Zobrazeno 1 - 10
of 421
pro vyhledávání: '"Karel Svoboda"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cortical neurons exhibit temporally irregular spiking patterns and heterogeneous firing rates. These features arise in model circuits operating in a ‘fluctuation-driven regime’, in which fluctuations in membrane potentials emerge from th
Externí odkaz:
https://doaj.org/article/c6b5be26214a4d6286782658d0c0ad17
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Task-related neural activity is widespread across populations of neurons during goal-directed behaviors. However, little is known about the synaptic reorganization and circuit mechanisms that lead to broad activity changes. Here we trained a
Externí odkaz:
https://doaj.org/article/964f2c15d682446991ea09c268a6bd05
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract A prominent trend in single-cell transcriptomics is providing spatial context alongside a characterization of each cell’s molecular state. This typically requires targeting an a priori selection of genes, often covering less than 1% of the
Externí odkaz:
https://doaj.org/article/f913f1bea7e846a0921d6e4a99bc3c9e
Autor:
Oliver Rübel, Andrew Tritt, Ryan Ly, Benjamin K Dichter, Satrajit Ghosh, Lawrence Niu, Pamela Baker, Ivan Soltesz, Lydia Ng, Karel Svoboda, Loren Frank, Kristofer E Bouchard
Publikováno v:
eLife, Vol 11 (2022)
The neurophysiology of cells and tissues are monitored electrophysiologically and optically in diverse experiments and species, ranging from flies to humans. Understanding the brain requires integration of data across this diversity, and thus these d
Externí odkaz:
https://doaj.org/article/8ccc1bad882a41749568d200faaa782d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
To explain the neural correlates of behavior and its variability, one must analyze single-trial population dynamics. Here, the authors develop a statistical method that extracts low-dimensional dynamics that explain behavior better than high-dimensio
Externí odkaz:
https://doaj.org/article/4354c31399954a5585f1a74a123f387f
Autor:
Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108954- (2021)
Summary: The ability to probe the membrane potential of multiple genetically defined neurons simultaneously would have a profound impact on neuroscience research. Genetically encoded voltage indicators are a promising tool for this purpose, and recen
Externí odkaz:
https://doaj.org/article/988ec148d2284498bbc73d61eb2c37e8
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008198 (2020)
Calcium imaging with fluorescent protein sensors is widely used to record activity in neuronal populations. The transform between neural activity and calcium-related fluorescence involves nonlinearities and low-pass filtering, but the effects of the
Externí odkaz:
https://doaj.org/article/a8139b775ca840208837edeab628626e
Autor:
Nuo Li, Susu Chen, Zengcai V Guo, Han Chen, Yan Huo, Hidehiko K Inagaki, Guang Chen, Courtney Davis, David Hansel, Caiying Guo, Karel Svoboda
Publikováno v:
eLife, Vol 8 (2019)
Optogenetics allows manipulations of genetically and spatially defined neuronal populations with excellent temporal control. However, neurons are coupled with other neurons over multiple length scales, and the effects of localized manipulations thus
Externí odkaz:
https://doaj.org/article/a8116898927a47e18b00713a1a1c1009
Autor:
Aaron Kerlin, Boaz Mohar, Daniel Flickinger, Bryan J MacLennan, Matthew B Dean, Courtney Davis, Nelson Spruston, Karel Svoboda
Publikováno v:
eLife, Vol 8 (2019)
The active properties of dendrites can support local nonlinear operations, but previous imaging and electrophysiological measurements have produced conflicting views regarding the prevalence and selectivity of local nonlinearities in vivo. We imaged
Externí odkaz:
https://doaj.org/article/64ae45c3401d43e1bc24f08fd05eb553
Autor:
Ondřej Navrátil, Kamil Ďuriš, Vilém Juráň, Karel Svoboda, Jakub Hustý, Evžen Hovorka, Eduard Neuman, Andrej Mrlian, Martin Smrčka
Publikováno v:
Brain Sciences, Vol 10, Iss 8, p 501 (2020)
Introduction: Anterior communicating artery aneurysms (ACoAAs) are the most frequent intracranial aneurysms treated at neurosurgical departments with a vascular program. Material and methods: We reviewed patients with ACoAAs in a single institution o
Externí odkaz:
https://doaj.org/article/c0096cefb2ea44bcbed15d1b3d4ce343