Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kareem Clarke"'
In Vivo Generation of Oligoclonal Colitic CD4+ T-Cell Lines Expressing a Distinct T-Cell Receptor Vβ
Autor:
Cox Terhorst, Kareem Clarke, William A. Faubion, Ana C. Abadía-Molina, Atul K. Bhan, Martina Comiskey, Atsushi Mizoguchi, Svend T. Rietdijk, Ype P. de Jong
Publikováno v:
Gastroenterology. 128:1268-1277
Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM--tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by
Autor:
Charles A. Gullo PhD, Cox Terhorst, Kareem Clarke, Stephen Manning, Hongbin Ji, Duncan Howie, Anthony J. Coyle, Susumu Okamoto
Publikováno v:
European Journal of Immunology. 34:3176-3186
The SH2D1A gene, which is altered or deleted in patients with X-linked lymphoproliferative disease, encodes the small protein SAP (for SLAM-associated protein) that is expressed in T and NK cells. A 22-bp fragment in close proximity to an initiator-l
Autor:
William A. Faubion, Arlene H. Sharpe, Stefan Feske, Charles A. Gullo PhD, Cox Terhorst, Miriam Rodriguez Sosa, Duncan Howie, Abhay R. Satoskar, Kareem Clarke, Susumu Okamoto, Ninghai Wang
Publikováno v:
The Journal of Experimental Medicine
Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus.
Autor:
Jose Carlos Gutierrez-Ramos, Tracy Delaney, Emiko Mizoguchi, William A. Faubion, Stephen Manning, Svend Rietdijk, Atul K. Bhan, Anthony J. Coyle, Cox Terhorst, Ype P. de Jong, Ana C. Abadía-Molina, Kareem Clarke, Jane Tian
Publikováno v:
International Immunology. 16:205-213
Several autoimmune disease models depend on an imbalance in the activation of aggressor T(h)1 and CD4(+)CD25(+) regulatory T (T(reg)) cells. Here we compare the requirement for signals through the co-stimulatory molecules CD28 and inducible co-stimul
Autor:
Stephen J. Simpson, Emiko Mizoguchi, Baoping Wang, Hongbin Ji, William A. Faubion, Ana C. Abadía–Molina, Kareem Clarke, Atul K. Bhan, Cox Terhorst, Ype P. de Jong
Publikováno v:
Gastroenterology. 126(7)
Background & Aims: Syngeneic bone marrow transplantation into the adult tge26 mouse results in severe wasting disease and colitis. On transplantation, the rudimentary thymus of the adult tge26 mouse repopulates briefly but quickly regresses in tempor
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production
Autor:
Susumo Okamoto, Ninghai Wang, Anthony J. Coyle, Stephen Manning, Vijay K. Kuchroo, Joost P. Bruggeman, Edward A. Greenfield, Duncan Howie, Kareem Clarke, Svend T. Rietdijk, Charles A. Gullo PhD, Cox Terhorst
Publikováno v:
Blood. 100(8)
CD150 (signaling lymphocyte activation molecule [SLAM]) is a self-ligand cell surface glycoprotein expressed on T cells, B cells, macrophages, and dendritic cells. To further explore the role of CD150 signaling in costimulation and T(H)1 priming we h
Autor:
Pierre Michetti, Svend Rietdijk, Cox Terhorst, Christine N. Metz, T. Ten Hove, S. J. H. Van Deventer, Jodi B. Lubetsky, M. A. Sahli, Emiko Mizoguchi, William A. Faubion, Mazen Alsahli, Elias Lolis, Atul K. Bhan, Kareem Clarke, John R. David, Abhay R. Satoskar, Ana C. Abadía-Molina, Y.P. de Jong, Richard J. Farrell, Andrew C. Keates
Publikováno v:
Nature immunology, 2(11), 1061-1066. Nature Publishing Group
The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay between the mucosal immune system and intestinal bacteria, we invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a603c620b8f6d83a594f575f1b8aed
https://pure.amc.nl/en/publications/development-of-chronic-colitis-is-dependent-on-the-cytokine-mif(4d49aa82-70ab-499b-b3ed-7235ce0aabf3).html
https://pure.amc.nl/en/publications/development-of-chronic-colitis-is-dependent-on-the-cytokine-mif(4d49aa82-70ab-499b-b3ed-7235ce0aabf3).html
Autor:
Dylan Conklin, Weiping Jia, Arun D. Singh, Richard S. Finn, Judy Dering, Dennis J. Slamon, Kareem Clarke, Yuqiao Shen, Bartosz Chmielowski, Leonard Post, Neil A. O'Brien
Publikováno v:
Cancer Research. 73:3453-3453
Background: A principal function of Poly-ADP-Ribose Polymerase (PARP) proteins is to help orchestrate the DNA damage response by recruiting a multitude of proteins to sites of DNA damage. PARP inhibitors have shown particular promise in settings wher
Autor:
Cox Terhorst, Ype P. de Jong, Kareem Clarke, Ana Clara Abadía-Molina, Hongbin Ji, William A. Faubion
Publikováno v:
Gastroenterology. 124:A60
Autor:
Cox Terhorst, Ype P. de Jong, Christopher Fraser, Anthony J. Coyle, Jose-Carlos Gutierrez-Ramos, Kareem Clarke, Svend T. Rietdijk
Publikováno v:
Gastroenterology. 120:A38