Výsledky vyhledávání - "Karel P.M. Heirwegh"

Analysis of Bilirubins in Biological Fluids by Extraction and Thin-Layer Chromatography of the Intact Tetrapyrroles: Application to Bile of Patients with Gilbert's Syndrome, Hemolysis, or Cholelithiasis

Autor: Pol Leroy, J Fevery, Karel P.M. Heirwegh, Roger Michiels, Norbert Blanckaert

Publikováno v: Hepatology. 3:177-183

A method was developed to extract quantitatively the bilirubins from bile, urine, serum, stool, and preparations from liver with a chloroform-ethanol mixture at pH 1.8 in the presence of ascorbic acid and NaCl. Extracted pigment was submitted to thin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7244b43ccfc31b7fc510b2c6e99bafa6
https://doi.org/10.1002/hep.1840030207

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Multiphasic modelling of ligand/acceptor interactions. The hydrophobicity-dependent binding of relatively small amphiphilic substances to acceptor proteins and the nature and facedness of acceptor sites

Autor: Zahur Zaman, Karel P.M. Heirwegh, Marc Vermeir

Publikováno v: Journal of Biochemical and Biophysical Methods. 29:23-47

The modelling of multiphasic ligand/acceptor equilibrium binding systems proceeds at three logically distinct levels: (1) A suitable response quantity, e.g. the amount of acceptor-bound ligand n EL , is expressed as a function of the ligand concentra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c537a2f1991f3519176d4b5abee23ac3
https://doi.org/10.1016/0165-022x(94)90055-8

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Modelling of interaction of basic lipophilic ligands with cytochrome P-450 reconstituted in liposomes. Determination of membrane partition coefficients of S-( − )-nicotine and N,N-diethylaniline from spectral binding studies and fluorescence quenching

Autor: Karel P.M. Heirwegh, Noël Boens, Marc Vermeir

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1107:93-104

The spectral interaction of N , N -diethylaniline and S -( − )-nicotine with cytochrome P450IIB4 reconstituted into large unilamellar vesicles could property be described by a model for interaction of basic lipid-soluble ligands with membrane-bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eadfb92b144e85bb1efd65fb2904d9f
https://doi.org/10.1016/0005-2736(92)90333-h

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Analysis of membrane-bound acceptors

Autor: Karel P.M. Heirwegh, Humbert De Smedt, Marc Vermeir

Publikováno v: Biochemical Pharmacology. 43:701-704

Non-specific ligand accumulation into membrane material, which may contribute considerably to the experimental signal obtained in binding studies with labelled amphipathic and hydrophobic ligands, may be accounted for by linear partition of the ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::441d250e97c70377bdefc192bbae8e32
https://doi.org/10.1016/0006-2952(92)90233-9

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Synthesis, chromatographic purification, and analysis of isomers of biliverdin IX and bilirubin IX

Autor: Karel P.M. Heirwegh, Gustaaf P. Van Hees, Norbert Blanckaert

Publikováno v: Analytical Biochemistry. 195:273-278

Neutral solvent systems were developed to isolate the alpha, beta, gamma, and delta isomers of biliverdin IX dimethyl ester by TLC. The individual free acids of biliverdin IX were obtained by saponification of the corresponding dimethyl esters. The b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763244f632a544b557c95005c8caab91
https://doi.org/10.1016/0003-2697(91)90329-r

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Testing and characterizing enzymes and membrane-bound carrier proteins acting on amphipathic ligands in the presence of bilayer membrane material and soluble binding protein. Application to the uptake of oleate into isolated cells

Autor: Jules A. T. P. Meuwissen, Karel P.M. Heirwegh

Publikováno v: The Biochemical journal. 284

1. A multiphasic modelling approach [Heirwegh, Meuwissen, Vermeir & De Smedt (1988) Biochem. J. 254, 101-108] is applied to systems containing poorly water-soluble amphipathic reactants, membrane material, soluble binding protein and acceptor protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baca3b82f8650d9609378d4cb8336ab
https://pubmed.ncbi.nlm.nih.gov/1599418

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