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Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

Autor: Jasmine Barra, Ramin Shiekhattar, Gabriel Gaidosh, Francis Impens, Kris Gevaert, Tobias K. Karakach, Eleonora Leucci, Jean-Christophe Marine, Mina Masoumeh Tayari, Felipe Beckedorff, Ezra Blumenthal, Nina Kirstein, Torben Heick Jensen

Publikováno v: Barra, J, Gaidos, G S, Blumenthal, E, Beckedorff, F, Tayar, M M, Kirstein, N, Karakac, T K, Jensen, T H, Impens, F, Gevaert, K, Leucci, E, Shiekhattar, R & Marine, J C 2020, ' Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1 ', Science Advances, vol. 6, no. 27, eaaz9072 . https://doi.org/10.1126/sciadv.aaz9072
Science Advances
SCIENCE ADVANCES

Integrator is a key regulator of NEAT1 isoform switching and, thereby, paraspeckles biogenesis and chemosensitivity.
RNA 3′ end processing provides a source of transcriptome diversification which affects various (patho)-physiological processes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e05843bcc9f8b219f81348e3fd51d0
https://lirias.kuleuven.be/handle/123456789/652180

Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model.

Autor: Parsons BD; University of Alberta, Department of Laboratory Medicine and Pathology, Edmonton, AB T6G 1C9, Canada., Medina-Luna D; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada., Scur M; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada., Pinelli M; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada., Gamage GS; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada., Chilvers RA; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada., Hamon Y; Aix Marseille University, CNRS, INSERM au Centre d'Immunologie de Marseille Luminy, 13288 Marseille, France., Ahmed IHI; Dalhousie University, Department of Pharmacology, Halifax, NS B3H 4R2, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada., Savary S; University of Bourgogne, Laboratoire Bio-PeroxIL EA7270, Dijon, France., Makrigiannis AP; Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada., Braverman NE; Research Institute of the McGill University Children's Hospital, Montreal, QC H4A 3J1, Canada., Rodriguez-Alcazar JF; University of Bonn, Institute of Innate Immunity, Medical Faculty, 53127 Bonn, Germany., Latz E; University of Bonn, Institute of Innate Immunity, Medical Faculty, 53127 Bonn, Germany., Karakach TK; Dalhousie University, Department of Pharmacology, Halifax, NS B3H 4R2, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada., Di Cara F; University of Alberta, Department of Laboratory Medicine and Pathology, Edmonton, AB T6G 1C9, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada. Electronic address: dicara@dal.ca.

Publikováno v: Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113744. Date of Electronic Publication: 2024 Feb 06.

Tumor vessel co-option probed by single-cell analysis.

Autor: Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium; Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp 2610, Belgium; Center for Oncological Research, University of Antwerp, Antwerp 2000, Belgium., De Rooij LPMH; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Cuypers A; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Rohlenova K; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Dumas SJ; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., García-Caballero M; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Meta E; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Amersfoort J; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Taverna F; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Becker LM; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Veiga N; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Cantelmo AR; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Conchinha NV; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Kalucka J; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Treps L; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Conradi LC; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Khan S; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Karakach TK; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Soenen S; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven 3000, Belgium., Vinckier S; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Schoonjans L; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510275, Guangzhou, Guangdong, P.R. China., Eelen G; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Van Laere S; Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp 2610, Belgium; Center for Oncological Research, University of Antwerp, Antwerp 2000, Belgium., Dewerchin M; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Dirix L; Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp 2610, Belgium; Center for Oncological Research, University of Antwerp, Antwerp 2000, Belgium., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis, CCB, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium., Luo Y; Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, P.R. China; BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, P.R. China. Electronic address: alun@biomed.au.dk., Vermeulen P; Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp 2610, Belgium; Center for Oncological Research, University of Antwerp, Antwerp 2000, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510275, Guangzhou, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark. Electronic address: peter.carmeliet@kuleuven.be.

Publikováno v: Cell reports [Cell Rep] 2021 Jun 15; Vol. 35 (11), pp. 109253.

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1 .

Autor: Barra J; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory for Molecular Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.; VIB Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium., Gaidosh GS; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Blumenthal E; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Beckedorff F; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Tayari MM; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Kirstein N; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Karakach TK; Bioinformatics Core Laboratory, Children's Hospital Research Institute of Manitoba (CHRIM), Winnipeg, Manitoba, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada., Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Impens F; VIB Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; VIB Proteomics Core, 9000 Ghent, Belgium., Gevaert K; VIB Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium., Leucci E; Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium., Shiekhattar R; Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA., Marine JC; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory for Molecular Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.

Publikováno v: Science advances [Sci Adv] 2020 Jul 03; Vol. 6 (27), pp. eaaz9072. Date of Electronic Publication: 2020 Jul 03 (Print Publication: 2020).