From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.

Autor: Gordon AC; Division of Anaesthetics, Pain Medicine and Intensive Care and., Alipanah-Lechner N; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California., Bos LD; Intensive Care., Dianti J; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.; Departamento de Cuidados Intensivos, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina., Diaz JV; World Health Organization, Geneva, Switzerland., Finfer S; School of Public Health, Imperial College London, London, United Kingdom.; The George Institute for Global Health, University of New South Wales, Sydney, Australia., Fujii T; Jikei University School of Medicine, Jikei University Hospital, Tokyo, Japan., Giamarellos-Bourboulis EJ; Fourth Department of Internal Medicine and., Goligher EC; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada., Gong MN; Division of Critical Care Medicine and.; Division of Pulmonary Medicine, Department of Medicine and Department of Epidemiology and Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York., Karakike E; Second Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece., Liu VX; Division of Research, Kaiser Permanente, Oakland, California., Lumlertgul N; Excellence Center for Critical Care Nephrology, Division of Nephrology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Marshall JC; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada., Menon DK; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Meyer NJ; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Munroe ES; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan., Myatra SN; Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Ostermann M; King's College London, Guy's & St Thomas' Hospital, London, United Kingdom., Prescott HC; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.; Veterans Affairs Center for Clinical Management Research, Ann Arbor, Michigan., Randolph AG; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Anaesthesia and.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts., Schenck EJ; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York., Seymour CW; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Shankar-Hari M; Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom., Singer M; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom., Smit MR; Intensive Care., Tanaka A; Department of Intensive Care, University of Fukui Hospital, Yoshida, Fukui, Japan.; Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Taccone FS; Department des Soins Intensifs, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium; and., Thompson BT; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts., Torres LK; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York., van der Poll T; Center of Experimental and Molecular Medicine, and.; Division of Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Vincent JL; Department des Soins Intensifs, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium; and., Calfee CS; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Jul 15; Vol. 210 (2), pp. 155-166.

Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections

Autor: Thair, S.A. He, Y.D. Hasin-Brumshtein, Y. Sakaram, S. Pandya, R. Toh, J. Rawling, D. Remmel, M. Coyle, S. Dalekos, G.N. Koutsodimitropoulos, I. Vlachogianni, G. Gkeka, E. Karakike, E. Damoraki, G. Antonakos, N. Khatri, P. Giamarellos-Bourboulis, E.J. Sweeney, T.E.

The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::02aab4bb6351ae083f08b572e87f6017
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3056305

Differential response induced by LPS and MPLA in immunocompetent and septic individuals

Autor: Albert Vega, C. Karakike, E. Bartolo, F. Mouton, W. Cerrato, E. Brengel-Pesce, K. Giamarellos-Bourboulis, E.J. Mallet, F. Trouillet-Assant, S.

Lipopolysaccharide (LPS) and monophosphoryl lipid A (MPLA) induce, overall, similar transcriptional profiles in healthy individuals, although LPS has been shown to more potently induce pro-inflammatory cytokines. We explore herein whether MPLA could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::65694831079008290fd71025fae60c9e
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999888

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Autor: Kyriazopoulou, E. Huet, T. Cavalli, G. Gori, A. Kyprianou, M. Pickkers, P. Eugen-Olsen, J. Clerici, M. Veas, F. Chatellier, G. Kaplanski, G. Netea, M.G. Pontali, E. Gattorno, M. Cauchois, R. Kooistra, E. Kox, M. Bandera, A. Beaussier, H. Mangioni, D. Dagna, L. van der Meer, J.W.M. Giamarellos-Bourboulis, E.J. Hayem, G. Netea, M.G. van der Meer, J.W.M. Giamarellos-Bourboulis, E.J. Volpi, S. Sormani, M.P. Signori, A. Bozzi, G. Minoia, F. Aliberti, S. Grasselli, G. Alagna, L. Lombardi, A. Ungaro, R. Agostoni, C. Blasi, F. Costantino, G. Fracanzani, A.L. Montano, N. Peyvandi, F. Sottocorno, M. Muscatello, A. Filocamo, G. Papadopoulos, A. Mouktaroudi, M. Karakike, E. Saridaki, M. Gkavogianni, T. Katrini, K. Vechlidis, N. Avgoustou, C. Chalvatzis, S. Marantos, T. Damoulari, C. Damoraki, G. Ktena, S. Tsilika, M. Koufargyris, P. Karageorgos, A. Droggiti, D.-I. Koliakou, A. Poulakou, G. Tsiakos, K. Myrodia, D.-M. Gravvani, A. Trontzas, I.P. Syrigos, K. Kalomenidis, I. Kranidioti, E. Panagopoulos, P. Petrakis, V. Metallidis, S. Loli, G. Tsachouridou, O. Dalekos, G.N. Gatselis, N. Stefos, A. Georgiadou, S. Lygoura, V. Milionis, H. Kosmidou, M. Papanikolaou, I.C. Akinosoglou, K. Giannitsioti, E. Chrysos, G. Mavroudis, P. Sidiropoulou, C. Adamis, G. Fragkou, A. Rapti, A. Alexiou, Z. Symbardi, S. Masgala, A. Kostaki, K. Kostis, E. Samarkos, M. Bakakos, P. Tzavara, V. Dimakou, K. Tzatzagou, G. Chini, M. Kotsis, V. Tsoukalas, G. Bliziotis, I. Doumas, M. Argyraki, A. Kainis, I. Fantoni, M. Cingolani, A. Angheben, A. Cardellino, C.S. Castelli, F. Serino, F.S. Nicastri, E. Ippolito, G. Bassetti, M. Selmi, C. International Collaborative Group for Anakinra in COVID-19

Background: Anakinra might improve the prognosis of patients with moderate to severe COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). We aimed to assess the effect of anakinra treatment on mortality in pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a9acb0a5c15e9c11554aca5f19ae9e2c
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999762

REPLY.

Autor: Otero Sanchez L; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, C.U.B. Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium., Karakike E; Clinic of Infectious Diseases, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium., Moreno C; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, C.U.B. Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium., Trépo E; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, C.U.B. Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium., Gustot T; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, C.U.B. Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.; Inserm Unité 1149, Centre de recherche sur l'inflammation, Paris, France.; UMR S_1149, Université Paris Diderot, Paris, France.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2021 Nov; Vol. 74 (5), pp. 2927-2928. Date of Electronic Publication: 2021 Aug 31.