Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karen, Beltz"'
Autor:
Gebhard Thoma, Rudolf O. Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J. Rudewicz, Hans-Guenter Zerwes
Publikováno v:
Journal of Medicinal Chemistry. 66:2161-2168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f192ba71005a275db9926466bd7974
https://doi.org/10.1021/acs.jmedchem.2c01977
https://doi.org/10.1021/acs.jmedchem.2c01977
Autor:
Kea Martin, Ursula Junker, Elaine Tritto, Esther Sutter, Tina Rubic-Schneider, Hannah Morgan, Satoru Niwa, Jianping Li, Achim Schlapbach, Dana Walker, Marc Bigaud, Christian Beerli, Amanda Littlewood-Evans, Bettina Rudolph, Marc Laisney, David Ledieu, Karen Beltz, Jean Quancard, Frédéric Bornancin, Natasa Zamurovic Ribrioux, Thomas Calzascia
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory T cells (Tregs) and
Externí odkaz:
https://doaj.org/article/92eee817000748258e9659af159c4926
Autor:
Ulf Neumann, Mike Ufer, Laura H Jacobson, Marie‐Laure Rouzade‐Dominguez, Gunilla Huledal, Carine Kolly, Rainer M Lüönd, Rainer Machauer, Siem J Veenstra, Konstanze Hurth, Heinrich Rueeger, Marina Tintelnot‐Blomley, Matthias Staufenbiel, Derya R Shimshek, Ludovic Perrot, Wilfried Frieauff, Valerie Dubost, Hilmar Schiller, Barbara Vogg, Karen Beltz, Alexandre Avrameas, Sandrine Kretz, Nicole Pezous, Jean‐Michel Rondeau, Nicolau Beckmann, Andreas Hartmann, Stefan Vormfelde, Olivier J David, Bruno Galli, Rita Ramos, Ana Graf, Cristina Lopez Lopez
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-18 (2018)
Abstract The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD
Externí odkaz:
https://doaj.org/article/48fbf5e81f1a4f18ae40665093c63175
Autor:
Jean Quancard, Laurence Kieffer, Samu Melkko, Ralf Endres, Martin Renatus, Catherine H. Régnier, Thomas Calzascia, Mickael Sorge, Markus Wartmann, Frédéric Bornancin, Thomas Radimerski, P. Erbel, Carole Pissot Soldermann, Paul M.J. McSheehy, Markus Blatter, Reiner Aichholz, Trixie Wagner, Oliver Simic, Karen Beltz, Marc Bigaud, Achim Schlapbach, Andreas Weiss
Publikováno v:
Journal of Medicinal Chemistry. 63:14594-14608
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a7c1ce6f98fa56490d44e94ead5daa
https://doi.org/10.1021/acs.jmedchem.0c01246
https://doi.org/10.1021/acs.jmedchem.0c01246
Autor:
Amanda Littlewood-Evans, Sophie Sarret, Frédéric Bornancin, Yeter Kolb, Isabelle Isnardi, Jean Quancard, Grazyna Wieczorek, Hans-Guenter Zerwes, Achim Schlapbach, Ratiba Touil, Nadja Caesar, Stephanie Valeaux, Karen Beltz, Thomas Le Meur, Maureen Bardet, Christian Beerli, Jiri Kovarik, Tobias Junt, Thomas Calzascia, Kea Martin, Catherine H. Régnier, Marc Bigaud, Laura Israel, Grozdan Cvijetic, Elena Degl'Innocenti
Publikováno v:
Arthritis & Rheumatology. 72:919-930
Objective Fcγ receptors (FcγR) play important roles in both protective and pathogenic immune responses. The assembly of the CBM signalosome encompassing caspase recruitment domain-containing protein 9, B cell CLL/lymphoma 10, and mucosa-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d875d2102180de2a6699c3ac5aa48f6
https://doi.org/10.1002/art.41204
https://doi.org/10.1002/art.41204
Autor:
Ulf Neumann, Rainer Machauer, Markus Voegtle, Marina Tintelnot-Blomley, Konstanze Hurth, Grit Laue, Siem Jacob Veenstra, Rainer Martin Lueoend, Karen Beltz, Jean-Michel Rondeau, Laura H. Jacobson, Heinrich Rueeger
Publikováno v:
Journal of medicinal chemistry. 64(20)
After identification of lead compound 6, 5-amino-1,4-oxazine BACE1 inhibitors were optimized in order to improve potency, brain penetration, and metabolic stability. Insertion of a methyl and a trifluoromethyl group at the 6-position of the 5-amino-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1684187da4ba38d92544db8bc35d7bf0
https://pubmed.ncbi.nlm.nih.gov/34648711
https://pubmed.ncbi.nlm.nih.gov/34648711
Autor:
Vincent Ribrag, Zev A. Wainberg, Lara Iglesias Docampo, Thiruvamoor Ramkumar, Louise Barys, Shuqi Chen, Marc Raccuglia, Mélanie Wilbaux, Karen Beltz, Amy Luyt, Yu Yun Fan, Naoko Suenaga, Fangjun Luo, Xuan Dai, Clinton Lai, Jia Chen
Publikováno v:
Journal of Clinical Oncology. 40:3083-3083
3083 Background: Polycomb Repressive Complex 2 (PRC2) regulates transcription via trimethylation of histone H3 at lysine 27 (H3K27me3). Its dysregulation and over-expression are associated with tumorigenesis in several conditions. MAK683 is a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1569109d1dbc40c033b5fb588c030d67
https://doi.org/10.1200/jco.2022.40.16_suppl.3083
https://doi.org/10.1200/jco.2022.40.16_suppl.3083
Autor:
Jean, Quancard, Oliver, Simic, Carole, Pissot Soldermann, Reiner, Aichholz, Markus, Blatter, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Ralf, Endres, Mickael, Sorge, Laurence, Kieffer, Trixie, Wagner, Karen, Beltz, Paul, Mcsheehy, Markus, Wartmann, Catherine H, Régnier, Thomas, Calzascia, Thomas, Radimerski, Marc, Bigaud, Andreas, Weiss, Frédéric, Bornancin, Achim, Schlapbach
Publikováno v:
Journal of medicinal chemistry. 63(23)
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95563fb4dabe5dbc98d44b011542ecbe
https://pubmed.ncbi.nlm.nih.gov/33216547
https://pubmed.ncbi.nlm.nih.gov/33216547
Autor:
Arnaud Decock, Paul Erbel, Mickael Sorge, Rene Beerli, Samu Melkko, Frédéric Bornancin, Bertran Rubi, Oliver Simic, Catherine H. Régnier, Carole Pissot-Soldermann, Martin Renatus, Jean Quancard, Achim Schlapbach, Langlois Jean Baptiste Georges Armand, Nikolaus Schiering, Nicola Hughes, Marina Tintelnot-Blomley, Karen Beltz, Frederic Villard, Nicole Buschmann, Carsten Spanka, Christian Wiesmann
Publikováno v:
Advanced Therapeutics. 3:2000078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b9fc30252a7312c68632b24ac2bde3
https://doi.org/10.1002/adtp.202000078
https://doi.org/10.1002/adtp.202000078
Autor:
Valerie Dubost, Bruno Galli, Laura H. Jacobson, Alexandre Avrameas, Wilfried Frieauff, Marie-Laure Rouzade-Dominguez, Konstanze Hurth, Derya R. Shimshek, Ulf Neumann, Nicole Pezous, Ana Graf, Karen Beltz, Jean-Michel Rondeau, Hilmar Schiller, Heinrich Rueeger, Nicolau Beckmann, Siem Jacob Veenstra, Marina Tintelnot-Blomley, Rita Ramos, Sandrine Kretz, Mike Ufer, Rainer Machauer, Stefan Viktor Vormfelde, Cristina Lopez Lopez, Gunilla Huledal, Olivier J. David, Carine Kolly, Andreas Hartmann, Rainer Lüönd, Barbara Vogg, Matthias Staufenbiel, Ludovic Perrot
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 11, Pp n/a-n/a (2018)
EMBO Molecular Medicine, Vol 10, Iss 11, Pp n/a-n/a (2018)
A major hallmark of Alzheimer's disease (AD) is the deposition of amyloid‐beta (Aβ) plaques in the brain. Sequential cleavage of amyloid precursor protein by BACE1 and γ‐secretase generates Aβ. Thus, BACE1 is an attractive AD drug target. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01044e86b3672f81bb8e9b69d171d1be
https://pubmed.ncbi.nlm.nih.gov/30322841
https://pubmed.ncbi.nlm.nih.gov/30322841