Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kareem N Mohni"'
Autor:
Kareem N Mohni, Petria S Thompson, Jessica W Luzwick, Gloria G Glick, Christopher S Pendleton, Brian D Lehmann, Jennifer A Pietenpol, David Cortez
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125482 (2015)
The DNA damage response kinase ATR may be a useful cancer therapeutic target. ATR inhibition synergizes with loss of ERCC1, ATM, XRCC1 and DNA damaging chemotherapy agents. Clinical trials have begun using ATR inhibitors in combination with cisplatin
Externí odkaz:
https://doaj.org/article/f9c69894fe6f41d8ba3ba6c828bd46d4
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003652 (2013)
Herpes Simplex Virus type 1 (HSV-1) has evolved to disable the cellular DNA damage response kinase, ATR. We have previously shown that HSV-1-infected cells are unable to phosphorylate the ATR substrate Chk1, even under conditions in which replication
Externí odkaz:
https://doaj.org/article/82ad8553ab924d2196e8260f79f0c6d1
Autor:
April J Schumacher, Kareem N Mohni, Yinan Kan, Eric A Hendrickson, Jeremy M Stark, Sandra K Weller
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002862 (2012)
Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been propos
Externí odkaz:
https://doaj.org/article/751feac02ab846c08c4e260d54ba26af
XLSX file - 201K, Results from the ATRi sensitivity screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b854fbb38960300dad4f02ea896e2c
https://doi.org/10.1158/0008-5472.22399764.v1
https://doi.org/10.1158/0008-5472.22399764.v1
Publikováno v:
Nature structural & molecular biology
Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. 5-hydroxymethylcytosine binding, embryonic stem cell-specific protein (HMCES) recognizes and processes these lesions in the context of single-stranded DNA (s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49e07a450c0b051c45d0d40b011aeff
https://doi.org/10.1038/s41594-019-0255-5
https://doi.org/10.1038/s41594-019-0255-5
Autor:
David Cortez, Kareem N. Mohni, Kamakoti P. Bhat, Frank B. Couch, Kristie L. Rose, Huzefa Dungrawala, Gloria G. Glick
Publikováno v:
Molecular Cell. 59:998-1010
The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd506c24710ba29865e6e01c73c92cff
https://doi.org/10.1016/j.molcel.2015.07.030
https://doi.org/10.1016/j.molcel.2015.07.030
Autor:
Manuel Ascano, M. Shane Hutson, Runxiang Zhao, Kareem N. Mohni, David Cortez, Monica E. Lacy, Gina Kavanaugh, Yan Guo, Gloria G. Glick
Publikováno v:
Molecular and Cellular Biology. 35:2979-2990
Accurate replication of DNA is imperative for the maintenance of genomic integrity. We identified Enhancer of Rudimentary Homolog (ERH) using a whole-genome RNA interference (RNAi) screen to discover novel proteins that function in the replication st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084d792239f4e46f5653535e7132af7d
https://doi.org/10.1128/mcb.01276-14
https://doi.org/10.1128/mcb.01276-14
Publikováno v:
Cancer Research. 74:2835-2845
The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions, with deficiencies in the DNA damage response enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2065af8783bd0596ffcb2a647455e37
https://doi.org/10.1158/0008-5472.can-13-3229
https://doi.org/10.1158/0008-5472.can-13-3229
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3497-3509.e4 (2019)
Cell Reports, Vol 28, Iss 13, Pp 3497-3509.e4 (2019)
SUMMARY Identifying proteins that function at replication forks is essential to understanding DNA replication, chromatin assembly, and replication-coupled DNA repair mechanisms. Combining quantitative mass spectrometry in multiple cell types with str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d48d8ee159217bb8fcb192196032f5e
https://doi.org/10.1016/j.celrep.2019.08.051
https://doi.org/10.1016/j.celrep.2019.08.051
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a205-a205
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdf87c1b5f4d0afc31ecfe26d9d026f
https://doi.org/10.1107/s0108767319097988
https://doi.org/10.1107/s0108767319097988