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Phosphoramidate conjugates of 3′-azido-3′-deoxythymidine glycerolipid derivatives and amino acid esters: synthesis and anti-HIV activity

Autor: Andrei E. Siniavin, Elizaveta S. Darnotuk, N. S. Shastina, Nikolay V. Shulga, Karamov Ev

Publikováno v: Medicinal Chemistry Research. 30:664-671

We report the synthesis of phosphoramidate conjugates of 3′-azido-3′-deoxythymidine (AZT) glycerolipid derivatives and amino acid esters. For the synthesized compounds, 50% inhibition of the HIV-1 MvP-899 strain in human T lymphoid MT-4 cells is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a40ff28d9ed50725b871f8c91a8604c
https://doi.org/10.1007/s00044-020-02672-8

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Antiviral activity of natural humic substances and shilajit materials against HIV-1: Relation to structure

Autor: Kornilaeva Gv, Yury Zhernov, Irina V. Perminova, Mikhail I. Savinykh, Andrey I. Konstantinov, Karamov Ev, Eugene N. Nikolaev, Alexey A. Orlov, Alexander Zherebker

Publikováno v: Environmental Research

Natural products, such as humic substances (HS) and shilajit, are known to possess antiviral activity. Humic-like components are often called as carriers of biological activity of shilajit. The goal of this study was to evaluate anti-HIV activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb4abd29d90864a090eb350103ea6e6
https://pubmed.ncbi.nlm.nih.gov/33065073

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HIV-1 Genetic Diversity in Recently Diagnosed Infections in Moscow: Predominance of AFSU, Frequent Branching in Clusters, and Circulation of the Iberian Subtype G Variant

Autor: Khoren Epremyan, Andrei E. Siniavin, Lucía Pérez-Álvarez, Karamov Ev, Mónica Sánchez-Martínez, Ali Turgiev, Michael M. Thomson, Kornilaeva Gv, Cristina Carrera, Joan Bacqué, María Teresa Cuevas, Yury Zhernov, Elena Delgado

Publikováno v: AIDS Research and Human Retroviruses. 34:629-634

HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (AFSU) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb7af85eb3585106ef2b9e37419f8939
https://doi.org/10.1089/aid.2018.0055

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Investigation of Human Immunodeficiency Virus Fusion Peptides. Analysis of Interrelations Between Their Structure and Function

Autor: V.M. Chumakov, V.B. Grigoriev, R.A. Manukyan, A.E. Grinfeldt, V.A. Slepushkin, Karamov Ev, G.B. Melikyan, Maria Sidorova, Andreev Sm

Publikováno v: AIDS Research and Human Retroviruses. 8:9-18

The N-terminal region of the human immunodeficiency virus type 1 (HIV-1) gp41 appears to be involved in virus-cell membrane fusion. To study the influence of fusion domain structure on gp41 interaction with artificial lipid membranes, two families of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d3e28ab6ab79d444e339596fd00e84
https://doi.org/10.1089/aid.1992.8.9

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Enzyme immunoassay system for detecting antibodies in complexes with HIV-1 antigens

Autor: A. V. Abelyan, V. V. Burunova, M. Yu Shchelkanov, Karamov Ev, D. O. Kabdulova

Publikováno v: Scopus-Elsevier

An enzyme immunoassay is proposed for detection of antibodies in complexes with antigens. Specific anti-HIV antibodies were detected in sera which were considered HIV-negative.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34237b1be3ca44d4fc4a191ceba642c8
https://doi.org/10.1007/bf02446917

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CD4-derived peptide and sulfated polysaccharides have similar mechanisms of anti-HIV activity based on electrostatic interactions with positively charged gp120 fragments

Autor: Karamov Ev, Diana Meshcheryakova, Sofia Tarasova, Vafina Mg, Khaitov Rakhim M, Kornilaeva Gv, Maria Sidorova, Andreev Sm

Publikováno v: Molecular immunology. 30(11)

The mechanism of antiviral activity of the CD4-derived peptide 75-99 was compared with that of sulfated polysaccharides. A set of peptides representing all the high positive charge density regions of gp120 and gp41 was used to determine whether elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26f41999c2d9b17a7aa245709f091b
https://pubmed.ncbi.nlm.nih.gov/8102473

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Transformation of substrate specificity of EcoRl restrictase by glycerol

Autor: Tikhonenko Ti, Zavizion Ba, Karamov Ev, B. S. Naroditskii

Publikováno v: Bulletin of Experimental Biology and Medicine. 84:973-975

In the presence of glycerol, EcoRl restriction endonuclease hydrolyzes DNA into a larger number of fragments than under ordinary conditions. On the addition of glycerol to 50% concentration, this enzyme begins to act by what is called the “EcoRl' t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c3d8014e4115a99afc36d9425a31348
https://doi.org/10.1007/bf00798520

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