Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kara L. Queeney"'
Autor:
Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach
Publikováno v:
Journal of Medicinal Chemistry. 61:11074-11100
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba127f0c7da3013553a7215d8180f4bd
https://doi.org/10.1021/acs.jmedchem.8b01098
https://doi.org/10.1021/acs.jmedchem.8b01098
Autor:
Kara L. Queeney, Maria A. Argiriadi, Anil Vasudevan, Jürgen Dinges, Eric Dominguez, Kelly E. Desino, Christopher M. Harris, Grier A. Wallace, Tegest Kebede, Hetal Patel, Denise C. Perron
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2297-2302
Inhibition of sphingosine-1-phosphate lyase has recently been proposed as a potential treatment option for inflammatory disorders such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. In this report we describe our hit-to-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64c0c172559d9745d93a9a6ac19ad24
https://doi.org/10.1016/j.bmcl.2016.03.043
https://doi.org/10.1016/j.bmcl.2016.03.043
Autor:
Grier A. Wallace, Elzbieta Radziejewska, Susan C. Marchie, Jürgen Dinges, Kara L. Queeney, Charles W. Hutchins, David Banach, Christopher M. Harris, Eric Dominguez, Russell A. Judge, Maria A. Argiriadi, Jennifer DiMauro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2293-2296
S1P Lyase (SPL) has been described as a drug target in the treatment of autoimmune diseases. It plays an important role in maintaining intracellular levels of S1P thereby affecting T cell egress from lymphoid tissues. Several groups have already publ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6853bcc358b9233f783ad0a44949c7
https://doi.org/10.1016/j.bmcl.2016.02.084
https://doi.org/10.1016/j.bmcl.2016.02.084