Immune escape of colorectal tumours via local LRH ‐1/Cyp11b1‐mediated synthesis of immunosuppressive glucocorticoids

Autor: Ahmed, Asma, Reinhold, Cindy, Breunig, Eileen, Phan, Truong San, Dietrich, Lea, Kostadinova, Feodora, Urwyler, Corinne, Merk, Verena M, Noti, Mario, Toja da Silva, Israel, Bode, Konstantin, Nahle, Fatima, Plazzo, Anna Pia, Koerner, Julia, Stuber, Regula, Menche, Constantin, Karamitopoulou, Evanthia, Farin, Henner F, Gollob, Kenneth J, Brunner, Thomas

Publikováno v: Molecular Oncology
Ahmed, Asma; Reinhold, Cindy; Breunig, Eileen; Phan, Truong San; Dietrich, Lea; Kostadinova, Feodora; Urwyler, Corinne; Merk, Verena M; Noti, Mario; Toja da Silva, Israel; Bode, Konstantin; Nahle, Fatima; Plazzo, Anna Pia; Koerner, Julia; Stuber, Regula; Menche, Constantin; Karamitopoulou, Evanthia; Farin, Henner F; Gollob, Kenneth J and Brunner, Thomas (2023). Immune escape of colorectal tumors via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. (In Press). Molecular oncology FEBS Press 10.1002/1878-0261.13414

Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f71b6752da83e90fc0607f209efb6f
https://doi.org/10.1002/1878-0261.13414

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Increased tumor-budding/CD8+lymphocytes ratio is associated with metastasis and venous invasion in Pancreatic Ductal Adenocarcinoma (PDAC)

Autor: Karamitopoulou, Evanthia, Zlobec, Inti, Perren, Aurel, Gloor, Beat, Lugli, Alessandro

Publikováno v: Karamitopoulou, Evanthia; Zlobec, Inti; Perren, Aurel; Gloor, Beat; Lugli, Alessandro (2013). Increased tumor-budding/CD8+lymphocytes ratio is associated with metastasis and venous invasion in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), p. 106. Springer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeea8e409172f302fac0f2dbe3546bf
https://boris.unibe.ch/47044/1/Karamitopoulou_Increased_tumor-budding.pdf

TrkB expression in colorectal cancers highlights anoiks-resistance as a possible survival mechanism of tumor budding (EMT-like) cells

Autor: Dawson, Heather, Kölzer, Viktor, Karamitopoulou, Evanthia, Lugli, Alessandro, Zlobec, Inti

Publikováno v: Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). TrkB expression in colorectal cancers highlights anoiks-resistance as a possible survival mechanism of tumor budding (EMT-like) cells. Pathologe, 34(6), pp. 602-603. Springer-Medizin-Verlag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb0efd3be5c0781f89379d3e7d0309

Investigation of IL23 (p19, p40) and IL23R highlights nuclear IL23p19 expression as a marker of indolent tumor features and favorable outcome in colorectal cancer patients

Autor: Zlobec, Inti, Kölzer, Viktor, Dawson, Heather, Langer, Rupert, Karamitopoulou, Evanthia, Lugli, Alessandro

Publikováno v: Zlobec, Inti; Kölzer, Viktor; Dawson, Heather; Langer, Rupert; Karamitopoulou, Evanthia; Lugli, Alessandro (2013). Investigation of IL23 (p19, p40) and IL23R highlights nuclear IL23p19 expression as a marker of indolent tumor features and favorable outcome in colorectal cancer patients. Virchows Archiv, 463(2), pp. 139-140. Springer 10.1007/s00428-013-1444-y

Objective: IL23 is involved in chronic inflammation but its role in cancer progression is not fully elucidated. Here we characterize IL23 subunits p40, p19 and IL23 receptor (IL23R) in the normal-adenoma-carcinomametastasis cascade of colorectal canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59092588d5f7f4dfbe522e62397ce9f2
https://boris.unibe.ch/47049/1/Zlobec_Investigation_of_IL23.pdf