Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Karen, Dengel"'
Autor:
Edward A. Stadtmauer, Thomas H. Faitg, Daniel E. Lowther, Ashraf Z. Badros, Karen Chagin, Karen Dengel, Malini Iyengar, Luca Melchiori, Jean-Marc Navenot, Elliot Norry, Trupti Trivedi, Ruoxi Wang, Gwendolyn K. Binder, Rafael Amado, Aaron P. Rapoport
Publikováno v:
Blood Advances, Vol 3, Iss 13, Pp 2022-2034 (2019)
Abstract: This study in patients with relapsed, refractory, or high-risk multiple myeloma (MM) evaluated the safety and activity of autologous T cells engineered to express an affinity-enhanced T-cell receptor (TCR) that recognizes a peptide shared b
Externí odkaz:
https://doaj.org/article/0da426ccc3774f85a6cbfabc8a4520ed
Autor:
Payal D. Shah, Alexander C. Huang, Xiaowei Xu, Robert Orlowski, Ravi K. Amaravadi, Lynn M. Schuchter, Paul Zhang, Julia Tchou, Tina Matlawski, Amanda Cervini, Joanne Shea, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, E. John Wherry, Gerald P. Linette, Andrea Brennan, Vanessa Gonzalez, Irina Kulikovskaya, Simon F. Lacey, Gabriela Plesa, Carl H. June, Robert H. Vonderheide, Tara C. Mitchell
Publikováno v:
Cancer Research Communications. 3:821-829
Purpose: Treatments are limited for metastatic melanoma and metastatic triple-negative breast cancer (mTNBC). This pilot phase I trial (NCT03060356) examined the safety and feasibility of intravenous RNA-electroporated chimeric antigen receptor (CAR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0368480eb756635728b862b5d77d081c
https://doi.org/10.1158/2767-9764.crc-22-0486
https://doi.org/10.1158/2767-9764.crc-22-0486
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Study procedures. Participant study procedures including cell collection/manufacturing timeline as well as infusion schedule from eligibility confirmation onward.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e40732ed1e1a9fe11f9fc7a214caad
https://doi.org/10.1158/2767-9764.22787708.v1
https://doi.org/10.1158/2767-9764.22787708.v1
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Purpose:Treatments are limited for metastatic melanoma and metastatic triple-negative breast cancer (mTNBC). This pilot phase I trial (NCT03060356) examined the safety and feasibility of intravenous RNA-electroporated chimeric antigen receptor (CAR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7637614404a385b771276bf3e332121
https://doi.org/10.1158/2767-9764.c.6547846
https://doi.org/10.1158/2767-9764.c.6547846
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
mRNA signals corresponding to CAR T cells in peripheral blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54192d6fb8fae12a3ddc28ee4aff8747
https://doi.org/10.1158/2767-9764.22787684.v1
https://doi.org/10.1158/2767-9764.22787684.v1
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Supplementary Figure 1.: Representative immunohistochemical staining for Subject 74 with metastatic melanoma; lymph node biopsy. Panel A: pS6 staining prior to infusion; Panel B: pS6 staining at post-infusion biopsy; Panel C: Ki-67 staining prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa5cb6c559cc5419f376cd8cfbce516
https://doi.org/10.1158/2767-9764.22787702
https://doi.org/10.1158/2767-9764.22787702
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Patient population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4077fdb1b2cdd2218fd9e984a2fcdb
https://doi.org/10.1158/2767-9764.22787696.v1
https://doi.org/10.1158/2767-9764.22787696.v1
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44449c921b88f4d8b8397f8fe48c5b26
https://doi.org/10.1158/2767-9764.22787687
https://doi.org/10.1158/2767-9764.22787687
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
Supplementary Figure 2: Representative immunohistochemical staining for Subject 27 with metastatic triple-negative breast cancer; lymph node biopsy. Panel A shows CD8 staining prior to infusion and Panel B shows CD8 staining at the time of post-infus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad98c778eb35b65cea1ce82391d474f
https://doi.org/10.1158/2767-9764.22787699
https://doi.org/10.1158/2767-9764.22787699
Autor:
Tara C. Mitchell, Robert H. Vonderheide, Carl H. June, Gabriela Plesa, Simon F. Lacey, Irina Kulikovskaya, Vanessa Gonzalez, Andrea Brennan, Gerald P. Linette, E. John Wherry, Amy Marshall, Karen Dengel, Lester Lledo, Joan Gilmore, Joanne Shea, Amanda Cervini, Tina Matlawski, Julia Tchou, Paul Zhang, Lynn M. Schuchter, Ravi K. Amaravadi, Robert Orlowski, Xiaowei Xu, Alexander C. Huang, Payal D. Shah
IHC analysis of paired tumor tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2782ac12c0567d21a5186eaae8c7747
https://doi.org/10.1158/2767-9764.22787681
https://doi.org/10.1158/2767-9764.22787681