Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karel Piron"'
Publikováno v:
ARKIVOC, Vol 2012, Iss 5, Pp 6-15 (2011)
Externí odkaz:
https://doaj.org/article/5b04828b8769426cb303078a31f1df99
Autor:
Frederik Deroose, Karel Piron, Riccardo Surmont, Peter ten Holte, Sara Kenis, Norbert De Kimpe, Guido Verniest, Jan Willem Thuring
Publikováno v:
Tetrahedron. 68:6941-6947
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d803ba749790b60b745eb89a36481f3
https://doi.org/10.1016/j.tet.2012.05.122
https://doi.org/10.1016/j.tet.2012.05.122
Autor:
Karel Piron, Riccardo Surmont, Norbert De Kimpe, Guido Verniest, Sara Kenis, Peter ten Holte, Frederik Deroose, Jan Willem Thuring
Publikováno v:
ChemInform. 44
A copper-mediated cross-coupling of difluoroacetate (II) with haloarenes followed by hydrolysis of the nitrile group/cyclization gives access to title compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d8b0a0f0ce32ca09c566ac75637428
https://doi.org/10.1002/chin.201301140
https://doi.org/10.1002/chin.201301140
Publikováno v:
ARKIVOC, Vol 2012, Iss 5, Pp 6-15 (2011)
A synthetic route towards 1-t-butoxycarbonyl-3-fluoro-3-methylpyrrolidine and 1-t- butoxycarbonyl-3-fluoro-3-methylazetidine, which are interesting building blocks for pharmaceutical compounds, is described. The key steps include a bromofluorination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d12025f9ff3f09ad9ef3490fd09fe5
https://biblio.vub.ac.be/vubir/synthesis-of-3fluoropyrrolidines-and-3fluoroazetidines(f0a75aa0-425a-4eac-ac19-ba1309cd21db).html
https://biblio.vub.ac.be/vubir/synthesis-of-3fluoropyrrolidines-and-3fluoroazetidines(f0a75aa0-425a-4eac-ac19-ba1309cd21db).html
Autor:
Norbert De Kimpe, Guido Verniest, Eva Van Hende, Gregor Macdonald, Frederik Deroose, Karel Piron, Jan Willem Thuring
Publikováno v:
ChemInform. 41
Key step of the title synthesis is the regioselective bromofluorination of methylenepiperidines and -pyrrolidines (I) with NBS and Et3N·3HF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f576fc4bcb43cc39f1ff11556579e7cf
https://doi.org/10.1002/chin.201043148
https://doi.org/10.1002/chin.201043148
Autor:
Guido Verniest, Eva Van Hende, Gregor Macdonald, Norbert De Kimpe, Karel Piron, Jan Willem Thuring, Frederik Deroose
Publikováno v:
Organicbiomolecular chemistry. 8(11)
A short and efficient synthesis of 4-aminomethyl-4-fluoropiperidines and 3-aminomethyl-3-fluoropyrrolidines is described. These fluorinated azaheterocycles are of specific interest as bifunctional building blocks for fluorinated pharmaceutical compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce52366547981bd9d774dd7e5121bd3
https://pubmed.ncbi.nlm.nih.gov/20407687
https://pubmed.ncbi.nlm.nih.gov/20407687