Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Karel A van Dort"'
Autor:
Thijs Booiman, Vladimir V Loukachov, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144229 (2015)
Transcription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host transcript
Externí odkaz:
https://doaj.org/article/5fad737902604a6d9f715af2e1ec1346
Autor:
Eloy Cuadrado, Thijs Booiman, John L van Hamme, Machiel H Jansen, Karel A van Dort, Adeline Vanderver, Gillian I Rice, Yanick J Crow, Neeltje A Kootstra, Taco W Kuijpers
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143613 (2015)
Unlike resting CD4+ T cells, activated CD4+T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and macrophages without activating the nucleic acid sensors and the anti-viral type I interferon r
Externí odkaz:
https://doaj.org/article/d06d1f73c7034b34910f667c3dc8179b
Autor:
Thijs Booiman, Viviana Cobos Jiménez, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109673 (2014)
BACKGROUND:HIV-1 infected macrophages play a key role in HIV-1 infection. Even during anti-retroviral treatment, macrophages keep producing virus due to suboptimal tissue penetration and reduced efficacy of antiretrovirals. It is therefore of major i
Externí odkaz:
https://doaj.org/article/6a9a382fabd644cf806f66ec2f23b193
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3975 (2008)
BACKGROUND: Previous studies have demonstrated an association between polymorphisms in the regulatory regions of Cyclophilin A (CypA) and susceptibility to both HIV-1 infection and disease progression. Here we studied whether these polymorphisms are
Externí odkaz:
https://doaj.org/article/f9a5424d13d74d8e996165c6964149f4
Autor:
Myrthe L. Verburgh, Lisa van Pul, Marloes Grobben, Anders Boyd, Ferdinand W. N. M. Wit, Ad C. van Nuenen, Karel A. van Dort, Khadija Tejjani, Jacqueline van Rijswijk, Margreet Bakker, Lia van der Hoek, Maarten F. Schim van der Loeff, Marc van der Valk, Marit J. van Gils, Neeltje A. Kootstra, Peter Reiss
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Few studies have comprehensively compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced and hybrid B- and T-cell responses in people with HIV (PWH) to those in comparable controls without HIV. We included 195 P
Externí odkaz:
https://doaj.org/article/e41f2eae979f452e9fbb2e5eaf37db88
Autor:
Vladimir V. Loukachov, Karel A. van Dort, Irma Maurer, R. Bart Takkenberg, Anniki de Niet, Henk W. Reesink, Sophie B. Willemse, Neeltje A. Kootstra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Background and AimsWith current standard of care a functional cure for Chronic Hepatitis B (CHB) is only achieved in 1-3% of patients and therefore novel therapies are needed. Disease activity during CHB can be determined by a broad range of virologi
Externí odkaz:
https://doaj.org/article/7d1b1f66e52d4143b82e49dffa1fa3d9
Publikováno v:
Viruses, Vol 14, Iss 6, p 1223 (2022)
Hepatitis B Virus (HBV) encoded miRNAs were previously described and suggested to play a role in HBV replication and pathogenesis. In this study we aim to identify novel HBV encoded miRNAs in plasma and liver tissue samples from chronic hepatitis B (
Externí odkaz:
https://doaj.org/article/99637bd72eae4bd981d41767d465fe93
Autor:
Zita Kruize, Ad C. van Nuenen, Stan W. van Wijk, Arginell F. Girigorie, Karel A. van Dort, Thijs Booiman, Neeltje A. Kootstra
Publikováno v:
Viruses, Vol 13, Iss 3, p 423 (2021)
Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC). He
Externí odkaz:
https://doaj.org/article/d9addb0636644bda8fd7da4b09037f9c
Autor:
Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Publikováno v:
Viruses, Vol 12, Iss 7, p 764 (2020)
The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to suppress these responses. Two linked single nucleotide polymorphisms (SNPs) in the MAVS gene
Externí odkaz:
https://doaj.org/article/5e0729a89e67458e89bd07ae1f7bb3a6
Autor:
Vladimir V. Loukachov, Karel A. van Dort, Irma Maurer, R. Bart Takkenberg, Anniki de Niet, Henk W. Reesink, Sophie B. Willemse, Neeltje A. Kootstra
Publikováno v:
Frontiers in cellular and infection microbiology, 12:790964. Frontiers Media S.A.
Background and AimsWith current standard of care a functional cure for Chronic Hepatitis B (CHB) is only achieved in 1-3% of patients and therefore novel therapies are needed. Disease activity during CHB can be determined by a broad range of virologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46496bde0368e06963174d7239f1a3d1
https://pubmed.ncbi.nlm.nih.gov/35719345
https://pubmed.ncbi.nlm.nih.gov/35719345