Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karel Guillemyn"'
Autor:
Karel Guillemyn, Joanna Mika, Barbara Przewlocka, Wioletta Makuch, Steven Ballet, Joanna Starnowska
Publikováno v:
European Journal of Pharmaceutical Sciences. 104:221-229
A bifunctional peptide containing an opioid and nociceptin receptor-binding pharmacophore, H-Dmt-D-Arg-Aba-β-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2 (KGNOP1), was tested for its analgesic properties when administered intrathecally in naive and chronic const
Autor:
Armand Drieu la Rochelle, Karel Guillemyn, Maria Dumitrascuta, Simon Gonzalez, Charlotte Martin, Valérie Utard, Raphaëlle Quillet, Séverine Schneider, François Daubeuf, Tom Willemse, Pieter Mampuys, Bert Maes, Nelly Frossard, Frédéric Bihel, Mariana Spetea, Frédéric Simonin, Steven Ballet
Publikováno v:
Proceedings of the 35th European Peptide Symposium.
Autor:
Steven Ballet, Armand Drieu la Rochelle, Pieter Mampuys, Valérie Utard, Frédéric Bihel, Séverine Schneider, Mariana Spetea, François Daubeuf, Karel Guillemyn, Tom Willemse, Maria Dumitrascuta, Nelly Frossard, Bert U. W. Maes, Raphaëlle Quillet, Charlotte Martin, Frédéric Simonin
Publikováno v:
Pain
PAIN
PAIN, Elsevier, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩
PAIN
PAIN, Elsevier, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩
Opioid analgesics, such as morphine, oxycodone and fentanyl, are the cornerstones for treating moderate to severe pain. However, upon chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and depend
Autor:
Steven Ballet, Toon Laeremans, Els Pardon, Peter Kolb, Karel Guillemyn, Cecilia Betti, Florent Chevillard, Jan Steyaert
Publikováno v:
Angewandte Chemie (International ed. in English). 57(19)
The conformational complexity of transmembrane signaling of G-protein-coupled receptors (GPCRs) is a central hurdle for the design of screens for receptor agonists. In their basal states, GPCRs have lower affinities for agonists compared to their G-p
Autor:
Steven Ballet, Zofia Urbanczyk-Lipkowska, Olivier Van der Poorten, Dirk Tourwé, Karel Guillemyn, Mouhamad Jida
Publikováno v:
Organic Letters. 17:4482-4485
A new convenient, mild, one-pot procedure is described for the diastereoselective synthesis of constrained 7,5- and 7,6-fused azabicycloalkanes. Using 2-formyl-L-tryptophan and 2-formyl-l-phenylalanine as bielectrophilic building blocks, T3P-mediated
Autor:
Louis Gendron, Dirk Tourwé, Frédéric Bihel, Nga N. Chung, Peter W. Schiller, Olivier Van der Poorten, Cecilia Betti, Robin Van Den Hauwe, Karel Guillemyn, Emilie Eiselt, Steven Ballet, François Hallé, Philippe Sarret
Publikováno v:
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, American Chemical Society, 2017, 8 (11), pp.1177-1182. ⟨10.1021/acsmedchemlett.7b00347⟩
ACS Medicinal Chemistry Letters, American Chemical Society, 2017, 8 (11), pp.1177-1182. ⟨10.1021/acsmedchemlett.7b00347⟩
Herein, the synthesis of novel conformationally constrained amino acids, 4-amino-8-bromo-2-benzazepin-3-one (8-Br-Aba), 3-amino-3,4-dihydroquinolin-2-one, and regioisomeric 4-amino-naphthoazepinones (1- and 2-Ana), is described. Introduction of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb26d3a07e8388d155d1e134bca1b18
https://hal.archives-ouvertes.fr/hal-02368778
https://hal.archives-ouvertes.fr/hal-02368778
Autor:
Joanna Mika, Joost Van Duppen, Katarzyna Popiolek-Barczyk, Attila Keresztes, John M. Streicher, Peter W. Schiller, Karel Guillemyn, Steven Ballet, Adriano Mollica, Jozef Vanden Broeck, Joanna Starnowska, Carole Lemieux, Barbara Przewlocka, Roberto Costante, Dirk Tourwé, Nga N. Chung
The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdd56be47ca77328f58848e3431857d
https://lirias.kuleuven.be/handle/123456789/632022
https://lirias.kuleuven.be/handle/123456789/632022
Autor:
Camille, Lagard, Lucie, Chevillard, Karel, Guillemyn, Patricia, Risède, Jean-Louis, Laplanche, Mariana, Spetea, Steven, Ballet, Bruno, Mégarbane
Publikováno v:
PAIN
PAIN, 2017, 158 (3), pp.505-515. ⟨10.1097/j.pain.0000000000000790⟩
Pain
PAIN, 2017, 158 (3), pp.505-515. ⟨10.1097/j.pain.0000000000000790⟩
Pain
KGNOP1, a mu-opioid receptor agonist/nociceptin receptor antagonist hybrid, can dually treat experimental neuropathic and nociceptive pain, more efficiently and safely than tramadol and morphine, respectively.
Drugs able to treat both nociceptiv
Drugs able to treat both nociceptiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5595615accbe581dac8cbb23488e885c
https://hal.science/hal-03822929
https://hal.science/hal-03822929
Autor:
José C. Martins, Georges Laus, Falk Hildebrand, Lumeng Ye, Pierre Cornelis, Karel Guillemyn, Sandra Matthijs, Jeroen Raes, Steven Ballet
Publikováno v:
BioMetals. 26:561-575
The structure of a pyoverdine produced by Pseudomonas putida, W15Oct28, was elucidated by combining mass spectrometric methods and bioinformatics by the analysis of non-ribosomal peptide synthetase genes present in the newly sequenced genome. The onl
Publikováno v:
Journal of Peptide Science. 19:423-432
A model octapeptide segment derived from vasoactive intestinal peptide (VIP) was utilised to investigate the effect of several conventional cyclisation methods on the α-helical conformation in short peptide fragments. Three of the classical macrocyc