Single-microglia transcriptomic transition network-based prediction and real-world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease.

Autor: Xu J; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Song W; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Xu Z; Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, New York, USA., Danziger MM; AI for Accelerated Healthcare and Life Sciences Discovery, IBM Research-Israel, Haifa, Israel., Karavani E; AI for Accelerated Healthcare and Life Sciences Discovery, IBM Research-Israel, Haifa, Israel., Zang C; Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, New York, USA., Chen X; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Li Y; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Paz IMR; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Gohel D; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Su C; Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, New York, USA., Zhou Y; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Hou Y; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Shimoni Y; AI for Accelerated Healthcare and Life Sciences Discovery, IBM Research-Israel, Haifa, Israel., Pieper AA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA.; Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA., Hu J; IBM T.J. Watson Research Center, Yorktown Heights, New York, USA., Wang F; Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, New York, USA., Rosen-Zvi M; AI for Accelerated Healthcare and Life Sciences Discovery, IBM Research-Israel, Haifa, Israel., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA., Cummings J; Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA., Cheng F; Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.

Increasing the survival and efficacy of entomopathogenic nematodes on exposed surfaces by Pickering emulsion formulations offers new venue for foliar pest management.

Autor: Ramakrishnan J; Department of Plant Pathology and Weed Research, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel; Department of Agroecology and Plant Health, The Robert H. Smith Faculty of Agriculture, Food & Environment the Hebrew University of Jerusalem, Rehovot 7610001, Israel., Salame L; Department of Plant Pathology and Weed Research, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel., Mani KA; Department of Food Science, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel; Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel., Feldbaum R; Department of Food Science, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel., Karavani E; Department of Vegetable Research, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel., Mechrez G; Department of Food Science, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel., Glazer I; Department of Entomology, Nematology and Chemistry Units, Agricultural Research Organization, Volcani Institute, Rishon LeZion 7505101, Israel., Ment D; Department of Plant Pathology and Weed Research, Agricultural Research Organization (ARO), Volcani Institute, Rishon LeZion 7505101, Israel. Electronic address: danam@volcani.agri.gov.il.

Publikováno v: Journal of invertebrate pathology [J Invertebr Pathol] 2023 Jul; Vol. 199, pp. 107938. Date of Electronic Publication: 2023 Jun 01.

FairPRS: adjusting for admixed populations in polygenic risk scores using invariant risk minimization.

Autor: Machado Reyes D; Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY, USA., Bose A, Karavani E, Parida L

Publikováno v: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing [Pac Symp Biocomput] 2023; Vol. 28, pp. 198-208.

Pepper Fruit Elongation Is Controlled by Capsicum annuum Ovate Family Protein 20 .

Autor: Borovsky Y; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel., Raz A; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel., Doron-Faigenboim A; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel., Zemach H; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel., Karavani E; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel., Paran I; Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel.

Publikováno v: Frontiers in plant science [Front Plant Sci] 2022 Jan 04; Vol. 12, pp. 815589. Date of Electronic Publication: 2022 Jan 04 (Print Publication: 2021).

RW3 FRAMEWORK FOR RELIABLE VALUE ASSESSMENT OF TREATMENTS USING CAUSAL ANALYSIS OF OBSERVATIONAL DATA: SUPPORT MATCHING BIOLOGICAL THERAPY TO RHEUMATOID ARTHRITIS PATIENTS

Autor: Shimoni, Y., Ravid, S., Bak, P., Karavani, E., Hensley Alford, S., Meade, D., Goldschmidt, Y.

Publikováno v: In Value in Health May 2019 22 Supplement 2:S389-S389