Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karam Aboudehen"'
Autor:
Sachin Hajarnis, Ronak Lakhia, Matanel Yheskel, Darren Williams, Mehran Sorourian, Xueqing Liu, Karam Aboudehen, Shanrong Zhang, Kara Kersjes, Ryan Galasso, Jian Li, Vivek Kaimal, Steven Lockton, Scott Davis, Andrea Flaten, Joshua A. Johnson, William L. Holland, Christine M. Kusminski, Philipp E. Scherer, Peter C. Harris, Marie Trudel, Darren P. Wallace, Peter Igarashi, Edmund C. Lee, John R. Androsavich, Vishal Patel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its i
Externí odkaz:
https://doaj.org/article/5b2531a29caa4303ae532695340657ca
Autor:
Zubaida Saifudeen, Jiao Liu, Susana Dipp, Xiao Yao, Yuwen Li, Nathaniel McLaughlin, Karam Aboudehen, Samir S El-Dahr
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44869 (2012)
Congenital reduction in nephron number (renal hypoplasia) is a predisposing factor for chronic kidney disease and hypertension. Despite identification of specific genes and pathways in nephrogenesis, determinants of final nephron endowment are poorly
Externí odkaz:
https://doaj.org/article/5c50b90e324a4f099cced84c903b7671
Autor:
Laurence Biggers, Thomas L. Carroll, Peter Igarashi, Ronak Lakhia, Harini Ramalingam, Vishal Patel, Silvia Ferrè, Darren P. Wallace, Karam Aboudehen, Matanel Yheskel, Abheepsa Mishra, Andrea Flaten, Christopher P. Chaney
Publikováno v:
JCI Insight
Renal cysts are the defining feature of autosomal dominant polycystic kidney disease (ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of this disorder. Recent studies suggest that immune cells in the cyst micr
Autor:
Chao Xing, Dayeon Lee, Mohammed Kanchwala, Svetlana Avdulov, Peter Igarashi, Shayan Farahani, Micah D. Gearhart, Alan Mickelson, Karam Aboudehen, Vishal Patel, Siu Chiu Chan
Publikováno v:
Journal of Biological Chemistry. 293:9388-9398
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the kidney. ADPKD is primarily caused by mutations in two genes, PKD1 and PKD2. Long noncoding
Autor:
Daniel G. Bichet, Shayan Farahani, Karam Aboudehen, Patricia Cobo-Stark, Lama Noureddine, Peter Igarashi, Micah D. Gearhart, Svetlana Avdulov, Marco Pontoglio, Vishal Patel
Publikováno v:
Journal of the American Society of Nephrology. 28:2887-2900
The transcription factor hepatocyte nuclear factor-1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkhd1
Autor:
John R. Androsavich, Joshua A. Johnson, Andrea Flaten, Matanel Yheskel, William L. Holland, Xueqing Liu, Marie Trudel, Peter Igarashi, Christine M. Kusminski, Mehran Sorourian, Sachin Hajarnis, Edmund C. Lee, Jian Li, Shanrong Zhang, Karam Aboudehen, Darren P. Wallace, Philipp E. Scherer, Steven Lockton, Kara Kersjes, Scott Davis, Peter C. Harris, Vivek Kaimal, Darren Williams, Ronak Lakhia, Vishal Patel, Ryan R. Galasso
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genet
Autor:
Karam Aboudehen
Publikováno v:
Biochim Biophys Acta Gene Regul Mech
The mechanistic target of rapamycin (mTOR) is a major signaling hub that coordinates cellular and organismal responses, such as cell growth, proliferation, apoptosis, and metabolism. Dysregulation of mTOR signaling occurs in many human diseases, and
Autor:
Karam Aboudehen, Ying Zhang, Marco Pontoglio, Svetlana Avdulov, Peter Igarashi, Annie Shao, Jeremy Herrera, Siu Chiu Chan
Background Mutation of HNF1B , the gene encoding transcription factor HNF-1 β , is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414c0dd784d94912f8d1ffac467669d8
https://europepmc.org/articles/PMC6171276/
https://europepmc.org/articles/PMC6171276/
Autor:
Karam, Aboudehen, Shayan, Farahani, Mohammed, Kanchwala, Siu Chiu, Chan, Svetlana, Avdulov, Alan, Mickelson, Dayeon, Lee, Micah D, Gearhart, Vishal, Patel, Chao, Xing, Peter, Igarashi
Publikováno v:
The Journal of biological chemistry. 293(24)
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the kidney. ADPKD is primarily caused by mutations in two genes, PKD1 and PKD2. Long noncoding
Autor:
Susanne Milatz, Nina Himmerkus, Andreas Kompatscher, Karam Aboudehen, René J. M. Bindels, Gertjan C. Veenstra, Shayan Farahani, Lex H. J. van Son, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Publikováno v:
American Journal of Physiology : Renal Physiology, 315, F27-F35
American Journal of Physiology : Renal Physiology, 315, 1, pp. F27-F35
American Journal of Physiology : Renal Physiology, 315, 1, pp. F27-F35
Mutations in hepatocyte nuclear factor 1β (HNF1β) cause autosomal dominant tubulointerstitial kidney disease (ADTKD-HNF1β), and patients tend to develop renal cysts, maturity-onset diabetes of the young (MODY), and suffer from electrolyte disturba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27fdb7ce0054303b1c3ac5cfe5fe5a5
http://hdl.handle.net/2066/194769
http://hdl.handle.net/2066/194769