Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kara Foshay"'
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Meningiomas are relatively common, and typically benign intracranial tumors, which in many cases can be cured by surgical resection. However, less prevalent, high grade meningiomas, grow quickly, and recur frequently despite treatment, leading to poo
Externí odkaz:
https://doaj.org/article/b354bd8e39494c2aac01e7b5d9d199f7
Publikováno v:
Stem Cells International, Vol 2010 (2010)
Understanding signal transduction mechanisms that drive differentiation of adult or embryonic stem cells (ESCs) is imperative if they are to be used to cure disease. While the list of signaling pathways regulating stem cell differentiation is growing
Externí odkaz:
https://doaj.org/article/e8aebda7b979412b81b98d6661a57960
Capacity to erase gene occlusion is a defining feature distinguishing naive from primed pluripotency
Autor:
Bruce T. Lahn, Kara Foshay, Wu B, Andy Peng Xiang, Guoping Fan, Timothy J. Looney, Jedidiah Gaetz, Fernandes Cj, Samuel W. Baker, Jung-Hyun Lee, Liqing Zhang
SUMMARYPluripotent stem cells can exist in either the naive state representing a developmental blank slate or the downstream primed state poised for differentiation. Currently, known differences between these two states are mostly phenomenological, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bc34699131e81132df1d38b7dcf8e2
https://doi.org/10.1101/2021.05.04.442547
https://doi.org/10.1101/2021.05.04.442547
Autor:
Laura M. Prolo, Gordon Li, Allen Waziri, Amy Li, Emily Luo, Christy Wilson, Michael C. Bassik, Gerald A. Grant, Ryan T. Nitta, Jonathon J. Parker, David W. Morgens, Gigi Nwagbo, Scott F. Owen, Johana C. M. Vega L, Sara Bolin, Richard J. Reimer, Kara Foshay
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Among high-grade brain tumors, glioblastoma is particularly difficult to treat, in part due to its highly infiltrative nature which contributes to the malignant phenotype and high mortality in patients. In order to better understand the signaling pat
Autor:
Bette K. Kleinschmidt-DeMasters, Kara Foshay, Lee Niswander, Jonathon J. Parker, Allen Waziri, Peter Canoll
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Intratumoral genetic heterogeneity is a widely accepted characteristic of human cancer, including the most common primary malignant brain tumor, glioblastoma. However, the variability in biological behaviors amongst cells within individual tumors is
Publikováno v:
NPJ Precision Oncology
npj Precision Oncology, Vol 2, Iss 1, Pp 1-8 (2018)
npj Precision Oncology, Vol 2, Iss 1, Pp 1-8 (2018)
The prognosis of glioblastoma has changed little over the past two decades, with only minor improvements in length of overall survival through the addition of temozolomide (temodal) to standard of care and the recommended use of alternating electric
Glioblastoma (GBM) continues to carry an extremely poor clinical prognosis despite surgical, chemotherapeutic, and radiation therapy. Progressive tumor invasion into surrounding brain parenchyma represents an enduring therapeutic challenge. To develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a1d07e273fea56a73a626f9c44e462
https://europepmc.org/articles/PMC5612552/
https://europepmc.org/articles/PMC5612552/
Autor:
Lauren Gardiner, Masood Sadaat, Allen Waziri, Shiva Krishnan, Jonathan Parker, Kara Foshay, Vashali Jain
Publikováno v:
Neuro-Oncology. 19:vi259-vi259
Molecular heterogeneity in glioblastoma (GBM) is widely recognized at the inter-patient and intra-tumoral levels. More recently, we provided confirmation that endogenous heterogeneity also exists on a biological basis through analysis of migrating ce
Autor:
Masood Sadaat, Jonathan Parker, Kara Foshay, Lauren Gardiner, Shiva Krishnan, Vashali Jain, Allen Waziri
Publikováno v:
Neuro-Oncology. 19:vi254-vi254
Invasion of tumor cells through the brain remains a significant challenge for treating glioblastoma (GBM). In an effort to better target this phenomenon, we developed a technique for organotypic slice culture of human GBM, which when used in combinat
Publikováno v:
Cancer Biomarkers. 3:233-244
The identification of distinct prostate cancer stem cell biomarkers is necessary as researchers attempt to isolate, characterize, and therapeutically target these tumor initiating cells. However, in reading the current literature it is frequently dif