Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.

Autor: LeBoeuf SE; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA., Wu WL; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA., Karakousi TR; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA., Karadal B; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA., Jackson SR; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA., Davidson SM; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA., Wong KK; Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA., Koralov SB; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA., Sayin VI; Sahlgrenska Cancer Center, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden., Papagiannakopoulos T; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: papagt01@nyumc.org.

Publikováno v: Cell metabolism [Cell Metab] 2020 Feb 04; Vol. 31 (2), pp. 339-350.e4. Date of Electronic Publication: 2019 Dec 05.

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

Autor: Romero R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Sayin VI; Department of Pathology, New York University School of Medicine, New York, New York, USA., Davidson SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Bauer MR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Singh SX; Department of Pathology, New York University School of Medicine, New York, New York, USA., LeBoeuf SE; Department of Pathology, New York University School of Medicine, New York, New York, USA., Karakousi TR; Department of Pathology, New York University School of Medicine, New York, New York, USA., Ellis DC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Bhutkar A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Sánchez-Rivera FJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Subbaraj L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Martinez B; Department of Pathology, New York University School of Medicine, New York, New York, USA., Bronson RT; Tufts University, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Prigge JR; Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA., Schmidt EE; Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA., Thomas CJ; National Institutes of Health Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, US National Institutes of Health, Bethesda, Maryland, USA., Goparaju C; Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York, USA., Davies A; Champions Oncology, Hackensack, New Jersey, USA., Dolgalev I; Genome Technology Center, New York University School of Medicine, New York, New York, USA., Heguy A; Genome Technology Center, New York University School of Medicine, New York, New York, USA., Allaj V; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Poirier JT; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Moreira AL; Department of Pathology, New York University School of Medicine, New York, New York, USA., Rudin CM; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Pass HI; Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Jacks T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA., Papagiannakopoulos T; Department of Pathology, New York University School of Medicine, New York, New York, USA.; Perlmutter Cancer Center, New York University School of Medicine, New York, New York, USA.

Publikováno v: Nature medicine [Nat Med] 2017 Nov; Vol. 23 (11), pp. 1362-1368. Date of Electronic Publication: 2017 Oct 02.