The Efficacy and Biopharmaceutical Properties of a Fixed-Dose Combination of Disulfiram and Benzyl Benzoate.

Autor: Lajarin-Reinares M; Department of Genetics and Microbiology, Campus Microbiology Unit, Autonomous Barcelona University, 08193 Barcelona, Spain.; Topical & Oral Development, Research and Development Reig Jofre Laboratories, 08970 Barcelona, Spain., Martinez-Esteve E; Topical & Oral Development, Research and Development Reig Jofre Laboratories, 08970 Barcelona, Spain., Pena-Rodríguez E; Topical & Oral Development, Research and Development Reig Jofre Laboratories, 08970 Barcelona, Spain., Cañellas-Santos M; Biotechnology Department, Research and Development, Reig Jofre Laboratories, 08970 Barcelona, Spain., Bulut S; Department of Development, Bioglan AB, 21124 Malmö, Sweden., Karabelas K; Department of Development, Bioglan AB, 21124 Malmö, Sweden., Clauss A; Department of Development, Bioglan AB, 21124 Malmö, Sweden., Nieto C; Topical & Oral Development, Research and Development Reig Jofre Laboratories, 08970 Barcelona, Spain., Mallandrich M; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain., Fernandez-Campos F; Topical & Oral Development, Research and Development Reig Jofre Laboratories, 08970 Barcelona, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 19; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 19.

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

Autor: Perry MWD; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Björhall K; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Bold P; DMPK, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Brűlls M; Early Product Development & Manufacturing, Pharmaceutical Sciences R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Börjesson U; Computational Chemistry, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Carlsson J; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Chang HA; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Chen Y; Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China., Eriksson A; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Fihn BM; DMPK, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Fransson R; Advanced Drug Delivery, Pharmaceutical Sciences R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Fredlund L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Ge H; Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China., Huang H; Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China., Karabelas K; Projects, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Lamm Bergström E; DMPK, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Lever S; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Lindmark H; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Mogemark M; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Nikitidis A; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Palmgren AP; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Pemberton N; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Petersen J; Structure & Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Rodrigo Blomqvist M; Bioscience Cough and In Vivo, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Smith RW; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Thomas MJ; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Ullah V; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Tyrchan C; Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Wennberg T; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Westin Eriksson A; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Yang W; Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China., Zhao S; Pharmaron Beijing Co., Ltd., No. 6 Taihe Road, BDA, Beijing 100176, P.R. China., Öster L; Structure & Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jun 24; Vol. 64 (12), pp. 8053-8075. Date of Electronic Publication: 2021 Jun 03.

Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.

Autor: Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J; Medicinal Chemistry Department, Cardiovascular and Metabolic Diseases IMED Biotech Unit , AstraZeneca Gothenburg , 43183 Mölndal , Sweden., Larsson J, Sivars U, Hultin L; Precision Medicine Laboratories, Precision Medicine and Genomics IMED Biotech Unit , AstraZeneca Gothenburg , 43183 Mölndal , Sweden., Andersson U; Drug Safety and Metabolism IMED Biotech Unit , AstraZeneca Gothenburg , 43183 Mölndal , Sweden., Sanganee HJ; Scientific Partnering & Alliances IMED Biotech Unit , AstraZeneca , SK10 4TF Cambridge , United Kingdom., Stenvall K, Leidvik B; Discovery Sciences IMED Biotech Unit , AstraZeneca Gothenburg , 43183 Mölndal , Sweden., Gedda K; Discovery Sciences IMED Biotech Unit , AstraZeneca Gothenburg , 43183 Mölndal , Sweden., Jinton L, Rydén Landergren M, Karabelas K

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jul 26; Vol. 61 (14), pp. 5974-5987. Date of Electronic Publication: 2018 Jul 06.

Impact of Time on Parameters for Assessing the Microstructure Equivalence of Topical Products: Diclofenac 1% Emulsion as a Case Study.

Autor: Mañez-Asensi, Andreu^1,2 (AUTHOR) andreu.manez@uv.es, Hernández, Mª Jesús³ (AUTHOR) m.jesus.hernandez@uv.es, Mangas-Sanjuán, Víctor^1,2 (AUTHOR) victor.mangas@uv.es, Salvador, Ana⁴ (AUTHOR) asalvador@iata.csic.es, Merino-Sanjuán, Matilde^1,2 (AUTHOR) matilde.merino@uv.es, Merino, Virginia^1,2 (AUTHOR)

Publikováno v: Pharmaceutics. Jun2024, Vol. 16 Issue 6, p749. 14p.

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease.

Autor: Mårdh CK; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Root J; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Uddin M; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Stenvall K; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Malmgren A; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Karabelas K; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden., Thomas M; Respiratory, Inflammation and Autoimmunity IMED, AstraZeneca R&D, Gothenburg, Sweden.

Publikováno v: Journal of immunology research [J Immunol Res] 2017; Vol. 2017, pp. 5273201. Date of Electronic Publication: 2017 May 15.