Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Karel Palát"'
Autor:
Vera Klimesova, Petra Herzigová, Karel Palát, Miloš Macháček, Jiřina Stolaříková, Hans Martin Dahse, Ute Möllmann
Publikováno v:
ARKIVOC, Vol 2012, Iss 3, Pp 90-103 (2012)
Externí odkaz:
https://doaj.org/article/4d612f14f0044a81b9181082900c53d7
Autor:
Géza Regdon, Karel Palát, Jan Loskot, Klára Konečná, Juraj Martiska, Eva Snejdrova, Mária Budai-Szűcs, Georgios Paraskevopoulos, Andrej Kováčik
Publikováno v:
European Journal of Pharmaceutical Sciences. 163:105855
As proven in clinical trials, superficial fungal infections can be effectively treated by single topical application of terbinafine hydrochloride (Ter-HCl) in a film forming system (FFS). Poly(lactic-co-glycolic acid) (PLGA) derivatives, originally s
Autor:
Jiří Kuneš, Karel Palát, Jiřina Stolaříková, Vladimír Wsól, Vladimír Buchta, Rainer Beckert, Karel Waisser, Eva Novotná
Publikováno v:
Archiv der Pharmazie. 347:381-386
New quaternary ammonium salt-type compounds with lipophilic cholesterol and terpene moieties were synthesized. The compounds showed promising antibacterial and antimycobacterial activities. Those compounds containing the cholesterol moiety showed sig
Autor:
Alexandr Hrabálek, Jaroslav Roh, Pavel Berka, Jarmila Zbytovská, Kateřina Vávrová, Karel Palát, Barbora Janůšová, Barbora Školová, Gert S. Gooris, Joke A. Bouwstra, Petr Slepička
Publikováno v:
Langmuir. 29:15624-15633
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However, the structural requirements and mechanisms of actio
Publikováno v:
Tetrahedron. 69:1705-1711
Contrary to a number of reports, alkylations of the privileged 3,4-dihydroquinazoline scaffold provide N3-alkylated products, and not 4-alkoxyquinazolines. To correctly assign the structure, 13C NMR shifts of the –Z–CHn– (Z=O, N) fragment are n
Autor:
Ute Möllmann, Hans-Martin Dahse, Karel Palát, Věra Klimešová, Eva Petrlikova, Jiří Kuneš, Jarmila Kaustová, Milan Peřina, Karel Waisser
Publikováno v:
European Journal of Medicinal Chemistry. 45:2719-2725
New 3-benzyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-benzyl-2H-1,3-benzoxazine-2,4(3H)-dithiones were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii and M
Autor:
Aleš Růžička, Juana Monreal Férriz, Aleš Imramovský, Karel Palát, Martin Krátký, Jarmila Vinšová, Antonín Lyčka
Publikováno v:
Tetrahedron Letters. 51:23-26
The preparation of new prodrug forms of anti-tuberculosis active salicylanilide esters with amino acids led to an unexpected rearrangement. The isolation and the structure determination of 2-(5-chloro-2-hydroxyphenyl)-3-(3-chlorophenyl)-5-substituted
Autor:
Josef Matyk, Jarmila Kaustová, Petra Husáková, Hana Divišová, Karel Waisser, Jiri Kunes, Vera Klimesova, Karel Palát
Publikováno v:
Archiv der Pharmazie. 340:264-267
Based on our previous studies, 21 new halogenated 3-(4-alkylphenyl)-1,3-benzoxazine-2,4-(3H)-diones were synthesized by the reaction of salicylanilides and methyl-chloroformate. All compounds were screened in vitro against three different strains of
Publikováno v:
Electrochimica Acta. 50:1431-1437
The quantitative structure–property relationships study of 40 benzoxazines, that seem to be very promising antimycobacterial drugs, allowed proposing and testing of the equations describing effects of substituents on half-wave potentials of these c
Publikováno v:
Journal of Physical Organic Chemistry. 17:686-693
The principle of steric hindrance to resonance (SIR) was revised on the well-known example of the electronic spectra of methyl-substituted acetophenones. The spectra were reinvestigated on an extended series 1–14, and computer separation of bands w