Zobrazeno 1 - 10
of 982
pro vyhledávání: '"Karel Geboes"'
Autor:
Fernando Magro, Joana Afonso, Susana Lopes, Rosa Coelho, Raquel Gonçalves, Paulo Caldeira, Paula Lago, Helena Tavares de Sousa, Jaime Ramos, Ana Rita Gonçalves, Paula Ministro, Isadora Rosa, Ana Isabel Vieira, Patrícia Andrade, João-Bruno Soares, Diana Carvalho, Paula Sousa, Tânia Meira, Joanne Lopes, Joana Moleiro, Cláudia Camila Dias, Amílcar Falcão, Karel Geboes, Fatima Carneiro
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 123-130 (2017)
Although infliximab (IFX) is an efficient therapy for ulcerative colitis (UC) patients, a considerably high rate of therapeutic failures still occurs. This study aimed at a better understanding of IFX pharmacokinetics and pharmacodynamics among clini
Externí odkaz:
https://doaj.org/article/66bba5e0ad61429c9860e5a97a1af101
Autor:
Magali de Bruyn, Christine Breynaert, Ingrid Arijs, Gert De Hertogh, Karel Geboes, Greet Thijs, Gianluca Matteoli, Jialiang Hu, Jo Van Damme, Bernd Arnold, Marc Ferrante, Séverine Vermeire, Gert Van Assche, Ghislain Opdenakker
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challe
Externí odkaz:
https://doaj.org/article/cf83337903164ea1a97bfb338b28091a
Autor:
Fernando Magro, Joana Afonso, Susana Lopes, Rosa Coelho, Raquel Gonçalves, Paulo Caldeira, Paula Lago, Helena Tavares de Sousa, Jaime Ramos, Ana Rita Gonçalves, Paula Ministro, Isadora Rosa, Tânia Meira, Patrícia Andrade, João-Bruno Soares, Diana Carvalho, Paula Sousa, Ana Isabel Vieira, Joanne Lopes, Cláudia Camila Dias, Karel Geboes, Fátima Carneiro
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. Me
Externí odkaz:
https://doaj.org/article/885d11d90096428ba3ae8c798129dddd
Autor:
Ahmed M. Abu El-Asrar, Mohammad Mairaj Siddiquei, Mohd Imtiaz Nawaz, Karel Geboes, Ghulam Mohammad
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/5b28ba49d8274acfa0b62ae2ce621b46
Autor:
Karel Geboes, Paul Rutgeerts
Publikováno v:
Canadian Journal of Gastroenterology, Vol 13, Iss 8, Pp 671-678 (1999)
Dysplasia is a morphological term that ethymologically means ‘malformation’. For the definition of inflammatory bowel disease-related dysplasia, the nature and origin of the malformation are stressed and the lesion is defined as an epithelial mal
Externí odkaz:
https://doaj.org/article/a3e388a62a0c41b2b9007dce6f7d9f40
Autor:
Ahmed M Abu El-Asrar, Ghulam Mohammad, Gert De Hertogh, Mohd Imtiaz Nawaz, Kathleen Van Den Eynde, Mohammad Mairaj Siddiquei, Sofie Struyf, Ghislain Opdenakker, Karel Geboes
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65472 (2013)
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and
Externí odkaz:
https://doaj.org/article/4269333631c641ada1224aeebe9ee3c0
Autor:
Christine Breynaert, Tom Dresselaers, Clémentine Perrier, Ingrid Arijs, Jonathan Cremer, Leentje Van Lommel, Kristel Van Steen, Marc Ferrante, Frans Schuit, Séverine Vermeire, Paul Rutgeerts, Uwe Himmelreich, Jan L Ceuppens, Karel Geboes, Gert Van Assche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68876 (2013)
INTRODUCTION: Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate changes in connective tissue in a chronic murine model resulting from repeated cyc
Externí odkaz:
https://doaj.org/article/320431136fd349cba405ca1f73028adb
Autor:
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Dustan Kangave, Mohammed Mairaj Siddiquei, Karel Geboes
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
This study was conducted to determine levels of angiogenic and endothelial progenitor cell mobilizing (vasculogenic) factors in vitreous fluid from proliferative diabetic retinopathy (PDR) patients and correlate their levels with clinical disease act
Externí odkaz:
https://doaj.org/article/ea553bd6d2b94b39b9efe56807a55f34
Autor:
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Dustan Kangave, Mohammed Mairaj Siddiquei, Karel Geboes
Publikováno v:
Mediators of Inflammation, Vol 2012 (2012)
The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment epithelium-d
Externí odkaz:
https://doaj.org/article/666ae21870384f2e979b42498c425fe8
Autor:
Ingrid Arijs, Gert De Hertogh, Katleen Lemaire, Roel Quintens, Leentje Van Lommel, Kristel Van Steen, Peter Leemans, Isabelle Cleynen, Gert Van Assche, Séverine Vermeire, Karel Geboes, Frans Schuit, Paul Rutgeerts
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7984 (2009)
Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear whether this is a primary defect. We investigated the impact
Externí odkaz:
https://doaj.org/article/978b6a491a764ca8882f96453e283597