Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia.

Autor: Karatza E; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Janssen Research & Development, LLC, Spring House, PA, USA., Sinha J; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Maglalang PD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Edginton A; School of Pharmacy, University of Waterloo, Kitchener, ON, Canada., Gonzalez D; Division of Clinical Pharmacology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA. daniel.gonzalez@duke.edu.; Duke Clinical Research Institute, PO Box 17969, Durham, NC, 27715, USA. daniel.gonzalez@duke.edu.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Oct; Vol. 63 (10), pp. 1435-1448. Date of Electronic Publication: 2024 Sep 19.

Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways.

Autor: Veroutis D; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Argyropoulou OD; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Goules AV; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Research Institute for Systemic Autoimmune Diseases, Athens, Greece.; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Kambas K; Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece., Palamidas DA; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Research Institute for Systemic Autoimmune Diseases, Athens, Greece., Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Havaki S; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Valakos D; Center of Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Xingi E; Light Microscopy Unit, Hellenic Pasteur Institute, Athens, Greece., Karatza E; Second Propaedeutic Department of Surgery, Laikon General Hospital, Athens, Greece., Boki KA; Rheumatology Unit, Sismanoglion Hospital, Athens, Greece., Cavazza A; Unit of Pathology, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy., Kittas C; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Thanos D; Center of Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Ricordi C; Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, and University of Modena, Reggio Emilia, Italy.; Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy., Marvisi C; Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, and University of Modena, Reggio Emilia, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy., Muratore F; Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, and University of Modena, Reggio Emilia, Italy.; Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy., Galli E; Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, and University of Modena, Reggio Emilia, Italy.; Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy., Croci S; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Salvarani C; Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, and University of Modena, Reggio Emilia, Italy agtzi@med.uoa.gr vgorg@med.uoa.gr carlo.salvarani@ausl.re.it.; Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy., Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece agtzi@med.uoa.gr vgorg@med.uoa.gr carlo.salvarani@ausl.re.it.; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Tzioufas AG; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece agtzi@med.uoa.gr vgorg@med.uoa.gr carlo.salvarani@ausl.re.it.; Research Institute for Systemic Autoimmune Diseases, Athens, Greece.; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Center of stratified medicine in autoimmune and rheumatic diseases, Biomedical Research Foundation Academy of Athens, Athens, Greece.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2024 Feb 15; Vol. 83 (3), pp. 342-350. Date of Electronic Publication: 2024 Feb 15.

Editorial: Advanced approaches in pediatric clinical pharmacology.

Autor: Al-Sallami H; School of Pharmacy, University of Otago, Dunedin, New Zealand., Diniz A; Laboratory of Pharmacokinetics and Biopharmacy, Department of Phamacy, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Sinha J; Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Karatza E; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Allegaert K; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.; Department of Hospital Pharmacy, Erasmus MC, Rotterdam, Netherlands.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jan 30; Vol. 15, pp. 1372290. Date of Electronic Publication: 2024 Jan 30 (Print Publication: 2024).

Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels

Autor: Cardozo, B. Karatza, E. Karalis, V.

Summary: To develop a population pharmacokinetic model that describes the absorption and low plasma levels of risedronate in the body. The impact of patients’ characteristics on risedronate kinetics is investigated. Simulations revealed the high va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a1f5b6ecf5f7835507661919ca6130a4
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3119244

Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens

Autor: Karatza, E. Ismailos, G. Karalis, V.

Colchicine is widely investigated for cardioprotection of COVID-19 patients since it can prevent the phenomenon of ‘cytokine storm’ and may reduce the complications arising from COVID-19. Despite the potentially beneficial effects of colchicine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::8db830603fdf51efdcd89f4ca127ac3c
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020527