Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Kareem Azab"'
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/3d33aa4280c444ba8044bba083223d23
Autor:
Odai Darawshi, Barbara Muz, Shiri Gershon Naamat, Bellam Praveen, Mohamed Mahameed, Karin Goldberg, Priya Dipta, Miriam Shmuel, Francesca Forno, Shatha Boukeileh, Hadas Pahima, Julia Hermann, Marc S. Raab, Alexandra M. Poos, Niels Weinhold, Chaggai Rosenbluh, Moshe E. Gatt, Wilhelm Palm, Abdel Kareem Azab, Boaz Tirosh
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-12 (2022)
Abstract Multiple myeloma (MM) causes approximately 20% of deaths from blood cancers. Notwithstanding significant therapeutic progress, such as with proteasome inhibitors (PIs), MM remains incurable due to the development of resistance. mTORC1 is a k
Externí odkaz:
https://doaj.org/article/bd25967df6ec4e2f9bb9642f5cf33ff7
Autor:
Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, Abigail E. Case, Wei Ni, Swati Garg, Martin Sattler, Abdel Kareem Azab, Jennifer Sun, Barbara Muz, Dana Sanchez, Anthia Toure, Richard M. Stone, Ilene Galinsky, Eric Winer, Scott Gleim, Sofia Gkountela, Alexia Kedves, Edmund Harrington, Tinya Abrams, Thomas Zoller, Andrea Vaupel, Paul Manley, Michael Faller, BoYee Chung, Xin Chen, Philipp Busenhart, Christine Stephan, Keith Calkins, Debora Bonenfant, Claudio R. Thoma, William Forrester, James D. Griffin
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-10 (2022)
Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule
Externí odkaz:
https://doaj.org/article/3c275c0fed054a4ca5adaa6cd08da2ce
Autor:
Kinan Alhallak, Amanda Jeske, Pilar de la Puente, Jennifer Sun, Mark Fiala, Feda Azab, Barbara Muz, Ilyas Sahin, Ravi Vij, John F. DiPersio, Abdel Kareem Azab
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Cancer patients undergo detrimental toxicities and ineffective treatments especially in the relapsed setting, due to failed treatment attempts. The development of a tool that predicts the clinical response of individual patients to therapy i
Externí odkaz:
https://doaj.org/article/d949d57f50c147fba308ccbe7e50a877
Autor:
Cinzia Federico, Kinan Alhallak, Jennifer Sun, Kathleen Duncan, Feda Azab, Gail P. Sudlow, Pilar de la Puente, Barbara Muz, Vaishali Kapoor, Luna Zhang, Fangzheng Yuan, Matea Markovic, Joseph Kotsybar, Katherine Wasden, Nicole Guenthner, Shannon Gurley, Justin King, Daniel Kohnen, Noha N. Salama, Dinesh Thotala, Dennis E. Hallahan, Ravi Vij, John F. DiPersio, Samuel Achilefu, Abdel Kareem Azab
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-age
Externí odkaz:
https://doaj.org/article/ec116aa5de4e46b1b6f2162c28d0c689
Autor:
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/72bd99275a284a2faf3865116dcc4f48
Publikováno v:
Leukemia Research Reports, Vol 16, Iss , Pp 100268- (2021)
CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the “don't-eat-me” signal. However, accumulating evidence shows that solid and hemat
Externí odkaz:
https://doaj.org/article/70e540e717574752be375e74aea525ef
Autor:
Sarah A. Holstein, Fotis Asimakopoulos, Abdel Kareem Azab, Giada Bianchi, Manisha Bhutani, Leslie A. Crews, Tom Cupedo, Hannah Giles, Sarah Gooding, Jens Hillengass, Lukas John, Shari Kaiser, Lydia Lee, Kylee Maclachlan, Marcelo C. Pasquini, Flavia Pichiorri, Nina Shah, Monica Shokeen, Brian R. Shy, Eric L. Smith, Raluca Verona, Saad Z. Usmani, Philip L. McCarthy
Publikováno v:
Transplantation and Cellular Therapy, 28(8), 446-454. Elsevier Inc.
The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup conducted a workshop on Immune and Cellular Therapy in Multiple Myeloma on January 7, 2022. This workshop included presentations by basic, translational, and clinica
Publikováno v:
Translational Oncology, Vol 10, Iss 4, Pp 632-640 (2017)
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor acti
Externí odkaz:
https://doaj.org/article/4e079c28ef4e49519e919ab09bab7791
Autor:
Barbara Muz, Maurizio Buggio, Feda Azab, Pilar de la Puente, Mark Fiala, Mahesh V. Padval, David T. Weaver, Jonathan A. Pachter, Ravi Vij, Abdel Kareem Azab
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Externí odkaz:
https://doaj.org/article/55f3826128f14bdb90b8b4dcda945deb