 (AUTHOR), Leavens, Karen1 (AUTHOR), Demont, Emmanuel1 (AUTHOR), Dowell, Simon2 (AUTHOR), Cryan, Jenni2 (AUTHOR), Morse, Mary1 (AUTHOR), Patel, Aarti3 (AUTHOR), Garden, Helen4 (AUTHOR), Witherington, Jason1 (AUTHOR)
Publikováno v:
Xenobiotica. Jul2012, Vol. 42 Issue 7, p671-686. 16p. 1 Diagram, 4 Charts, 8 Graphs.