Výsledky vyhledávání

Akademický článek

M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background The immunological microenvironment of primary high-grade serous carcinomas (HGSCs) has a major impact on disease outcome. Conversely, little is known on the microenvironment of metastatic HGSCs and its potential influence on patient surviv

Externí odkaz: https://doaj.org/article/0c6e706e32b54f77a1056e1dbd1de54b

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Akademický článek

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch

Autor: Michaela Novakova, Marketa Zaliova, Karel Fiser, Barbora Vakrmanova, Lucie Slamova, Alena Musilova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Jan Stary, Lucie Winkowska, Peter Svec, Alexandra Kolenova, Jan Stuchly, Jan Zuna, Jan Trka, Ondrej Hrusak, Ester Mejstrikova

Publikováno v: Haematologica, Vol 106, Iss 8 (2020)

Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype with early switch to the monocytic lineage and loss of the B-cell immunophenotype, including CD19 expression. Thus far, the genetic background has remained unknown

Externí odkaz: https://doaj.org/article/26a5eaf9193b48aaadedfbc17dd78bfa

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Akademický článek

Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation

Autor: Katerina Rejlova, Alena Musilova, Karolina Skvarova Kramarzova, Marketa Zaliova, Karel Fiser, Meritxell Alberich-Jorda, Jan Trka, Julia Starkova

Publikováno v: Epigenetics, Vol 13, Iss 1, Pp 73-84 (2018)

Homeobox (HOX) genes are frequently dysregulated in leukemia. Previous studies have shown that aberrant HOX gene expression accompanies leukemogenesis and affects disease progression and leukemia patient survival. Patients with acute myeloid leukemia

Externí odkaz: https://doaj.org/article/a78aec922106463abf4d02495cb9f808

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Akademický článek

ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity

Autor: Marketa Zaliova, Eliska Potuckova, Lenka Hovorkova, Alena Musilova, Lucie Winkowska, Karel Fiser, Jan Stuchly, Ester Mejstrikova, Julia Starkova, Jan Zuna, Jan Stary, Jan Trka

Publikováno v: Haematologica, Vol 104, Iss 7 (2019)

ERG-deletions occur recurrently in acute lymphoblastic leukemia, especially in the DUX4-rearranged subtype. The ERG-deletion was shown to positively impact prognosis of patients with IKZF1-deletion and its presence precludes assignment into IKZF1plus

Externí odkaz: https://doaj.org/article/b3ac0ac530c4478aaf403b9a1428838a

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Akademický článek

Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort

Autor: Marketa Zaliova, Jan Stuchly, Lucie Winkowska, Alena Musilova, Karel Fiser, Martina Slamova, Julia Starkova, Martina Vaskova, Ondrej Hrusak, Lucie Sramkova, Jan Stary, Jan Zuna, Jan Trka

Publikováno v: Haematologica, Vol 104, Iss 7 (2019)

Novel biological subtypes and clinically important genetic aberrations (druggable lesions, prognostic factors) have been described in B-other acute lymphoblastic leukemia (ALL) during the last decade; however, due to a lack of studies on unselected c

Externí odkaz: https://doaj.org/article/83a31a02ffa84184a5cd3db59a615b50

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Akademický článek

What matters in chronic Burkholderia cenocepacia infection in cystic fibrosis: Insights from comparative genomics.

Autor: Jaroslav Nunvar, Vaclav Capek, Karel Fiser, Libor Fila, Pavel Drevinek

Publikováno v: PLoS Pathogens, Vol 13, Iss 12, p e1006762 (2017)

Burkholderia cenocepacia causes severe pulmonary infections in cystic fibrosis (CF) patients. Since the bacterium is virtually untreatable by antibiotics, chronic infections persist for years and might develop into fatal septic pneumonia (cepacia syn

Externí odkaz: https://doaj.org/article/a3fb40c43d8a4887863252daffb1c7f0

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Akademický článek

High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction.

Autor: Jedrzej Hoffmann, Karel Fiser, Jolanta Weaver, Ian Dimmick, Monika Loeher, Hanspeter Pircher, Carmen Martin-Ruiz, Murugapathy Veerasamy, Bernard Keavney, Thomas von Zglinicki, Ioakim Spyridopoulos

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47155 (2012)

With the advent of primary PCI (PPCI), reperfusion is achieved in almost all patients presenting with acute myocardial infarction. However, despite multiple trials, reperfusion injury has not been successfully dealt with so far. In mouse models, CD4(

Externí odkaz: https://doaj.org/article/51ba67aa2ac74d3e8008c04bff83a21c

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