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Akademický článek
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Objectives: Toll-like receptors (TLRs) may promote or inhibit tumor progression. The aim of this study was to assess the expression of TLR4 and TLR9 and their downstream targets in oral tongue squamous cell carcinoma (OTSCC) in correlation with histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::c87108f530ee504ef1a5d0b04b034567
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2989995
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2989995
Publikováno v:
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
instname
Signal transducer and activator of transcription 3 (STAT3) and mitogen activated protein kinases (MAPKs), including ERK and JNK, have been implicated in oral squamous cell carcinoma (OSCC) development and progression. Our purpose was to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::ce8762fe8e9b2e98b4172b949ae8d064
http://hdl.handle.net/10201/117747
http://hdl.handle.net/10201/117747
Signal transducer and activator of transcription 3 (STAT3) and mitogen activated protein kinases (MAPKs), including ERK and JNK, have been implicated in oral squamous cell carcinoma (OSCC) development and progression. Our purpose was to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::234d09b8e8122b1dbb998592f84e10ed
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3126567
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3126567
The present study aims to investigate the expression levels of two critical mammalian target of rapamycin (mTOR) downstream effectors, 4E binding protein 1 (4EBP1) and eukaryotic initiation factor 4E (eIF4E) proteins, in precancerous squamous intraep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::0eccfb237aebccc708b1148d3bd2a8e3
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3086416
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3086416
Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that link extracellular stimuli with intracellular responses and participate in numerous cellular processes such as growth, proliferation, differentiation, inflammation and apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::bc108cc61c0f14c55d3c876b5a4f3071
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3085982
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3085982
Background. Mammalian target of rapamycin (mTOR) forms 2 active complexes in the cell: the rapamycinsensitive mTOR-Raptor (mTORC1) and the rapamycin-insensitive mTOR-Rictor (mTORC2). The latter activates AKT kinase, which promotes tumor cell survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::40a68989cdaab80f0f67414ee76fd390
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3127068
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3127068
Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway possesses confirmed oncogenic potential in oral squamous cell carcinoma (OSCC). Crosstalk with other molecular pathways contributes to STAT3 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::dca9e212e3deb4e29f4ee3f6bd7c14f3
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3087954
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3087954
c-JUN N-terminal Kinase (JNK) is activated/phosphorylated by upstream MAPK kinases (MKK), and, in turn, phosphorylates and activates its major substrate c-JUN, a member of the activator protein-1 (AP-1) transcription factors. c-JUN is overexpressed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::ed02988d74d8935048ad9ef6d4acec3d
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3126939
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3126939
Akademický článek
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