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Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.

Autor: Forteza MJ; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Berg M; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Edsfeldt A; Cardiovascular Research Translational Studies, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, 20 502, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Carl-Bertil Laurells gata 9, 21 428, Malmö, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Jan Waldenströms gata 35, 20 502, Malmö, Sweden., Sun J; Cardiovascular Research Translational Studies, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, 20 502, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Carl-Bertil Laurells gata 9, 21 428, Malmö, Sweden., Baumgartner R; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Kareinen I; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Casagrande FB; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Hedin U; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Zhang S; Mayo Clinic Metabolomics Core, Mayo Clinic, 200, First St. SW Rochester, MN 55905, USA.; Department of Cardiovascular Medicine, Mayo Clinic, 200, First St. SW Rochester, MN 55905, USA., Vuckovic I; Mayo Clinic Metabolomics Core, Mayo Clinic, 200, First St. SW Rochester, MN 55905, USA., Dzeja PP; Department of Cardiovascular Medicine, Mayo Clinic, 200, First St. SW Rochester, MN 55905, USA., Polyzos KA; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Gisterå A; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Trauelsen M; Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3A, 2200, Copenhagen, Denmark., Schwartz TW; Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3A, 2200, Copenhagen, Denmark., Dib L; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7FY, UK., Herrmann J; Department of Cardiovascular Medicine, Mayo Clinic, 200, First St. SW Rochester, MN 55905, USA., Monaco C; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7FY, UK., Matic L; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden., Gonçalves I; Cardiovascular Research Translational Studies, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, 20 502, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Carl-Bertil Laurells gata 9, 21 428, Malmö, Sweden., Ketelhuth DFJ; Center for Molecular Medicine, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Instutet, BioClinicum, Solnavägen 30, Solna, 17 164, Stockholm, Sweden.; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws vej 21, 5000 Odense, Denmark.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2023 Jul 04; Vol. 119 (7), pp. 1524-1536.

Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model.

Autor: Arora A; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden.; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense-C, Denmark., Tripodi GL; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil., Kareinen I; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden., Berg M; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden., Forteza MJ; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden., Gisterå A; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden., Griepke S; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense-C, Denmark., Casagrande FB; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil., Martins JO; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil., Abdalla DSP; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil., Cole J; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Monaco C; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Ketelhuth DFJ; Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden.; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense-C, Denmark.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 06; Vol. 23 (9). Date of Electronic Publication: 2022 May 06.

Severe Spontaneous Atherosclerosis in two Korat Breed Cats is Comparable to Human Atherosclerosis.

Autor: Karkamo V; Production and Companion Animal Pathology Section, Finnish Food Authority, Helsinki, Finland. Electronic address: veera.karkamo@foodauthority.fi., Airas N; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Lindén J; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Hagner K; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Mäyränpää MI; Department of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kovanen PT; Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland., Sukura A; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Kareinen I; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Publikováno v: Journal of comparative pathology [J Comp Pathol] 2021 Oct; Vol. 188, pp. 52-61. Date of Electronic Publication: 2021 Sep 24.

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

Autor: Kareinen I., Cedó L., Silvennoinen R., Laurila P.-P., Jauhiainen M., Julve J., Blanco-Vaca F., Escola-Gil J.C., Kovanen P.T., Lee-Rueckert M.

Publikováno v: JOURNAL OF LIPID RESEARCH
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Reverse cholesterol transport (RCT) pathway from macrophage foam cells initiates when HDL particles cross the endothelium, enter the interstitial fluid, and induce cholesterol efflux from these cells. We injected [ 3 H] cholesterol-loaded J774 macrop

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