Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Karch CM"'
Publikováno v:
Clinical Interventions in Aging, Vol Volume 14, Pp 73-79 (2018)
Justina P Tavana,1,* Matthew Rosene,2,* Nick O Jensen,2 Perry G Ridge,1 John SK Kauwe,1,3 Celeste M Karch2,4 1Department of Biology, Brigham Young University, Provo, UT 84602, USA; 2Department of Psychiatry, Washington University in St Louis, St Loui
Externí odkaz:
https://doaj.org/article/eb7048d406034231a0061c376e346c0a
Autor:
Bowles, KR, Pugh, DA, Farrell, K, Han, N, TCW, J, Liu, Y, Liang, SA, Qian, L, Bendl, J, Fullard, JF, Renton, AE, Casella, A, Iida, MA, Bandres-Ciga, S, Gan-Or, Z, Heutink, P, Siitonen, A, Bertelsen, S, Karch, CM, Frucht, SJ, Kopell, BH, Peter, I, Park, YJ, Crane, PK, Kauwe, JSK, Boehme, KL, Höglinger, GU, Charney, A, Roussos, P, Wang, JC, Poon, WW, Raj, T, Crary, JF, Goate, AM
Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) are clinically similar neurodegenerative movement disorders that display unique neuropathological features (i.e. Lewy body pathology and Tau pathology, respectively). While each diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::2d6706e6d97f237d2d7028adee6d4ff1
Autor:
Suarez-Calvet, M, Morenas-Rodriguez, E, Kleinberger, G, Schlepckow, K, Caballero, MAA, Franzmeier, N, Capell, A, Fellerer, K, Nuscher, B, Eren, E, Levin, J, Deming, Y, Piccio, L, Karch, CM, Cruchaga, C, Shaw, LM, Trojanowski, JQ, Weiner, M, Ewers, M, Haass, C, Alzheimers Dis Neuroimaging
Publikováno v:
Molecular Neurodegeneration
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
BackgroundTREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). Soluble TREM2 (sTREM2) resulting from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8cad209e182c55aad6c082f454920ca6
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3048
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3048
Autor:
Bonham, LW, Steele, NZR, Karch, CM, Manzoni, C, Geier, EG, Wen, N, Ofori-Kuragu, A, Momeni, P, Hardy, J, Miller, ZA, Hess, CP, Lewis, P, Miller, BL, Seeley, WW, Baranzini, SE, Desikan, RS, Ferrari, R, Yokoyama, JS, International FTD-Genomics Consortium IFGC
Publikováno v:
Neurology. Genetics, vol 4, iss 5
Bonham, LW; Steele, NZR; Karch, CM; Manzoni, C; Geier, EG; Wen, N; et al.(2018). Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.. Neurology. Genetics, 4(5), e266. doi: 10.1212/NXG.0000000000000266. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9mn3k1r0
Bonham, LW; Steele, NZR; Karch, CM; Manzoni, C; Geier, EG; Wen, N; et al.(2018). Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.. Neurology. Genetics, 4(5), e266. doi: 10.1212/NXG.0000000000000266. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9mn3k1r0
Objective:The neuroanatomical profile of behavioral variant frontotemporal dementia (bvFTD) suggests a common biological etiology of disease despite disparate pathologic causes; we investigated the genetic underpinnings of this selective regional vul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1c1cf144d02cdc24513a548306cae63b
https://escholarship.org/uc/item/9mn3k1r0
https://escholarship.org/uc/item/9mn3k1r0
Autor:
Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genomics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS, Collaborators: Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JBJ, Dobson-Stone C, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernández I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Albani D, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimón J, Lleó A, Blesa R, Landqvist Waldö M, Nilsson C, Mackenzie IRA, Hsiung GYR, Mann DMA, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JCM, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Cruts M, Van Broeckhoven C, Cappa SF, Leber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YAL, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebouvier T, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Momeni P.
Publikováno v:
Journal of Neurology, Neurosurgery and Psychiatry, 88(2), 152-164. BMJ Publishing Group
Journal of neurology, neurosurgery and psychiatry
The IFGC and IPDGC members 2017, ' Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 2, pp. 152-164 . https://doi.org/10.1136/jnnp-2016-314411
Journal of neurology, neurosurgery and psychiatry
The IFGC and IPDGC members 2017, ' Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 2, pp. 152-164 . https://doi.org/10.1136/jnnp-2016-314411
Background Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer9s disease (AD) and Parkinson9s disease (PD) has been suggested; however, the relationship between these disorders is still not well unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de072e936d260a1800fa6d632d00a31
https://europepmc.org/articles/PMC5237405/
https://europepmc.org/articles/PMC5237405/
Autor:
Karch, CM, Wen, N, Fan, CC, Yokoyama, JS, Kouri, N, Ross, OA, Hoeglinger, G, Mueller, U, Ferrari, R, Hardy, J, Schellenberg, GD, Sleiman, PM, Momeni, P, Hess, CP, Miller, BL, Sharma, M, Van Deerlin, V, Smeland, OB, Andreassen, OA, Dale, AM, Desikan, RS, FTD, IFD, Frontotemporal, IC, PS, PSP, Co, IPDG
Publikováno v:
Karch, CM; Wen, N; Fan, CC; Yokoyama, JS; Kouri, N; Ross, OA; et al.(2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY, 75(7), 860-875. doi: 10.1001/jamaneurol.2018.0372. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/01r1k8tv
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by loss of upper and lower motor neurons. Although novel ALS genetic variants have been identified, the shared genetic risk between ALS and other neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0220f7981706e71ac019ccb3d29b6755
http://www.escholarship.org/uc/item/01r1k8tv
http://www.escholarship.org/uc/item/01r1k8tv
Autor:
Bonham, LW, Karch, CM, Fan, CC, Tan, C, Geier, EG, Wang, Y, Wen, N, Broce, IJ, Li, Y, Barkovich, MJ, Ferrari, R, Hardy, J, Momeni, P, Höglinger, G, Müller, U, Hess, CP, Sugrue, LP, Dillon, WP, Schellenberg, GD, Miller, BL, Andreassen, OA, Dale, AM, Barkovich, AJ, Yokoyama, JS, Desikan, RS, Hernandez, DG, Nalls, MA, Rohrer, JD, Ramasamy, A, Kwok, JBJ, Dobson-Stone, C, Schofield, PR, Halliday, GM, Hodges, JR, Piguet, O, Bartley, L, Thompson, E, Haan, E, Hernández, I, Ruiz, A, Boada, M, Borroni, B, Padovani, A, Cruchaga, C, Cairns, NJ, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimón, J, Lleó, A, Blesa, R, Waldö, ML, Nilsson, K, Nilsson, C, MacKenzie, IRA, Hsiung, GYR, Mann, DMA, Grafman, J, Morris, CM, Attems, J, Griffiths, TD, McKeith, IG, Thomas, AJ, Pietrini, P, Huey, ED, Wassermann, EM, Baborie, A, Jaros, E, Tierney, MC, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, George-Hyslop, PS, Rossi, G, Tagliavini, F, Giaccone, G, Rowe, JB, Schlachetzki, JCM, Uphill, J, Collinge, J, Mead, S, Danek, A, Van Deerlin, VM
Publikováno v:
Bonham, LW; Karch, CM; Fan, CC; Tan, C; Geier, EG; Wang, Y; et al.(2018). CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry, 8(1). doi: 10.1038/s41398-017-0049-7. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3br131m2
© 2017 The Author(s). Neurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d3091c3a1c07d4f5f93b94dc0537ea
Autor:
Tan, CH, Fan, CC, Mormino, EC, Sugrue, LP, Broce, IJ, Hess, CP, Dillon, WP, Bonham, LW, Yokoyama, JS, Karch, CM, Brewer, JB, Rabinovici, GD, Miller, BL, Schellenberg, GD, Kauppi, K, Feldman, HA, Holland, D, McEvoy, LK, Hyman, BT, Bennett, DA, Andreassen, OA, Dale, AM, Desikan, RS
Publikováno v:
Tan, CH; Fan, CC; Mormino, EC; Sugrue, LP; Broce, IJ; Hess, CP; et al.(2018). Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition. Acta Neuropathologica, 135(1), 85-93. doi: 10.1007/s00401-017-1789-4. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0s35n5pj
© 2017, Springer-Verlag GmbH Germany, part of Springer Nature. There is an urgent need for identifying nondemented individuals at the highest risk of progressing to Alzheimer’s disease (AD) dementia. Here, we evaluated whether a recently validated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::3c23385d4e2d60212d58718a18aadd0a
http://www.escholarship.org/uc/item/0s35n5pj
http://www.escholarship.org/uc/item/0s35n5pj
Autor:
Broce, I, Karch, CM, Wen, N, Fan, CC, Wang, YP, Tan, CH, Kouri, N, Ross, OA, Hoglinger, GU, Muller, U, Hardy, J, Momeni, P, Hess, CP, Dillon, WP, Miller, ZA, Bonham, LW, Rabinovici, GD, Rosen, HJ, Schellenberg, GD, Franke, A, Karlsen, TH, Veldink, JH, Ferrari, R, Yokoyama, JS, Miller, BL, Andreassen, OA, Dale, AM, Desikan, RS, Sugrue, LP, Clarimón J., Lleó A., Blesa R., Hardy, John
Publikováno v:
PLOS MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Background Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::374274b8cfa684db2d2a670a0033db6d
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6202
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6202
Autor:
Ferrari, R, Wang, Y, Vandrovcova, J, Guelfi, S, Witeolar, A, Karch, CM, Schork, AJ, Fan, CC, Brewer, JB, Momeni, P, Schellenberg, GD, Dillon, WP, Sugrue, LP, Hess, CP, Yokoyama, JS, Bonham, LW, Rabinovici, GD, Miller, BL, Andreassen, OA, Dale, AM, Hardy, J, Desikan, RS, Hernandez, DG, Nalls, MA, Rohrer, JD, Ramasamy, A, Kwok, JBJ, Dobson-Stone, C, Schofield, PR, Halliday, GM, Hodges, JR, Piguet, O, Bartley, L, Thompson, E, Haan, E, Hernández, I, Ruiz, A, Boada, M, Borroni, B, Padovani, A, Cruchaga, C, Cairns, NJ, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimón, J, Lleó, A, Blesa, R, Landqvist Waldö, M, Nilsson, K, Nilsson, C, Mackenzie, IRA, Hsiung, GYR, Mann, DMA, Grafman, J, Morris, CM, Attems, J, Griffiths, TD, McKeith, IG, Thomas, AJ, Pietrini, P, Huey, ED, Wassermann, EM, Baborie, A, Jaros, E, Tierney, MC, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, St George-Hyslop, P, Rossi, G, Tagliavini, F, Giaccone, G, Rowe, JB, Schlachetzki, JCM, Uphill, J
Publikováno v:
Ferrari, R; Wang, Y; Vandrovcova, J; Guelfi, S; Witeolar, A; Karch, CM; et al.(2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry, 88(2), 152-164. doi: 10.1136/jnnp-2016-314411. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/09r1w13w
© Published by the BMJ Publishing Group Limited. Background Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::086cc7303d093b4706c2268e4963bd64
http://www.escholarship.org/uc/item/09r1w13w
http://www.escholarship.org/uc/item/09r1w13w