Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Karel Pomeisl"'
Publikováno v:
Molecules, Vol 25, Iss 3, p 497 (2020)
In our work, we developed the synthesis of new polyfunctional pegylated trehalose derivatives and evaluated their cryoprotective effect using flow cytometry. We showed that new compounds (modified trehaloses) bound to appropriate extracellular polyme
Externí odkaz:
https://doaj.org/article/a2ce232418a24d50ab9fbd770e3d59c8
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 1, Iss 1, p 17 (2005)
Substituted 3-(fluoroacyloxy)quinoline-2,4(1H,3H)-diones including 3-(fluoroiodoacetoxy) derivatives react with triethyl phosphite to afford either the product of the Perkow reaction or the corresponding 4-ethoxyquinolin-2(1H)-one. In both reactions,
Externí odkaz:
https://doaj.org/article/3705f848829d442882f4479ca74b93c0
Publikováno v:
Journal of Separation Science. 45:2217-2227
A new approach for the evaluation of chiral purity of serine esterification products bearing long-chain alkyl substituents was developed. The compounds were simply converted to aryl-substituted oxazolines which: (i) facilitates effective chromatograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dadfd5b735213509dcd7fd305303c8
https://doi.org/10.1002/jssc.202100958
https://doi.org/10.1002/jssc.202100958
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 38:119-156
Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5de78474e62df8ad62af9f92eec55d
https://doi.org/10.1080/15257770.2018.1506884
https://doi.org/10.1080/15257770.2018.1506884
Autor:
Marcela Krečmerová, Karel Pomeisl, Helena Mertlíková-Kaiserová, Radek Pohl, Jakub Benýšek, Alice Pomeislová, Petra Rubešová, Lenka Poštová Slavětínská, Marika Matousova, Miroslav Otmar
Publikováno v:
Bioorganicmedicinal chemistry. 32
In analogy to antiviral acyclic nucleoside phosphonates, a series of 5-amino-3-oxo-1,2,4-thiadiazol-3(2H)-ones bearing a 2-phosphonomethoxyethyl (PME) or 3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) group at the position 2 of the heterocyclic moiety h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b42389a753bae8bdc8be32aba4b25f9
https://pubmed.ncbi.nlm.nih.gov/33440320
https://pubmed.ncbi.nlm.nih.gov/33440320
Autor:
Martin Dračínský, Karel Pomeisl, Robert Snoeck, Jan Balzarini, Marcela Krečmerová, Graciela Andrei
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alko
New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d00865b6aa78f9a0f05c006927b8fb3
http://europepmc.org/articles/PMC7126465
http://europepmc.org/articles/PMC7126465
Publikováno v:
ChemistrySelect. 1:2102-2106
A novel efficient method for the synthesis of gem-difluorinated derivatives of acyclic nucleotide analogues has been developed. The method is based on utilization of diethyl difluoromethylphosphonate as a nucleophilic difluoromethylation reagent. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c6f306a7c6143e67a7cc4a5f9824b8
https://doi.org/10.1002/slct.201600445
https://doi.org/10.1002/slct.201600445
Autor:
Jana Brabcová, Veronika Šolínová, Nikola Lamatová, Karel Pomeisl, Václav Kašička, Marcela Krečmerová, Radek Pohl
Publikováno v:
Bioorganicmedicinal chemistry. 27(7)
An enzymatic alternative to the chemical synthesis of chiral gem-difluorinated alcohols has been developed. The method is highly effective and stereoselective, feasible at laboratory temperature, avoiding the use of toxic heavy metal catalysts which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5b7da5d3f02c9277a44d332c7d3a53
https://pubmed.ncbi.nlm.nih.gov/30777664
https://pubmed.ncbi.nlm.nih.gov/30777664
Autor:
Jan Richter, Jakub Šebera, Iva Falková, Shelby E. Follett, K. Wade Elliott, Júlia Mičová, David Řeha, Daniel Šimek, Karel Pomeisl, Martin Golan, Irena Kratochvílová, Martin Falk, Silvia Sedláková, Krisztina Varga
Publikováno v:
RSC advances. 7(1)
In this work the physico-chemical properties of selected cryoprotectants (antifreeze protein TrxA-AFP752, trehalose and dimethyl sulfoxide) were correlated with their impact on the constitution of ice and influence on frozen/thawed cell viability. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8c66fdca62815d787218c4083116ec
https://pubmed.ncbi.nlm.nih.gov/28936355
https://pubmed.ncbi.nlm.nih.gov/28936355
Publikováno v:
Tetrahedron
With respect to the strong antiviral activity of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine various types of its side chain fluorinated analogues were prepared. The title compound, (S)-1-[3-fluoro-2-(phosphonomethoxy)propyl]-5-azacyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a19e1afde34e56d870828502c0a1b72
http://europepmc.org/articles/PMC7111758
http://europepmc.org/articles/PMC7111758