Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Karel Mikulík"'
Publikováno v:
International Journal of Engineering Research and Science. 3:46-57
It is becoming interestingly apparent that innovations of the classical antibiotics are not effective, that induces need for novel drugs. Peptide antibiotics exhibit a group of secondary metabolites with hydrophobic and cyclic structures containing d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f773043b565e3a82f0a1ec019a7c9d1
https://doi.org/10.25125/engineering-journal-ijoer-apr-2017-15
https://doi.org/10.25125/engineering-journal-ijoer-apr-2017-15
Publikováno v:
Applied Microbiology and Biotechnology. 98:7185-7197
The aim of this study was to contribute to clarifying the role of 6S RNA in the development and control of antibiotic biosynthesis in Streptomyces coelicolor. Due to the low energetic cost of gene silencing via 6S RNA, it is an easy and rapid means o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04e5e246235dd0296598c594ab909dd
https://doi.org/10.1007/s00253-014-5806-4
https://doi.org/10.1007/s00253-014-5806-4
Publikováno v:
Mol. BioSyst.. 7:817-823
The occurrence of phosphorylated proteins in ribosomes of Streptomyces coelicolor was investigated. Little is known about which biological functions these posttranslational modifications might fulfil. A protein kinase associated with ribosomes phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0db19814f3378882aa2d246b50d376e
https://doi.org/10.1039/c0mb00174k
https://doi.org/10.1039/c0mb00174k
Publikováno v:
Microbial Biotechnology. 2:114-122
Streptomycetes are soil microorganisms with the potential to produce a broad spectrum of secondary metabolities. The production of antibiotics is accompanied by a decrease in protein synthesis, which raises the question of how these bacteria survived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b03e7513849b4228d90a8453aab5425
https://doi.org/10.1111/j.1751-7915.2008.00066.x
https://doi.org/10.1111/j.1751-7915.2008.00066.x
Publikováno v:
Folia Microbiologica. 52:463-470
tmRNA and protein SmpB are the main components required for rescue of stalled ribosomes incapable of properly elongating or terminating the polypeptide chain. We examined the tmRNA level and protein synthesis in Streptomyces aureofaciens, S. griseus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd80ed7e54e01d75e7ddd2055418af7
https://doi.org/10.1007/bf02932105
https://doi.org/10.1007/bf02932105
Autor:
K. Kontrova, V. Škop, Petr Mlejnek, Michal Pravenec, J. Sajdok, Jarmila Zídková, Karel Mikulík, Ludmila Kazdova, Vaclav Zidek, B. Bartos
Publikováno v:
Publons
Europe PubMed Central
Europe PubMed Central
In the current study, we tested a hypothesis that CD36 fatty acid (FA) transporter might affect insulin sensitivity by indirect effects on FA composition of adipose tissue. We examined the effects of CD36 downregulation by RNA interference in 3T3-L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaab13cd92a80384427383f00a4c8a9
https://doi.org/10.33549/physiolres.931324
https://doi.org/10.33549/physiolres.931324
Publikováno v:
Folia Microbiologica. 51:517-524
Transition from exponential phase of growth to stationary phase in Streptomyces aureofaciens is characterized by a decrease in the rate of translation and induction of tetracycline (Ttc) biosynthesis. In exponential phase, no significant changes were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8529e5c95053046c32b66de7ee66a70a
https://doi.org/10.1007/bf02931615
https://doi.org/10.1007/bf02931615
Autor:
Karel Mikulík
Publikováno v:
Folia Microbiologica. 48:443-468
Most biochemical, computational and genetic approaches to gene finding assume the Central Dogma and look for genes that make mRNA and have ORFs. These approaches essentially do not work for one class of genes — the noncoding RNA. In all living orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee45fe1e17346b5502b703f5486e478
https://doi.org/10.1007/bf02931326
https://doi.org/10.1007/bf02931326
Publikováno v:
Biochemical and Biophysical Research Communications. 299:335-342
Dormant aerial spores of Streptomyces granaticolor contain pre-existing pool of mRNA and active ribosomes for rapid translation of proteins required for earlier steps of germination. Activated spores were labeled for 30 min with [35S]methionine/cyste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151030c872b6675a45be06dbd99b45f8
https://doi.org/10.1016/s0006-291x(02)02606-2
https://doi.org/10.1016/s0006-291x(02)02606-2
Publikováno v:
Biochemical and Biophysical Research Communications. 289:434-443
Protein kinase associated with ribosomes of streptomycetes phosphorylates 11 ribosomal proteins. Phosphorylation activity of protein kinase reaches its maximum at the end of exponential phase of growth. When (32)P-labeled cells from the end of expone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fad9c8536289c06994536fc2dae54c6
https://doi.org/10.1006/bbrc.2001.6017
https://doi.org/10.1006/bbrc.2001.6017