Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer

Autor: Jamal-Hanjani, M., Wilson, G.A., Horswell, S., Mitter, R., Sakarya, O., Constantin, T., Salari, R., Kirkizlar, E., Sigurjonsson, S., Pelham, R., Kareht, S., Zimmermann, B., Swanton, C. ^*

Publikováno v: In Annals of Oncology May 2016 27(5):862-867

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution

Autor: Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Quesne, JL, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Bakir, MA, GrÖnroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Quinn, AM, Crosbie, P, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, Swanton, C, Bosshard-Carter, L, Goh, G, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Horswell, S, Al Bakir, M, Mitter, R, Escudero, M, Xu, H, Goldman, J, Stone, RK, Denner, T, Biggs, J, Costa, M, Begum, S, Phillimore, B, Nye, E, Graca, S, Joshi, K, Furness, A, Aissa, AB, Wong, YNS, Georgiou, A, Quezada, S, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Forster, M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Taylor, M, Choudhary, J, Califano, R, Taylor, P, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Moss, S, Idries, F, Bishop, P, Chaturved, A, Marie Quinn, A, Doran, H, leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Rogan, J, Smith, E, Tugwood, J, Brady, G, Rothwell, DG, Chemi, F, Pierce, J, Gulati, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Djearaman, M, Fennell, D, Le Quesne, J, Moore, D, Thomas, A, Walter, H, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Primrose, L, Amadi, A, Palmer, S, Miller, J, Buchan, K, Lester, J, Edwards, A, Morgan, F, Verjee, A, MacKenzie, M, Wilcox, M, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Tavares Barbosa, M, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Elena Cufari, M, Ronquillo, JC, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, AG, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, AD, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Constatin, T, Zimmermann, B, Dentro, S, Dessimoz, C, Shiu, K-K, Bridgewater, J, Hochauser, D, Beck, S, Parker, P, Walczak, H, Enver, T, Proctor, I, Sinclair, R, Lok, C-W, Mitchison, M, Trevisan, G, Lynch, M, Brandner, S, Gishen, F, Tookman, A, Stone, P, Sterling, C, Larkin, J, Attard, G, Eeles, R, Foster, C, Bova, S, Sottoriva, A, Chowdhury, S, Ashish, C, Spicer, J, Stares, M, Lynch, J, Caldas, C, Brenton, J, Fitzgerald, R, Jimenez-Linan, M, Provenzano, E, Cluroe, A, Stewart, G, Watts, C, Gilbertson, R, McDermott, U, Tavare, S, Maughan, T, Tomlinson, I, Campbell, P, McNeish, I, Biankin, A, Chambers, A, Fraser, S, Oien, K, Krebs, M, Marais, R, Carter, L, Nonaka, D, Dhomen, N, Shaw, J, Baijal, S, Tanchel, B, Collard, M, Cockcroft, P, Taylor, J, Colloby, P, Olisemeke, B, Wilson, R, Harrison, D, Loda, M, Flanagan, A, McKenzie, M, Lederman, J, Sharp, A, Farrelly, L

Publikováno v: Nature, vol. 545, no. 7655, pp. 446-451

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488928e0797fc6a75de4915f82e9cf29
https://orca.cardiff.ac.uk/id/eprint/100264/1/nature22364.pdf

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Autor: Abbosh C; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Birkbak NJ; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Wilson GA; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Constantin T; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Salari R; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Le Quesne J; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Moore DA; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Rosenthal R; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Marafioti T; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Department of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK., Kirkizlar E; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Watkins TBK; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Ward S; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Advanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Martinson L; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Riley J; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Fraioli F; Department of Nuclear Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK., Al Bakir M; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Grönroos E; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Zambrana F; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Endozo R; Department of Nuclear Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK., Bi WL; Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Fennessy FM; Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Sponer N; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Johnson D; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Laycock J; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Shafi S; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Czyzewska-Khan J; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Rowan A; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Chambers T; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Advanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Matthews N; Advanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Tumour Profiling Unit Genomics Facility, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK., Turajlic S; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Renal and Skin Units, The Royal Marsden Hospital, London SW3 6JJ, UK., Hiley C; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Lee SM; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Department of Oncology, University College London Hospitals, 250 Euston Road, London NW1 2BU, UK., Forster MD; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Department of Oncology, University College London Hospitals, 250 Euston Road, London NW1 2BU, UK., Ahmad T; Department of Oncology, University College London Hospitals, 250 Euston Road, London NW1 2BU, UK., Falzon M; Department of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK., Borg E; Department of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK., Lawrence D; Department of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Hayward M; Department of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Kolvekar S; Department of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Panagiotopoulos N; Department of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Janes SM; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Department of Respiratory Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.; Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK., Thakrar R; Department of Respiratory Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Ahmed A; Department of Radiology, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK., Blackhall F; Institute of Cancer Studies, University of Manchester, Oxford Road, Manchester M13 9PL, UK.; The Christie Hospital, Manchester M20 4BX, UK., Summers Y; The Christie Hospital, Manchester M20 4BX, UK., Hafez D; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Naik A; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Ganguly A; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Kareht S; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Shah R; Department of Cardiothoracic Surgery, University Hospital South Manchester, Manchester M23 9LT, UK., Joseph L; Department of Pathology, University Hospital South Manchester, Manchester M23 9LT, UK., Marie Quinn A; Department of Pathology, University Hospital South Manchester, Manchester M23 9LT, UK., Crosbie PA; North West Lung Centre, University Hospital South Manchester, Manchester M23 9LT, UK., Naidu B; Department of Thoracic Surgery, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.; Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK. University College London Hospitals NHS Foundation Trust, London, UK., Middleton G; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK., Langman G; Department of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK., Trotter S; Department of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK., Nicolson M; Department of Medical Oncology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK., Remmen H; Department of Cardiothoracic Surgery, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK., Kerr K; Department of Pathology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK., Chetty M; Department of Respiratory Medicine, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK., Gomersall L; Department of Radiology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK., Fennell DA; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Nakas A; Department of Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK., Rathinam S; Department of Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK., Anand G; Department of Radiotherapy, North Middlesex University Hospital, London N18 1QX, UK., Khan S; Department of Respiratory Medicine, Royal Free Hospital, Pond Street, London NW3 2QG, UK.; Department of Respiratory Medicine, Barnet and Chase Farm Hospitals, Wellhouse Lane, Barnet EN5 3DJ, UK., Russell P; Department of Respiratory Medicine, The Princess Alexandra Hospital, Hamstel Road, Harlow CM20 1QX, UK., Ezhil V; Department of Clinical Oncology, St.Luke's Cancer Centre, Royal Surrey County Hospital, Guildford GU2 7XX, UK., Ismail B; Department of Pathology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK., Irvin-Sellers M; Department of Respiratory Medicine, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK., Prakash V; Department of Radiology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK., Lester JF; Department of Clinical Oncology, Velindre Hospital, Cardiff CF14 2TL, UK., Kornaszewska M; Department of Cardiothoracic Surgery, University Hospital of Wales, Cardiff CF14 4XW, UK., Attanoos R; Department of Cellular Pathology, University Hospital of Wales and Cardiff University, Heath Park, Cardiff, UK., Adams H; Department of Radiology, University Hospital Llandough, Cardiff CF64 2XX, UK., Davies H; Department of Respiratory Medicine, University Hospital Llandough, Cardiff CF64 2XX, UK., Oukrif D; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Akarca AU; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Hartley JA; University College London Experimental Cancer Medicine Centre GCLP Facility, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Lowe HL; University College London Experimental Cancer Medicine Centre GCLP Facility, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Lock S; Department of Respiratory Medicine, The Whittington Hospital NHS Trust, London, N19 5NF, UK., Iles N; University College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK., Bell H; University College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK., Ngai Y; University College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK., Elgar G; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Advanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Szallasi Z; Centre for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.; Computational Health Informatics Program (CHIP), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary., Schwarz RF; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany., Herrero J; Bill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Stewart A; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Quezada SA; Cancer Immunology Unit, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK., Peggs KS; Cancer Immunology Unit, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Research Department of Haematology, University College Cancer Institute, London WC1E 6DD, UK., Van Loo P; Cancer Genomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium., Dive C; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK., Lin CJ; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Rabinowitz M; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Aerts HJWL; Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215-5450, USA., Hackshaw A; University College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK., Shaw JA; Cancer Studies, University of Leicester, Leicester LE2 7LX, UK., Zimmermann BG; Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Publikováno v: Nature [Nature] 2017 Apr 26; Vol. 545 (7655), pp. 446-451.