Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kara M. Soroko"'
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usua
Externí odkaz:
https://doaj.org/article/48d1999c6108493896009222e6cd2895
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its two bromodomains, and NUT recruits the p300 histone acetyltransfers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443954089c12bc613ff9662283e9aeac
https://doi.org/10.1158/1535-7163.c.6542821.v1
https://doi.org/10.1158/1535-7163.c.6542821.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental Table S1. Statistical analysis of survival in PER-403 model, full study. Supplemental Table S2. Statistical analysis of survival in 10-15 mouse model, full study. Supplemental Table S3. Statistical analysis of survival in 14169 model, fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ce5c6c0f1f31ef00393d18c6eef31b
https://doi.org/10.1158/1535-7163.22520881.v1
https://doi.org/10.1158/1535-7163.22520881.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental Figure S1: NEO2734 induces differentiation in 10-15 cells. Supplemental Figure S2: Caspase-mediated apoptosis plays a minimal role in the activity of GNE-781, OTX015, or NEO2734. Supplemental Figure S3: BRD4-NUT protein levels decrease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a1f4894b3d5165744e623dd4428b44
https://doi.org/10.1158/1535-7163.22520908.v1
https://doi.org/10.1158/1535-7163.22520908.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6ffe4170e4aef0664906df6b39bbf0
https://doi.org/10.1158/1535-7163.22520902
https://doi.org/10.1158/1535-7163.22520902
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe62cc2bffe5c35fe4144d12b0bef5
https://doi.org/10.1158/1535-7163.22520890.v1
https://doi.org/10.1158/1535-7163.22520890.v1
Autor:
David A. Reardon, Gordon J. Freeman, Arlene H. Sharpe, Paul T. Kirschmeier, Ana C. Anderson, E. Antonio Chiocca, Peter K. Sorger, Keith L. Ligon, Gareth R. L. Grant, Quang-Dé Nguyen, Dennis M. Bonal, Gregory J. Baker, Mary Jane Lim-Fat, Yan Gao, Aine Knott, Chhayheng Chhoeu, Kara M. Soroko, Margaret K. Wilkens, Michael J. Poitras, Benjamin K. Eschle, Maria C. Speranza, Prafulla C. Gokhale, J. Bryan Iorgulescu
Purpose:Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data exist describing how dexamethasone affects the immune system systemically and intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e886220389a10bda3ab03ada9be3e
https://doi.org/10.1158/1078-0432.c.6530154.v1
https://doi.org/10.1158/1078-0432.c.6530154.v1
Autor:
David A. Reardon, Gordon J. Freeman, Arlene H. Sharpe, Paul T. Kirschmeier, Ana C. Anderson, E. Antonio Chiocca, Peter K. Sorger, Keith L. Ligon, Gareth R. L. Grant, Quang-Dé Nguyen, Dennis M. Bonal, Gregory J. Baker, Mary Jane Lim-Fat, Yan Gao, Aine Knott, Chhayheng Chhoeu, Kara M. Soroko, Margaret K. Wilkens, Michael J. Poitras, Benjamin K. Eschle, Maria C. Speranza, Prafulla C. Gokhale, J. Bryan Iorgulescu
Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0716037c9ea39baa7b2bb3924a434c
https://doi.org/10.1158/1078-0432.22479231.v1
https://doi.org/10.1158/1078-0432.22479231.v1
Autor:
David A. Reardon, Gordon J. Freeman, Arlene H. Sharpe, Paul T. Kirschmeier, Ana C. Anderson, E. Antonio Chiocca, Peter K. Sorger, Keith L. Ligon, Gareth R. L. Grant, Quang-Dé Nguyen, Dennis M. Bonal, Gregory J. Baker, Mary Jane Lim-Fat, Yan Gao, Aine Knott, Chhayheng Chhoeu, Kara M. Soroko, Margaret K. Wilkens, Michael J. Poitras, Benjamin K. Eschle, Maria C. Speranza, Prafulla C. Gokhale, J. Bryan Iorgulescu
Supplementary Methods and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a869aad70edd863de830b1bd54456
https://doi.org/10.1158/1078-0432.22479219
https://doi.org/10.1158/1078-0432.22479219