Výsledky vyhledávání - "Kara J, Filbey"

Akademický článek

The Gastrointestinal Helminth Heligmosomoides bakeri Suppresses Inflammation in a Model of Contact Hypersensitivity

Autor: Kara J. Filbey, Palak H. Mehta, Kimberley J. Meijlink, Christophe Pellefigues, Alfonso J. Schmidt, Graham Le Gros

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Helminths regulate host immune responses to ensure their own long-term survival. Numerous studies have demonstrated that these helminth-induced regulatory mechanisms can also limit host inflammatory responses in several disease models. We used the He

Externí odkaz: https://doaj.org/article/b65568ea2c09443eb87a1ac156163551

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Akademický článek

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signa

Externí odkaz: https://doaj.org/article/8966a9c3f97c4921a792b74844b1800f

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Akademický článek

Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite

Autor: Kara J. Filbey, Fumi Varyani, Yvonne Harcus, James P. Hewitson, Danielle J. Smyth, Henry J. McSorley, Alasdair Ivens, Susanne Nylén, Martin Rottenberg, Stephan Löser, Rick M. Maizels

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway. We have found that macrophage migration inhibitory factor (MIF) is essential for t

Externí odkaz: https://doaj.org/article/4ef2bdd6330249d7a3a47b2de062d4dc

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The Basoph8 mice enable an unbiased detection and a conditional depletion of basophils

Autor: Palak Mehta, Jodie Chandler, Christophe Pellefigues, Karmella Naidoo, Mali Camberis, Bibek Yumnam, Melanie Prout, Graham Le Gros, Sally Chappell, Kara J. Filbey

Publikováno v: Pellefigues, C, Mehta, P, Naidoo, K, Yumnam, B, Chandler, J, Chappell, S, Filbey, K, Camberis, M & Le Gros, G 2019, ' The Basoph8 mice enable an unbiased detection and a conditional depletion of basophils. ', Frontiers in Immunology, vol. 10 . https://doi.org/10.3389/fimmu.2019.02143
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)

Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5648bf1ee84303306e7f39249102ce
https://ora.ox.ac.uk/objects/uuid:fdc1f43e-65b0-464e-b58b-6e55ae876979

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Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation

Autor: Rossana Azzoni, Kara J. Filbey, Rufus H. Daw, Maria Z. Krauss, Matthew R. Hepworth, Joanne E. Konkel, Edith M. Hessel, Yashaswini Kannan, John R. Grainger

Eosinophils are key contributors to allergic pathology, however, increasingly eosinophils are described to have important roles in organ health and immunoregulation. Factors that impact these diverse functions of eosinophils are not understood. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2641fd496a9a1fcc8c98105a35d23ae6
https://doi.org/10.1101/2022.08.04.502285

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Akademický článek

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Autor: James P Hewitson, Kara J Filbey, Julia Esser-von Bieren, Mali Camberis, Christian Schwartz, Janice Murray, Lisa A Reynolds, Natalie Blair, Elaine Robertson, Yvonne Harcus, Louis Boon, Stanley Ching-Cheng Huang, Lihua Yang, Yizheng Tu, Mark J Miller, David Voehringer, Graham Le Gros, Nicola Harris, Rick M Maizels

Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004676 (2015)

Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse

Externí odkaz: https://doaj.org/article/54914d01b559441e841ee0d05556fec2

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Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites

Autor: Kara J. Filbey, Anthony J. Kettle, Rufus Turner, Ramon M. Eichenberger, Paul R. Giacomin, Jodie Chandler, Graham Le Gros, Mali Camberis

Publikováno v: Filbey, K, Camberis, M, Chandler, J, Turner, R, Kettle, A, Eichenberger, R, Giacomin, P & Le Gros, G 2018, ' Intestinal helminth infection promotes IL-5-and CD4+ T cell-dependent immunity in the lung against migrating parasites. ', Mucosal Immunology . https://doi.org/10.1038/s41385-018-0102-8

The ability of helminths to manipulate the immune system of their hosts to ensure their own survival is often credited with affecting responses to other pathogens. We undertook co-infection experiments in mice to determine how infection with the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f554e3ad95a3fb2e1b16d12e3ba000fc
https://doi.org/10.1038/s41385-018-0102-8

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Integrated miRNA/Cytokine/Chemokine Profiling Reveals Severity-Associated Step Changes and Principal Correlates of Fatality in COVID-19

Publikováno v: SSRN Electronic Journal.

Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalised COVID-19 patients (Cohort 1) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d143f6958c33c8761f5f3b9994a6de9
https://doi.org/10.2139/ssrn.3940630

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Akademický článek

Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

Autor: James P Hewitson, Al C Ivens, Yvonne Harcus, Kara J Filbey, Henry J McSorley, Janice Murray, Stephen Bridgett, David Ashford, Adam A Dowle, Rick M Maizels

Publikováno v: PLoS Pathogens, Vol 9, Iss 8, p e1003492 (2013)

Gastrointestinal nematode parasites infect over 1 billion humans, with little evidence for generation of sterilising immunity. These helminths are highly adapted to their mammalian host, following a developmental program through successive niches, wh

Externí odkaz: https://doaj.org/article/e90175e6e0a34370b2d69d1430927d27

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