Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Karel Otero"'
Autor:
Alex Pellerin, Karel Otero, Julie M Czerkowicz, Hannah M Kerns, Renée I Shapiro, Ann M Ranger, Kevin L Otipoby, Frederick R Taylor, Thomas O Cameron, Joanne L Viney, Dania Rabah
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 4, Pp 464-476 (2015)
Abstract Type I interferons (IFN‐I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the sec
Externí odkaz:
https://doaj.org/article/9ceab9bde5004b959003e383c7a33823
Akademický článek
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Publikováno v:
Journal of Alzheimer's Disease; 2022, Vol. 88 Issue 3, p837-847, 11p
Autor:
Lawrence Rajendran, Alice Canzi, Laura Piccio, Valerio Zerbi, Matteo Tamborini, Rosa C. Paolicelli, Raffaella Morini, Stefania Vetrano, Fabio Perrucci, Marco Erreni, Elisabetta Menna, Francesca Cignarella, Bernadeta Michalski, Margaret Fahnestock, Karel Otero, Marco Genua, Irene Corradini, Fabia Filipello, Chiara Starvaggi-Cucuzza, Michela Matteoli, Marija Markicevic
Publikováno v:
Immunity
The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease, and with an increased risk of Alzheimer's disease. Microglial defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04c02199d5667fe2850d50d17423dcf
https://www.zora.uzh.ch/id/eprint/167227/
https://www.zora.uzh.ch/id/eprint/167227/
Autor:
Dania Rabah, Thomas Cameron, Alex Pellerin, Hannah M. Kerns, Frederick R. Taylor, Kevin L. Otipoby, Julie Czerkowicz, Renee I. Shapiro, Karel Otero, Ann Ranger, Joanne L. Viney
Publikováno v:
EMBO Molecular Medicine
Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6bf43a25332ae182f915a160b4209e
http://europepmc.org/articles/PMC4403047
http://europepmc.org/articles/PMC4403047
Autor:
Claire Green, Karel Otero, J. Robin Highley, Johnathan Cooper-Knock, Pamela J. Shaw, Wenbin Wei, Bryan J. Traynor, Gabriel Altschuler, Janine Kirby, Paul R. Heath, Joanna J. Bury, Winston Hide, Kathryn Doyle, Matthew Wyles, Alejandro Lorente-Pons, Tim Beck, Catherine Gelsthorpe
Publikováno v:
Acta Neuropathologica Communications
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream mechanisms has yet to predict disease progression in the clinic. Ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e526169c43bcb9c4d7dfd4779ff60
Autor:
Thomas O. Moninger, Susan Gilfillan, Xiaopeng Li, Joseph Zabner, Kathy Keck, Marco Colonna, Cory J. Knudson, Steven M. Varga, Julia Klesney-Tait, Karel Otero, David K. Meyerholz, Sankar Baruah, Jessica G. Moreland
Publikováno v:
Journal of Clinical Investigation. 123:138-149
Acute respiratory infections are responsible for more than 4 million deaths each year. Neutrophils play an essential role in the innate immune response to lung infection. These cells have an armamentarium of pattern recognition molecules and antimicr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac49d929d795a0be901b6330885f2827
https://doi.org/10.1172/jci64181
https://doi.org/10.1172/jci64181
Autor:
F. Patrick Ross, Haibo Zhao, Steve L. Teitelbaum, Susan Gilfillan, Marina Cella, Karel Otero, Hiroshi Takayanagi, Roberta Faccio, Marco Colonna, Masahiro Shinohara, Angela Colucci
Publikováno v:
The Journal of Immunology. 188:2612-2621
TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12. Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu–Hakola disease (NHD) with cystic-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c61d5fbbbd7341757ac2f1a871e5d4
https://doi.org/10.4049/jimmunol.1102836
https://doi.org/10.4049/jimmunol.1102836
Autor:
Felipe García, Rosa Baos, Maria Carmen González-León, Francisco Arnalich, Eduardo López-Collazo, Pablo Fuentes-Prior, Llanos Soler-Ranger, Lourdes Gómez-García, Karel Otero, Pedro Escoll, Luis Caveda, Carlos del Fresno
Publikováno v:
Scopus-Elsevier
Although blood monocytes possess significant cytotoxic activity against tumor cells, tumor-infiltrating monocytes are commonly deactivated in cancer patients. Monocytes pre-exposed to tumor cells show significantly decreased expression levels of TNF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb35dec8a7b91deb0194c9b3b7495ef3
https://doi.org/10.4049/jimmunol.174.5.3032
https://doi.org/10.4049/jimmunol.174.5.3032
Autor:
Karel Otero, Giuseppe Peri, Annunciata Vecchi, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
Publikováno v:
Clinical Experimental Allergy Reviews. 4:150-154
Summary Pentraxin 3 (PTX3), the first long pentraxin identified, is characterized by a C-terminal pentraxin like domain, showing sequence similarity to C-reactive protein and serum amyloid P component, coupled with a N-terminal unrelated portion. PTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d543e131ac9f357712db84de2a3b560e
https://doi.org/10.1111/j.1472-9725.2004.00048.x
https://doi.org/10.1111/j.1472-9725.2004.00048.x