Spatial Heterogeneity of Immune Regulators Drives Dynamic Changes in Local Immune Responses, Affecting Disease Outcomes in Pancreatic Cancer.

Autor: Karamitopoulou E; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Wenning AS; Department of Visceral Surgery, Insel University Hospital, University of Bern, Bern, Switzerland., Acharjee A; University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom., Aeschbacher P; Department of Visceral Surgery, Insel University Hospital, University of Bern, Bern, Switzerland., Marinoni I; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Zlobec I; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Gloor B; Department of Visceral Surgery, Insel University Hospital, University of Bern, Bern, Switzerland., Perren A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Sep 13; Vol. 30 (18), pp. 4215-4226.

Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.

Autor: Ahmed A; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany.; Department of Pharmacology, Faculty of Medicine, University of Khartoum, Sudan., Reinhold C; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Breunig E; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Phan TS; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Dietrich L; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Kostadinova F; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Urwyler C; Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland., Merk VM; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Noti M; Institute of Pathology, University of Bern, Switzerland., Toja da Silva I; International Research Center, A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology - Oncogenomics and Therapeutic Innovation (INCT-INOTE), São Paulo, Brazil., Bode K; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Nahle F; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Plazzo AP; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany., Koerner J; Division of Immunology, Department of Biology, University of Konstanz, Germany., Stuber R; Institute of Pathology, University of Bern, Switzerland., Menche C; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany., Karamitopoulou E; Institute of Pathology, University of Bern, Switzerland., Farin HF; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany., Gollob KJ; International Research Center, A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology - Oncogenomics and Therapeutic Innovation (INCT-INOTE), São Paulo, Brazil.; Albert Einstein Israelite Hospital, São Paulo, Brazil., Brunner T; Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Germany.

Publikováno v: Molecular oncology [Mol Oncol] 2023 Aug; Vol. 17 (8), pp. 1545-1566. Date of Electronic Publication: 2023 Mar 09.

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Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma.

Autor: Ferguson LP; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Gatchalian J; Salk Institute for Biological Studies, La Jolla, CA, USA., McDermott ML; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Nakamura M; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Chambers K; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Rajbhandari N; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Lytle NK; Salk Institute for Biological Studies, La Jolla, CA, USA., Rosenthal SB; Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine, La Jolla, CA, USA., Hamilton M; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Albini S; Genethon, 91000, EVRY, France.; Université Paris-Saclay, Univ Evry, Inserm, Genethon, Integrare research unit UMR_S951, 91000, Evry, France., Wartenberg M; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Zlobec I; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Galván JA; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Karamitopoulou E; Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Vavinskaya V; Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA, USA., Wascher A; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego School of Medicine, La Jolla, CA, USA., Lowy AM; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego School of Medicine, La Jolla, CA, USA., Schürch CM; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany., Puri PL; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Bruneau BG; Gladstone Institutes, Roddenberry Center for Stem Cell Biology and Medicine, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Hargreaves DC; Salk Institute for Biological Studies, La Jolla, CA, USA. dhargreaves@salk.edu., Reya T; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA. tr2726@cumc.columbia.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA. tr2726@cumc.columbia.edu.; Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA. tr2726@cumc.columbia.edu.; Department of Physiology and Cellular Biophysics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, 10032, USA. tr2726@cumc.columbia.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 18; Vol. 14 (1), pp. 292. Date of Electronic Publication: 2023 Jan 18.

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion.

Autor: Zeng Q; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Opna Bio SA, Biopole, 1066 Epalinges, Lausanne, Switzerland., Saghafinia S; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Opna Bio SA, Biopole, 1066 Epalinges, Lausanne, Switzerland., Chryplewicz A; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland., Fournier N; Swiss Institute of Bioinformatics (SIB), 1015 Lausanne, Switzerland., Christe L; Institute of Pathology, University of Bern, 3008 Bern, Switzerland., Xie YQ; Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland., Guillot J; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland., Yucel S; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland., Li P; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland.; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland., Galván JA; Institute of Pathology, University of Bern, 3008 Bern, Switzerland., Karamitopoulou E; Institute of Pathology, University of Bern, 3008 Bern, Switzerland., Zlobec I; Institute of Pathology, University of Bern, 3008 Bern, Switzerland., Ataca D; Opna Bio SA, Biopole, 1066 Epalinges, Lausanne, Switzerland., Gallean F; Opna Bio SA, Biopole, 1066 Epalinges, Lausanne, Switzerland., Zhang P; Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China., Rodriguez-Calero JA; Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland., Rubin M; Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland., Tichet M; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland.; Lausanne Branch, Ludwig Institute for Cancer Research, 1011 Lausanne, Switzerland., Homicsko K; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland.; Lausanne Branch, Ludwig Institute for Cancer Research, 1011 Lausanne, Switzerland.; Department of Oncology, University Hospital of Lausanne (CHUV), 1011 Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), 1011 Lausanne, Switzerland., Hanahan D; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.; Agora Cancer Research Center, 1011 Lausanne, Switzerland.; Lausanne Branch, Ludwig Institute for Cancer Research, 1011 Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), 1011 Lausanne, Switzerland.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Nov 18; Vol. 378 (6621), pp. eabl7207. Date of Electronic Publication: 2022 Nov 18.