Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Karel Smetana"'
Autor:
Radek Sindelka, Ravindra Naraine, Pavel Abaffy, Daniel Zucha, Daniel Kraus, Jiri Netusil, Karel Smetana, Lukas Lacina, Berwini Beduya Endaya, Jiri Neuzil, Martin Psenicka, Mikael Kubista
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background Embryos are regeneration and wound healing masters. They rapidly close wounds and scarlessly remodel and regenerate injured tissue. Regeneration has been extensively studied in many animal models using new tools such as single-cel
Externí odkaz:
https://doaj.org/article/ec44e75ff06d4af7b54c5b332a61430b
Autor:
Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical i
Externí odkaz:
https://doaj.org/article/60f3248bbe5d4cae877f072b508159d0
Publikováno v:
European Journal of Histochemistry, Vol 68, Iss 3 (2024)
The present study was undertaken to provide more information on the peripheral RNA containing ring of ringshaped nucleoli (RSNo). Human lymphocytes of blood donors and patients suffering from B chronic lymphocytic leukemia mostly characterized by RSN
Externí odkaz:
https://doaj.org/article/f249dff696a74e2d89a5565c9353e4af
Autor:
Nikita Abramenko, Fréderic Vellieux, Kateřina Veselá, Zdeněk Kejík, Jan Hajduch, Michal Masařík, Petr Babula, David Hoskovec, Karel Pacák, Pavel Martásek, Karel Smetana, Milan Jakubek
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Immune checkpoints regulate the immune system response. Recent studies suggest that flavonoids, known as phytoestrogens, may inhibit the PD-1/PD-L1 axis. We explored the potential of estrogens and 17 Selective Estrogen Receptor Modulators (S
Externí odkaz:
https://doaj.org/article/031511e97a734e7a80fb86a3fbb5fcab
Autor:
Vladimír Procházka, Lukáš Lacina, Karel Smetana, Martin Svoboda, Kateřina Skřivanová, Miroslava Beňovská, Jiří Jarkovský, Leoš Křen, Zdeněk Kala
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method A total of 115 patients underwent colorectal
Externí odkaz:
https://doaj.org/article/cc15f446f0e64a3fb365ee7f1237680f
Autor:
Pavla Taborska, Pavol Lukac, Dmitry Stakheev, Lenka Rajsiglova, Katerina Kalkusova, Karolina Strnadova, Lukas Lacina, Barbora Dvorankova, Jiri Novotny, Michal Kolar, Milena Vrana, Hana Cechova, Sarka Ransdorfova, Marie Valerianova, Karel Smetana, Luca Vannucci, Daniel Smrz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Soft tissue sarcomas are aggressive mesenchymal-origin malignancies. Undifferentiated pleomorphic sarcoma (UPS) belongs to the aggressive, high-grade, and least characterized sarcoma subtype, affecting multiple tissues and metastasizing to m
Externí odkaz:
https://doaj.org/article/1c9be3a664094753adfc79a34419345c
Autor:
Michaela Tesařová, Lenka Peterková, Monika Šťastná, Michal Kolář, Lukáš Lacina, Karel Smetana, Radovan Hynek, Jan Betka, Aleš Vlasák, Petr Lukeš, Zdeněk Fík
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 32 (2022)
Vestibular schwannoma is the most common benign neoplasm of the cerebellopontine angle. It arises from Schwann cells of the vestibular nerve. The first symptoms of vestibular schwannoma include hearing loss, tinnitus, and vestibular symptoms. In the
Externí odkaz:
https://doaj.org/article/5aef85744f6f4f5b84334891727bad21
Autor:
Magdalena Rašková, Lukáš Lacina, Zdeněk Kejík, Anna Venhauerová, Markéta Skaličková, Michal Kolář, Milan Jakubek, Daniel Rosel, Karel Smetana, Jan Brábek
Publikováno v:
Cells, Vol 11, Iss 22, p 3698 (2022)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunit
Externí odkaz:
https://doaj.org/article/d08376423f0544388824b7da040f3086
Autor:
Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana, Milan Jakubek
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1712 (2022)
IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively studied strategy in cancer treatment. We desc
Externí odkaz:
https://doaj.org/article/f251712b9341489a865b0ae337bc3d58
Publikováno v:
Folia Histochemica et Cytobiologica, Vol 46, Iss 4, Pp 429-432 (2009)
The present study was undertaken to provide information on the nucleolar and cytoplasmic density in specimens stained for RNA during "cell dedifferentiation" represented by blastic transformation of mature T lymphocytes. Nucleolar and cytoplasmic RNA
Externí odkaz:
https://doaj.org/article/5943a1bf048a408b841c6655a1c07da6