Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Karel Chalupsky"'
Autor:
Jan Silhan, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must encode for its own RNA processing machinery includi
Externí odkaz:
https://doaj.org/article/54fb64d84fe748cfbb69a1da79700d89
Autor:
Olga Zbodakova, Karel Chalupsky, Lenka Sarnova, Petr Kasparek, Marketa Jirouskova, Martin Gregor, Radislav Sedlacek
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract ADAM10 and ADAM17 are proteases that affect multiple signalling pathways by releasing molecules from the cell surface. As their substrate specificities partially overlaps, we investigated their concurrent role in liver regeneration and fibro
Externí odkaz:
https://doaj.org/article/df2cddcbdde34b69ae1e9c24d053e8ad
Autor:
Magdalena Prochazkova, Eva Budinska, Marek Kuzma, Helena Pelantova, Jaromir Hradecky, Marie Heczkova, Nikola Daskova, Miriam Bratova, Istvan Modos, Petra Videnska, Petra Splichalova, Solomon A. Sowah, Maria Kralova, Marina Henikova, Eliska Selinger, Krystof Klima, Karel Chalupsky, Radislav Sedlacek, Rikard Landberg, Tilman Kühn, Jan Gojda, Monika Cahova
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
Background and Aim: Plant-based diets are associated with potential health benefits, but the contribution of gut microbiota remains to be clarified. We aimed to identify differences in key features of microbiome composition and function with relevanc
Externí odkaz:
https://doaj.org/article/7249aa0957844c08a6133b5aa1e0fae7
Autor:
Damir Kračun, Mathieu Klop, Anna Knirsch, Andreas Petry, Ivan Kanchev, Karel Chalupsky, Cordula M. Wolf, Agnes Görlach
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101536- (2020)
Cardiovascular side effects are frequent problems accompanying systemic glucocorticoid therapy, although the underlying mechanisms are not fully resolved. Reactive oxygen species (ROS) have been shown to promote various cardiovascular diseases althou
Externí odkaz:
https://doaj.org/article/a4f07484a45345499585bb06c18b0fa4
Autor:
Kamila Bechynska, Vit Kosek, Marie Fenclova, Lucie Muchova, Vaclav Smid, Jakub Suk, Karel Chalupsky, Eva Sticova, Kamila Hurkova, Jana Hajslova, Libor Vitek, Milena Stranska
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1723 (2021)
Milk thistle-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum) is often used for the treatment of liver diseases because of the presence of its active component, silymarin. However, the co-oc
Externí odkaz:
https://doaj.org/article/783e6e9e5ffe452894cf65d603c43fb2
Autor:
Vladimira Horova, Barbora Landova, Jan Hodek, Karel Chalupsky, Petra Krafcikova, Dominika Chalupska, Vojtech Duchoslav, Jan Weber, Evzen Boura, Martin Klima
Publikováno v:
Viruses, Vol 13, Iss 8, p 1487 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 pandemic. One of the key components of the coronavirus replication complex are the RNA methyltransferases (MTases), RNA-modifying enzyme
Externí odkaz:
https://doaj.org/article/3beeeef5e93940659d181dfbb4333ecf
Autor:
Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova, Karel Chalupsky, Tomas Smutny, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Publikováno v:
Cells, Vol 9, Iss 12, p 2532 (2020)
The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activa
Externí odkaz:
https://doaj.org/article/7c2b6c2d073147058fe91e7104860ab2
Autor:
Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M Beck, Radislav Sedlacek
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006566 (2017)
Netherton syndrome (NS) is a severe skin disease caused by the loss of protease inhibitor LEKTI, which leads to the dysregulation of epidermal proteases and severe skin-barrier defects. KLK5 was proposed as a major protease in NS pathology, however i
Externí odkaz:
https://doaj.org/article/bd44d971be1a4155b195a02dcfec4518
Autor:
Marketa Jirouskova, Olga Zbodakova, Martin Gregor, Karel Chalupsky, Lenka Sarnova, Marian Hajduch, Jiri Ehrmann, Marie Jirkovska, Radislav Sedlacek
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46271 (2012)
Liver fibrosis is characterized by the deposition and increased turnover of extracellular matrix. This process is controlled by matrix metalloproteinases (MMPs), whose expression and activity dynamically change during injury progression. MMP-19, one
Externí odkaz:
https://doaj.org/article/8ebda6d687b94eca8e27db87a7348f72
Autor:
Kateřina Krejčová, Petra Krafcikova, Martin Klima, Dominika Chalupska, Karel Chalupsky, Eva Zilecka, Evzen Boura
Flaviviruses are single-stranded positive-sense RNA (+RNA) viruses that are responsible for several (re)emerging diseases such as Yellow, Dengue or West Nile fevers. The Zika epidemic highlighted their dangerousness when a relatively benign virus kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830f8ec44e306c79f175c80c18590afe
https://doi.org/10.1101/2023.05.03.539197
https://doi.org/10.1101/2023.05.03.539197