Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Karan R Chadda"'
Autor:
Mengye Li, Karan R Chadda, Gareth D K Matthews, Celia M Marr, Christopher L-H Huang, Kamalan Jeevaratnam
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194008 (2018)
Exercising horses uniquely accommodate 7-8-fold increases in heart rate (HR). The present experiments for the first time analysed the related adaptations in action potential (AP) restitution properties recorded by in vivo telemetric electrocardiograp
Externí odkaz:
https://doaj.org/article/a8c53d4f45624afe8ad5b684cf7432b9
Autor:
Charlotte E. Edling, Ibrahim T. Fazmin, Karan R. Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L.-H. Huang, Kamalan Jeevaratnam
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
BackgroundDeficiencies in the transcriptional co-activator, peroxisome proliferative activated receptor, gamma, coactivator-1β are implicated in deficient mitochondrial function. The latter accompanies clinical conditions including aging, physical i
Externí odkaz:
https://doaj.org/article/ea38010eb3784384b37ba93be7a8742e
Autor:
Philippa Rees, Caitriona Callan, Karan R. Chadda, Meriel Vaal, James Diviney, Shahad Sabti, Fergus Harnden, Julian Gardiner, Cheryl Battersby, Chris Gale, Alastair Sutcliffe
Publikováno v:
Pediatrics. 150
CONTEXT Preterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care are continually evolving. OBJECTIVE To systematically review and meta-analyze neurodevelopmental outcomes among preterm infants after intraven
MicroRNAs (miRNAs) are short, non-protein-coding genes that regulate the expression of numerous protein-coding genes. Their expression is dysregulated in cancer, where they may function as oncogenes or tumour suppressor genes. As miRNAs are highly re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c75e7973d7849a7c862225bd923cc6
https://www.repository.cam.ac.uk/handle/1810/341179
https://www.repository.cam.ac.uk/handle/1810/341179
Autor:
Chantay L. Young, Karan R. Chadda, Ursula A. Matulonis, Hang Lee, Susana M. Campos, Antonella M. D'Ascanio, Richard T. Penson, Michael J. Birrer, Panagiotis A. Konstantinopoulos, Carolyn N. Krasner, Neil S. Horowitz
Publikováno v:
Gynecologic Oncology. 162:661-666
Background Topoisomerase-1 inhibitors are an important class of cytotoxics associated with toxicity that limits their use. CRLX101 is a novel cyclodextrin-containing polymer conjugate of camptothecin (CPT) that self-assembles into nanoparticles to de
Autor:
Daniel Scoffings, Jessica C Pickles, Patrick S. Tarpey, Jamie Trotman, Thomas S. Jacques, Karan R Chadda, Sam Behjati, Andrew F. Dean, Kieren Allinson, Matthew J. Murray, Katherine Holland
Publikováno v:
Neuropathology and Applied Neurobiology. 47:882-888
Brain tumours are the commonest childhood neoplasm, with a worldwide incidence of 29.9-47.1/million (1). Childhood brain tumours carry substantial morbidity/mortality and are the largest cause of paediatric cancer deaths (2). Historically, classifica
Autor:
Karan R. Chadda, Charlotte E. Edling, Haseeb Valli, Shiraz Ahmad, Christopher L.-H. Huang, Kamalan Jeevaratnam
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3450 (2018)
Increases in the prevalence of obesity, insulin resistance, and metabolic syndrome has led to the increase of atrial fibrillation (AF) cases in the developed world. These AF risk factors are associated with mitochondrial dysfunction, previously model
Externí odkaz:
https://doaj.org/article/4bc5429cae294398a4482b238d56f157
Publikováno v:
When Things Go Wrong In Urology ISBN: 9783031136573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8e92f4699abc3e266d407806930b5a
https://doi.org/10.1007/978-3-031-13658-0_5
https://doi.org/10.1007/978-3-031-13658-0_5
Autor:
Kamalan Jeevaratnam, N Nanthakumar, Khalil Saadeh, Charlotte E. Edling, C Huang, Shiraz Ahmad, Karan R. Chadda, H Valli, Ibrahim T. Fazmin
Publikováno v:
European Heart Journal. 42
Background The risk of cardiac arrhythmias increases significantly in patients with metabolic disorders such as obesity and diabetes mellitus. The mechanisms linking metabolic conditions and electrophysiological changes underlying cardiac arrhythmias
Autor:
Khalil Saadeh, Shiraz Ahmad, Christopher L.-H. Huang, Nakulan Nanthakumar, Kamalan Jeevaratnam, Charlotte E. Edling, Haseeb Valli, Karan R. Chadda, Ibrahim T. Fazmin
Publikováno v:
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 27, Iss, Pp 100753-(2021)
Molecular Genetics and Metabolism Reports, Vol 27, Iss, Pp 100753-(2021)
Mitochondrial dysfunction underlying metabolic disorders such as obesity and diabetes mellitus is strongly associated with cardiac arrhythmias. Murine Pgc-1α−/− hearts replicate disrupted mitochondrial function and model the associated pro-arrhy