Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Karel Souček"'
Autor:
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier,
Externí odkaz:
https://doaj.org/article/e0bd277f452f4f1b9cbd5f9d9804c57b
Autor:
Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil, Karel Souček
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by ci
Externí odkaz:
https://doaj.org/article/76914d3e92714ee7a0aaef1af6d4853f
Autor:
Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil, Karel Souček
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/cff4987ab1db4d198c785431d344a9ff
Autor:
Barbora Kvokačková, Radek Fedr, Daniela Kužílková, Jan Stuchlý, Adéla Vávrová, Jiří Navrátil, Pavel Fabian, Róbert Ondruššek, Petra Ovesná, Ján Remšík, Jan Bouchal, Tomáš Kalina, Karel Souček
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 1024-1040 (2023)
Triple‐negative breast cancer (TNBC) is an aggressive and complex subtype of breast cancer that lacks targeted therapy. TNBC manifests characteristic, extensive intratumoral heterogeneity that promotes disease progression and influences drug respon
Externí odkaz:
https://doaj.org/article/902a68d47202494e8964ad7e6e6c97dc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection system, as well as t
Externí odkaz:
https://doaj.org/article/b028f155bd954024864a1e10325a277c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/91e4cbb22d284d98a4e0cedad096ca1c
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Ondřej Vacek, Jana Pokludová, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody–drug conjugate targeting Trop2 were recently approved for cancer therapy, th
Externí odkaz:
https://doaj.org/article/ec7ff7a2fa694aecb1011c9f0a61909f
Autor:
Róbert Ondruššek, Barbora Kvokačková, Karolína Kryštofová, Světlana Brychtová, Karel Souček, Jan Bouchal
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration of leukocytes which might
Externí odkaz:
https://doaj.org/article/a800b1488e63491993a6731823ab25a0
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja
Publikováno v:
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Externí odkaz:
https://doaj.org/article/429690658a42429e81ef4cee4109bc0b