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Akademický článek

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Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels

Autor: Cardozo, B. Karatza, E. Karalis, V.

Summary: To develop a population pharmacokinetic model that describes the absorption and low plasma levels of risedronate in the body. The impact of patients’ characteristics on risedronate kinetics is investigated. Simulations revealed the high va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a1f5b6ecf5f7835507661919ca6130a4
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3119244

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Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens

Autor: Karatza, E. Ismailos, G. Karalis, V.

Colchicine is widely investigated for cardioprotection of COVID-19 patients since it can prevent the phenomenon of ‘cytokine storm’ and may reduce the complications arising from COVID-19. Despite the potentially beneficial effects of colchicine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::8db830603fdf51efdcd89f4ca127ac3c
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020527

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Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations

Autor: Karatza, E. Ismailos, G. Marangos, M. Karalis, V.

During the recent COVID-19 outbreak hydroxychloroquine (HCQ) has been proposed as a safe and effective therapeutic option. However, a wide variety of dosing schemes has been applied in the clinical practice and tested in clinical studies. An extended

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::8c942e3591f5607a71eb1d7d12f261d2
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020590

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Investigating the Impact of Gastric Emptying on Pharmacokinetic Parameters Using Delay Differential Equations and Principal Component Analysis

Autor: Karatza, E. Karalis, V.

Background and Objectives: Losartan presents multiple peaks after single oral administration, which can be attributed to gastric emptying. The aim of this study was to describe the multiple peak phenomenon of losartan using a delay differential model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::ffd39c4e8540e127ea960e3f5f0e07d8
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020342

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Chloroquine dosage regimens in patients with COVID-19: Safety risks and optimization using simulations

Autor: Karalis, V. Ismailos, G. Karatza, E.

Currently no specific medicinal treatment exists against the new SARS-CoV2 and chloroquine is widely used, since it can decrease the length of hospital stay and improve the evolution of the associated COVID-19 pneumonia. However, several safety conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::d99ed5e59557330aeb6ef0595f447701
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3035151

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