Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karanjawala, Rushad"'
Autor:
Kochanny, Monica J., Adler, Marc, Ewing, Janice, Griedel, Brian D., Ho, Elena, Karanjawala, Rushad, Lee, Wheeseong, Lentz, Dao, Liang, Amy M., Morrissey, Michael M., Phillips, Gary B., Post, Joseph, Sacchi, Karna L., Sakata, Steven T., Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Whitlow, Marc, Ye, Bin, Zhao, Zuchun, Shaw, Kenneth J.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2007 15(5):2127-2146
Autor:
Dao Lentz, Marc Whitlow, Kenneth J. Shaw, Karna Lyn Sacchi, Sakata Steven T, Janette Walters, Kathy White, Joseph Post, Bin Ye, Wheeseong Lee, Kochanny Monica, Elena Ho, Amy Liang, Ron Vergona, Janice Ewing, Morrissey Michael M, Karanjawala Rushad E, Gary Phillips, Zuchun Zhao, Brian D. Griedel, Babu Subramanyam, Marc Adler
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2127-2146
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b4b05420f1f0b4641803f66b53494f
https://doi.org/10.1016/j.bmc.2006.12.019
https://doi.org/10.1016/j.bmc.2006.12.019
Autor:
Yuo-Ling Chou, John Morser, Marc Adler, Wheeseong Lee, Joseph Post, David R. Light, Kochanny Monica, Karna Lyn Sacchi, Dao Lentz, Arnaiz Damian O, Marc Whitlow, Bin Ye, Amy Liang, Ron Vergona, Richard W. Fitch, Mark E. Sullivan, Sarah Cheeseman, Janice Ewing, Zuchun Zhao, Babu Subramanyam, Kathy White, Kenneth J. Shaw, Karanjawala Rushad E, Janette Walters, Brian D. Griedel, Yi-Xin Wang, William P. Dole, Michael M. Morrissey, Steven T. Sakata, Galina Rumennik, Shung C. Wu
Publikováno v:
Journal of medicinal chemistry. 50(13)
There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the coagulation cascade, is among the more promising targets for anticoagulant therapy and has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9b314570fda62e22e2ae9d385e5ac9
https://pubmed.ncbi.nlm.nih.gov/17536795
https://pubmed.ncbi.nlm.nih.gov/17536795
Autor:
Brian D. Griedel, Keith Eagen, Shung C. Wu, Morrissey Michael M, Yuo-Ling Chou, Karna Lyn Sacchi, Lan Trinh, David D. Davey, Kenneth J. Shaw, Karanjawala Rushad E, Dao Lentz, Kochanny Monica, Amy Liang, Gary Phillips
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(3)
Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac456c84cdeb71df61707321081b28
https://pubmed.ncbi.nlm.nih.gov/12565961
https://pubmed.ncbi.nlm.nih.gov/12565961
Akademický článek
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Autor:
Ye, Bin, Chou, Yuo-Ling, Karanjawala, Rushad, Lee, Wheeseong, Lu, Shou-Fu, Shaw, Kenneth J., Jones, Steven, Lentz, Dao, Liang, Amy, Tseng, Jih-Lie, Wu, Qingyu, Zhao, Zuchun
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2004 14(3):761-765
Autor:
Chou, Yuo-Ling, Davey, David D, Eagen, Keith A, Griedel, Brian D, Karanjawala, Rushad, Phillips, Gary B, Sacchi, Karna L, Shaw, Kenneth J, Wu, Shung C, Lentz, Dao, Liang, Amy M, Trinh, Lan, Morrissey, Michael M, Kochanny, Monica J
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2003 13(3):507-511