A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.

Autor: Li R; CAMS Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Colombo M; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Human Technopole, 20157 Milan, Italy., Wang G; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; MRC WIMM Centre for Computational Biology, University of Oxford, Oxford OX3 9DS, UK.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China.; Qizhi Institute, 200232 Shanghai, China., Rodriguez-Romera A; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Benlabiod C; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Jooss NJ; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., O'Sullivan J; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Brierley CK; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Clark SA; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Pérez Sáez JM; Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1420 Buenos Aires, Argentina., Fernández PA; Department of Biotechnology and Biomedicine, Technical University of Denmark Kongens Lyngby 2800, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark Kongens Lyngby 2800, Denmark., Porse B; Finsen Laboratory, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen Denmark.; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark., Meng Y; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Khan AO; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Wen S; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Dong P; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China., Zhou W; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China., Sousos N; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Murphy L; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Clarke M; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Olijnik AA; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Wong ZC; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Karali CS; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Sirinukunwattana K; Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK., Ryou H; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Norfo R; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Interdepartmental Centre for Stem Cells and Regenerative Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy., Cheng Q; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK., Ren Z; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Wuxi School of Medicine, Jiangnan University, Jiangsu 214122, China., Thongjuea S; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Rathinam VA; Department of Immunology, University of Connecticut Health School of Medicine, Farmington, CT 06030, USA., Krishnan A; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Rutgers Cancer Institute of New Jersey and Department of Biomedical Engineering, Rutgers University, New Brunswick, NJ 08901, USA., Royston D; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK., Rabinovich GA; Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1420 Buenos Aires, Argentina.; Facultad de Ciencias Exactas, Físicas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina., Mead AJ; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK., Psaila B; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK.; Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Oct 09; Vol. 16 (768), pp. eadj7552. Date of Electronic Publication: 2024 Oct 09.

Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.

Autor: Khan AO; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom.; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Rodriguez-Romera A; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Reyat JS; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Olijnik AA; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Colombo M; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Wang G; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Wen WX; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Sousos N; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Murphy LC; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Grygielska B; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Perrella G; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Mahony CB; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Ling RE; MRC Weatherall Institute of Molecular Medicine, Department of Paediatrics and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Elliott NE; MRC Weatherall Institute of Molecular Medicine, Department of Paediatrics and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Karali CS; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Stone AP; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts., Kemble S; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Cutler EA; University College London Cancer Institute, London, United Kingdom., Fielding AK; University College London Cancer Institute, London, United Kingdom., Croft AP; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Bassett D; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, United Kingdom., Poologasundarampillai G; School of Dentistry, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom., Roy A; MRC Weatherall Institute of Molecular Medicine, Department of Paediatrics and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Gooding S; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Rayes J; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Machlus KR; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts., Psaila B; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Feb 06; Vol. 13 (2), pp. 364-385.

Impaired antibody response to COVID-19 vaccination in patients with chronic myeloid neoplasms.

Autor: Chowdhury O; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK.; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Bruguier H; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Mallett G; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Sousos N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK.; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Crozier K; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Allman C; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Eyre D; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.; Department of Microbiology, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Lumley S; Department of Microbiology, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Strickland M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK., Karali CS; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK., Murphy L; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK., Sternberg A; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Jeffery K; Department of Microbiology, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Mead AJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK.; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Peniket A; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK., Psaila B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, Oxford, UK.; Department of Haematology, Churchill Hospital, Oxford University Hospitals' NHS Foundation Trust, Oxford, UK.

Publikováno v: British journal of haematology [Br J Haematol] 2021 Sep; Vol. 194 (6), pp. 1010-1015. Date of Electronic Publication: 2021 Jun 24.